52 completed, 19 unknown, 12 recruiting, 5 not yet recruiting. 25 Not applicable, 14 Phase 3, 9 Phase 2, 6 Phase 1, 4 Early Phase 1.
Follow Familial Hypercholesterolemia: new trials by email Literature Review of Familial Hypercholesterolemia trials Research Report on Familial Hypercholesterolemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Penn Family Screening for Familial Hypercholesterolemia (NHLBI R33) Trial 3 Cascade Screening - Familial Hypercholesterolemia | Not applicable | Not yet recruiting | Northwestern University | 110 | 2026-11-15 | 2026-11-05 |
| Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP Cascade testing, Standard of Care - Familial Hypercholesterolemia | Not applicable | Not yet recruiting | Mayo Clinic | 480 | 2026-10-20 | 2026-09-18 |
| The ORIGIN-FH Study Screening for FH - Heterozygous Familial Hypercholesterolemia (HeFH), Homozygous Familial Hypercholesterolemia (HoFH) | Not applicable | Recruiting | University of Wisconsin, Madison | 70 | 2026-02-14 | 2026-10-13 |
| National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry whole genome sequencing - Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated | Recruiting | Hospital do Coracao | 1211 | 2025-04-30 | 2026-05-08 | |
| Child-Parent Familial Hypercholesterolemia Screening no interventions - Familial Hypercholesterolemia | Recruiting | Children's Hospital of Fudan University | 15000 | 2025-04-01 | 2026-05-15 | |
| An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH) Placebo phytosterol, Placebo krill oil, Phytosterol - Familial Hypercholesterolemia | Not applicable | Active not recruiting | Hospital do Coracao | 300 | 2024-10-23 | 2026-05-12 |
| Atlantic Lipid Lowering Treatment Optimization Program Supportive care - Familial Hypercholesterolemia, Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia | Not applicable | Recruiting | Atlantic Health System | 250 | 2024-07-01 | 2025-08-03 |
| Safety and Efficacy Study of NGGT006 in Refractory Hypercholesterolemia Patients NGGT006 - Refractory Hypercholesterolemia, Familial Hypercholesterolemia | Early Phase 1 | Not yet recruiting | Suzhou Municipal Hospital | 9 | 2024-06-01 | 2024-04-17 |
| Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH) YOLT-101 - Familial Hypercholesterolemia | Early Phase 1 | Recruiting | RenJi Hospital | 20 | 2024-05-24 | 2025-04-30 |
| Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH) YOLT-101 - Familial Hypercholesterolemia | Early Phase 1 | Unknown | The First Affiliated Hospital of Bengbu Medical University | 13 | 2024-04-01 | 2024-06-17 |
| Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia. Healthy diet - Familial Hypercholesterolemia, Nutrition, Healthy | Not applicable | Completed | Laval University | 11 | 2024-04-01 | 2024-10-21 |
| Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies Combination Therapy, Monotherapy obicetrapib, Monotherapy ezetimibe - Dyslipidemias, Hypercholesterolemia | Phase 3 | Completed | NewAmsterdam Pharma | 407 | 2024-03-01 | 2025-10-08 |
| 2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH) 2-Hydroxybenzylamine, Placebo - Familial Hypercholesterolemia | Phase 2 | Recruiting | Vanderbilt University Medical Center | 72 | 2024-02-14 | 2026-08-07 |
| Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection. Biochemistry interpretive comment on elevated LDL-C levels - Familial Hypercholesterolemia | Not applicable | Recruiting | Odense University Hospital | 2000 | 2023-12-01 | 2026-02-20 |
| The Danish Familial Hypercholesterolemia Organized Coronary Screening Trial Visualization of coronary Imaging and oral description - Familial Hypercholesterolemia, Atherosclerosis | Not applicable | Completed | Odense University Hospital | 116 | 2023-09-01 | 2026-10-16 |
| A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids Enlicitide Decanoate, Placebo - Hypercholesterolemia, Familial Hypercholesterolemia | Phase 3 | Completed | Merck Sharp & Dohme LLC | 2912 | 2023-08-10 | 2026-09-24 |
| A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH) Enlicitide Decanoate, Placebo - Hypercholesterolemia, Familial Hypercholesterolemia | Phase 3 | Completed | Merck Sharp & Dohme LLC | 303 | 2023-08-08 | 2026-02-24 |
| A VSA003 Phase 1 Study in Chinese Adult Healthy Volunteers VSA003, 0.9% NaCl - Dyslipidemias, Familial Hypercholesterolemia | Phase 1 | Completed | Visirna Therapeutics HK Limited | 36 | 2023-06-01 | 2025-09-12 |
| Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia phytosterol, krill oil, Placebo phytosterol - Familial Hypercholesterolemia | Not applicable | Completed | Hospital do Coracao | 58 | 2023-05-22 | 2025-12-30 |
| Comparing Direct vs Indirect Methods for Cascade Screening Direct contact of family members for cascade screening of relevant variants - Long QT Syndrome, Familial Hypercholesterolemia | Not applicable | Recruiting | University of Maryland, Baltimore | 200 | 2023-05-15 | 2026-04-14 |
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Hyperlipoproteinemia Type II (102) · Hypercholesterolemia (23) · Atherosclerosis (9) · Cardiovascular Diseases (7) · Dyslipidemias (6) · Homozygous Familial Hypercholesterolemia (5) · Genetic Diseases, Inborn (4) · Hypertriglyceridemia (3) · Acute Coronary Syndrome (2) · Coronary Artery Disease (2) · Hyperlipidemias (2) · Hyperlipoproteinemia Type III (2) · Lipid Metabolism Disorders (2) · Long QT Syndrome (2) · Medication Adherence (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (102) · Nutritional and Metabolic Diseases (102) · Hyperlipoproteinemias (101) · Lipid Metabolism, Inborn Errors (101) · Metabolism, Inborn Errors (101) · Hyperlipidemias (100) · Lipid Metabolism Disorders (100) · Metabolic Diseases (100) · Genetic Diseases, Inborn (98) · Dyslipidemias (96) · Vascular Diseases (17) · Cardiovascular Diseases (16) · Arterial Occlusive Diseases (12) · Arteriosclerosis (11) · Heart Diseases (8)
Ezetimibe (5) · Genetic Testing (3) · MK-0616 (3) · evolocumab (3) · ALN-PCS (2) · Atorvastatin (2) · Motivational Interviewing (2) · Phytosterols (2) · Rapeseed Oil (2) · Rosuvastatin Calcium (2) · Saline Solution (2) · implitapide (2) · 2-(aminomethyl)phenol (1) · BMS201038 (1) · Blood Component Removal (1)
Laval University (4) · Organon and Co (4) · Hospital do Coracao (3) · Merck Sharp & Dohme LLC (3) · NewAmsterdam Pharma (3) · Northwestern University (3) · Novartis Pharmaceuticals (3) · Amgen (2) · Geisinger Clinic (2) · Isfahan University of Medical Sciences (2) · Mayo Clinic (2) · Medical Research Laboratories International (2) · Medical University of Vienna (2) · Odense University Hospital (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2)
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Aline Marcadenti, PhD (2) · Erlon O Abreu-Silva, MSc (2) · Marc Ditmarsch (2) · Adam H Buchanan, MS, MPH, CGC (1) · Adriana B Carvalho, PhD (1) · Alberico L Catapano, PhD (1) · Alexandra Ershova, MD, PhD (1) · Alexandre B Cavalcanti, PhD (1) · Alexey Meshkov, MD, PhD (1) · Amy Peterson, MD, MS (1) · Angela C Bersch-Ferreira, PhD (1)
PMID 34617591, PMID 12034651, PMID 20223367, PMID 26330422, PMID 27050191, PMID 27678432, PMID 28306389, PMID 28538111, PMID 28619117, PMID 28965615, PMID 29080546, PMID 29407879, PMID 29602595, PMID 29735484, PMID 30312929, PMID 30487231, PMID 31553410, PMID 31630870, PMID 32005605, PMID 32414353, PMID 32744105, PMID 33900278, PMID 33990512, PMID 34521694, PMID 34635577, PMID 36173399, PMID 36520008, PMID 36600332, PMID 36620965, PMID 36889610, PMID 36999528, PMID 37009731, PMID 37607748, PMID 37626170, PMID 37801454, PMID 38063346, PMID 38101429, PMID 38205656, PMID 38228467, PMID 38594685, PMID 38705341, PMID 39470058, PMID 39531353, PMID 39728301, PMID 40288796, PMID 40337982, PMID 40347969, PMID 40587053, PMID 40810443, PMID 41109840
2015 (2), 2008 (1), 2016 (1), P01HL116263 (1), R01HG009671 (1), R61HL161775 (1), U01HG006379 (1)