116 completed, 28 unknown, 18 terminated, 8 withdrawn. 108 Phase 2, 46 Phase 3, 19 Phase 1, 4 Not applicable, 2 Phase 4.
Follow Interferon-alpha: new trials by email Literature Review of Interferon-alpha trials Research Report on Interferon-alpha
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Real-World Study of Antiviral Therapy in Children With Chronic Hepatitis B Nucleos(t)ide Analogues, Interferon alfa, NAs combined with IFNα - HBV, Chronic Hepatitis b | Not yet recruiting | Beijing 302 Hospital | 2000 | 2025-05-01 | 2025-04-29 | |
| Interferon Alfa Therapy Based on Th17 Profile in Membranous Nephropathy Peginterferon Alfa-2A 180 MCG/ML Injectable Solution - Membranous Nephropathy | Phase 2 | Terminated | Centre Hospitalier Universitaire de Nice | 4 | 2023-09-14 | 2026-06-18 |
| COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial; Interferon alfa, Selinexor, Lenzilumab - Cancer, Covid19 | Phase 3 | Completed | Peter MacCallum Cancer Centre, Australia | 441 | 2020-12-17 | 2023-08-24 |
| Efficacy and Safety of High-dose Vitamin C Combined With Chinese Medicine Against Coronavirus Pneumonia (COVID-19) Alpha-interferon alpha, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste, fumigation/inhalation of vitamin C, Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and 5% glucose, Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and high-dose vitamin C treatment - COVID-19 | Not applicable | Completed | Xi'an International Medical Center Hospital | 30 | 2020-02-06 | 2023-09-21 |
| MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera Ruxolitinib, Hydroxycarbamide, Interferon-Alpha - Polycythemia Vera | Phase 3 | Recruiting | University of Birmingham | 586 | 2019-10-25 | 2026-10-26 |
| Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP) Microdebrider, Cold-steel surgery (forceps), Carbon dioxide laser - Recurrent Respiratory Papillomatosis, Human Papilloma Virus | Unknown | Newcastle-upon-Tyne Hospitals NHS Trust | 400 | 2018-04-01 | 2022-01-11 | |
| Interferon-α Prevents Leukemia Relapse of AML Patients After Transplantation Interferon-alpha - Interferon-A-2B, Relapse | Not applicable | Withdrawn | Peking University People's Hospital | 2017-05-01 | 2020-09-23 | |
| Pharmaco-immunological Study of Interferon-alpha and Metronomic Cyclophosphamide Association in Neuroendocrine Tumors Metronomic cyclophosphamide, Interferon-alpha - Neuroendocrine Tumors | Phase 2 | Completed | Centre Hospitalier Universitaire de Besancon | 28 | 2015-05-19 | 2021-08-02 |
| Adjuvant Therapy of Skin Melanoma With Alpha Interferon and Naderin Surgical resection, Adjuvant Radiotherapy, interferon alfa - Melanoma Stage I, Melanoma Stage III | Phase 2 | Completed | MIPO Clinic | 278 | 2014-01-01 | 2026-06-30 |
| Interferon for the Intervention of Molecular Relapse in t (8; 21) AML After Allo-HSCT Interferon-alpha - Acute Myeloid Leukemia | Phase 4 | Unknown | Peking University People's Hospital | 40 | 2013-10-01 | 2016-09-29 |
| P2 Study of Postoperative Interferon/Fluorouracil vs Cisplatin/Fluorouracil for Hepatocellular Carcinoma. Interferon Alfa、Fluorouracil, Cisplatin、Fluorouracil - Hepatocellular Carcinoma | Phase 2 | Unknown | Kansai Hepatobiliary Oncology Group | 66 | 2013-03-01 | 2018-05-18 |
| Pegylated Interferon Alpha-2b in Early Primary Myelofibrosis Peginterferon alfa-2a - Myelofibrosis | Phase 2 | Terminated | Weill Medical College of Cornell University | 8 | 2013-01-01 | 2018-07-24 |
| Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer Chemokin Modulatory Regimen (5 MU/m2), Chemokin Modulatory Regimen (10 MU/m2), Chemokin Modulatory Regimen (20 MU/m2) - Colorectal Cancer, Colorectal Carcinoma | Phase 1 / Phase 2 | Terminated | Roswell Park Cancer Institute | 15 | 2012-10-01 | 2023-10-27 |
| Adjuvant IFN-α for Patients Underwent Curative Surgery for HCC With a Low miR-26 Expression interferon-alpha (IFN-alpha) - Hepatocellular Carcinoma | Phase 3 | Unknown | Fudan University | 296 | 2012-08-01 | 2018-06-01 |
| Inflammation, Stress & Social Behavior: Using Ecological Assessments & Model Systems to Enhance Relevance to Health Outcomes Interferon-alpha - Hepatitis C | Not applicable | Withdrawn | University of Arizona | 2012-06-01 | 2013-07-22 | |
| Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) Nilotinib, interferon-alfa - Chronic Myeloid Leukemia | Phase 1 | Completed | Novartis Pharmaceuticals | 4 | 2012-04-01 | 2015-05-05 |
| Interferon Alpha Lozenges Plus Oseltamivir for Influenza Treatment Interferon-alpha, Oseltamivir, maltose - Influenza A Virus Infection | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 40 | 2011-01-01 | 2013-08-21 |
| Hyperthermia and Mitomycin C, Bacillus Calmette-Guerin, or Standard Therapy as Second-Line Therapy in Treating Patients With Recurrent Bladder Cancer BCG solution, recombinant interferon alfa, epirubicin hydrochloride - Bladder Cancer | Phase 3 | Unknown | Cancer Research Campaign Clinical Trials Centre | 242 | 2009-10-01 | 2013-08-12 |
| Interferon-alpha Lozenges for Prevention of Relapse in Hepatitis C interferon-alpha lozenges, placebo lozenges - Hepatitis C, Chronic | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 169 | 2009-06-01 | 2024-02-21 |
| Interferon Alpha Lozenges in the Prevention of Winter Colds and Flu interferon-alpha, placebo - Upper Respiratory Tract Infections | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 200 | 2009-04-01 | 2011-09-16 |
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Carcinoma, Renal Cell (32) · Leukemia (26) · Melanoma (26) · Kidney Neoplasms (25) · Leukemia, Myeloid, Chronic-Phase (22) · Lymphoma (17) · Multiple Myeloma (17) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (16) · Neoplasms, Plasma Cell (13) · Lymphoma, Follicular (12) · Pancreatic Neoplasms (9) · Leukemia, Lymphocytic, Chronic, B-Cell (8) · Lymphoma, Mantle-Cell (8) · Burkitt Lymphoma (7) · Leukemia, Myeloid, Acute (7)
National Cancer Institute (NCI) (12) · Eastern Cooperative Oncology Group (9) · M.D. Anderson Cancer Center (9) · Hoag Memorial Hospital Presbyterian (6) · SWOG Cancer Research Network (6) · Ainos, Inc. (f/k/a Amarillo Biosciences Inc. (5) · European Organisation for Research and Treatment of Cancer - EORTC (5) · The University of Texas Health Science Center, Houston (5) · Fred Hutchinson Cancer Center (4) · Masonic Cancer Center, University of Minnesota (4) · Memorial Sloan Kettering Cancer Center (4) · Kidney Cancer Research Bureau (3) · Medical Research Council (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Weill Medical College of Cornell University (3)
United States (121) · United Kingdom (19) · Germany (13) · Italy (12) · France (10) · Netherlands (10) · Australia (9) · Belgium (8) · Russia (8) · Switzerland (8) · Canada (7) · Poland (6) · Spain (6) · China (5) · Turkey (Türkiye) (5)
Robert O. Dillman, MD, FACP (6) · Charles L. Wiseman, MD, FACP (3) · John M. Kirkwood, MD (3) · Lawrence E. Flaherty, MD (3) · Ruediger Hehlmann, MD (3) · Alberto S. Pappo, MD (2) · B. Douglas Smith, MD (2) · Catherine M. Verfaillie, MD (2) · Ilya V. Tsimafeyeu, MD (2) · Jane N. Winter, MD (2) · Joan M Bull, M.D. (2) · Joan M.C. Bull, MD (2) · John P. Hanson, MD (2) · Laura F. Hutchins, MD (2) · Leo I. Gordon, MD (2)
PMID 37146227, PMID 25577718, PMID 27238653, PMID 28273028, PMID 28410911, PMID 12074329, PMID 12637609, PMID 14508361, PMID 14581348, PMID 14665609, PMID 15010373, PMID 15102658, PMID 15308571, PMID 15961764, PMID 16170182, PMID 16198768, PMID 16249352, PMID 16260693, PMID 16432076, PMID 16706633, PMID 17023156, PMID 17151364, PMID 17215529, PMID 17366595, PMID 17443000, PMID 17538086, PMID 17932881, PMID 18077791, PMID 18162124, PMID 18166796, PMID 18256322, PMID 18608594, PMID 18645482, PMID 18650621, PMID 18794104, PMID 18936475, PMID 19001327, PMID 19117345, PMID 19204798, PMID 19228745, PMID 19430405, PMID 19622576, PMID 19648168, PMID 19717547, PMID 19880501, PMID 19965667, PMID 20032498, PMID 20104222, PMID 20142590, PMID 20153039
P30CA016672 (7), U10CA032102 (5), P30CA006973 (3), P30CA033572 (2), U10CA031946 (2), M01RR002558 (1), N01CM17101 (1), N01CM62207 (1), P01CA075606 (1), P30CA006927 (1), P30CA013330 (1), P30CA016058 (1), P30CA023108 (1), P50CA091846 (1), R01AT007297 (1)