31 suspended. 31 Phase 1, 13 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 31 | Suspended 31 |
| Phase 2 | 13 | Suspended 13 |
Follow Digestive System Neoplasms: new trials by email Literature Review of Digestive System Neoplasms trials Research Report on Digestive System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma Anti-GPC3-CAR Autologous T Lymphocytes, Biospecimen Collection, Computed Tomography - Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma | Phase 1 | Suspended | Roswell Park Cancer Institute | 24 | 2026-11-15 | 2026-09-15 |
| TROP2 CAREngineered Cord Blood-Derived NK Cells + Belzutifan In Pancreatic Cancer TGFBR2 KO CAR27/IL-15 NK cells - Pancreatic Cancer | Phase 1 / Phase 2 | Suspended | M.D. Anderson Cancer Center | 37 | 2026-05-26 | 2026-11-03 |
| Stereotactic Centralized Ablative Radiotherapy for Locally Advanced Pancreatic Cancer: A Single-Arm Phase I Safety and Feasibility Study SCART Dose Escalation Arm - Pancreatic Cancer, Locally Advanced Pancreatic Cancer | Phase 1 | Suspended | Shandong Cancer Hospital and Institute | 24 | 2025-09-10 | 2026-05-01 |
| Trial of ProAgio in Advanced/Metastatic Colorectal Cancer ProAgio, FOLFIRI, Bevacizumab - Advanced Colorectal Cancer, Metastatic Colorectal Cancer | Phase 1 | Suspended | University of Alabama at Birmingham | 27 | 2025-07-17 | 2026-10-02 |
| Adaptive Radiation for Abdominopelvic Metastases Adaptive Stereotactic Body Radiation - Neoplasm - Soft Tissue Pelvis Malignant Secondary, Malignant Neoplasm of Stomach | Phase 1 | Suspended | Fox Chase Cancer Center | 30 | 2023-08-01 | 2026-11-02 |
| A Study of NPX267 for Subjects With Solid Tumors Known to Express HHLA2/B7-H7 NPX267 - Metastatic Malignant Neoplasm | Phase 1 | Suspended | NextPoint Therapeutics, Inc. | 131 | 2023-07-21 | 2025-06-27 |
| CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8 | Phase 1 | Suspended | National Cancer Institute (NCI) | 43 | 2023-06-12 | 2026-11-03 |
| The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors Fermented Wheat Germ Extract - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 | Suspended | University of California, Davis | 100 | 2023-06-02 | 2026-07-01 |
| AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Advanced Cholangiocarcinoma, Advanced Hepatocellular Carcinoma | Phase 1 | Suspended | University of Southern California | 36 | 2023-03-29 | 2026-08-17 |
| Switch Maintenance in Pancreatic ZIMBERELIMAB, DOMVANALIMAB, APX005M - Pancreatic Cancer, Adenocarcinoma of the Pancreas | Phase 1 / Phase 2 | Suspended | James Cleary, MD, PhD | 46 | 2022-11-30 | 2026-06-04 |
| Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer Vactosertib, Fludarabine Phosphate, Cyclophosphamide - Colorectal Cancer, Hematologic Malignancy | Phase 1 | Suspended | David Wald | 12 | 2022-09-09 | 2026-07-14 |
| A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer VS-6766/avutometinib, Cetuximab, Pill Diary - Colorectal Cancer, Colorectal Adenocarcinoma | Phase 1 / Phase 2 | Suspended | University of Chicago | 53 | 2022-08-22 | 2026-05-08 |
| A Pilot Study of Neoadjuvant Chemotherapy With or Without Camrelizumab for Locally Advanced Gastric Cancer camrelizumab+chemotherapy, Chemotherapy - Gastric Cancer | Phase 1 / Phase 2 | Suspended | Shanghai Minimally Invasive Surgery Center | 100 | 2022-07-01 | 2024-03-07 |
| GPC3-CAR-T Cells for the Hepatocellular Carcinoma GPC3-CAR-T cells - Hepatocellular Carcinoma | Phase 1 | Suspended | Beijing Tsinghua Chang Gung Hospital | 12 | 2022-06-10 | 2022-02-14 |
| AN0025 and Chemoradiotherapy Combination in Esophageal Cancer AN0025 - Esophageal Cancer | Phase 1 | Suspended | Adlai Nortye Biopharma Co., Ltd. | 32 | 2022-01-18 | 2025-02-13 |
| A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1 ChAdOx1-MAGEA3-NYESO (Route = IM injection, Dose = 5×10^10 vp), MVA-MAGEA3 (Route = IM injection, Dose = 1.3×10^8 pfu), Standard of care treatment - Non-small Cell Lung Cancer (NSCLC), Squamous Oesophageal Cancer | Phase 1 / Phase 2 | Suspended | Cancer Research UK | 15 | 2021-10-15 | 2026-04-06 |
| Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer Bosentan, Gemcitabine, Nab-paclitaxel - Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 | Suspended | City of Hope Medical Center | 21 | 2021-09-01 | 2026-06-15 |
| A Study of ABTL0812 in Pancreatic Cancer ABTL0812, Gemcitabine and nab-paclitaxel - Pancreatic Cancer | Phase 1 / Phase 2 | Suspended | Ability Pharmaceuticals SL | 60 | 2021-04-26 | 2025-10-01 |
| DNX-2440 for Resectable Colorectal Liver Metastasis DNX-2440 - Liver Metastases, Liver Metastasis Colon Cancer | Phase 1 | Suspended | DNAtrix, Inc. | 30 | 2021-02-15 | 2024-04-09 |
| Safety and Activity Study of HER2-Targeted Dual Switch CAR-T Cells (BPX-603) in Subjects With HER2-Positive Solid Tumors chimeric antigen receptor (CAR) T cell therapy - HER-2 Gene Amplification, HER2-positive Gastric Cancer | Phase 1 | Suspended | Bellicum Pharmaceuticals | 220 | 2020-12-07 | 2023-04-20 |
Showing 20 of 31. Sign in to see all of them.
Pancreatic Neoplasms (12) · Colorectal Neoplasms (8) · Stomach Neoplasms (6) · Carcinoma, Hepatocellular (4) · Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Carcinoma, Renal Cell (3) · Colonic Neoplasms (3) · Esophageal Neoplasms (3) · Neoplasms (3) · Prostatic Neoplasms (3) · Carcinoma, Transitional Cell (2) · Endometrial Neoplasms (2) · Lung Neoplasms (2) · Melanoma (2)
Digestive System Diseases (31) · Neoplasms by Site (31) · Neoplasms (28) · Gastrointestinal Diseases (17) · Gastrointestinal Neoplasms (17) · Endocrine Gland Neoplasms (13) · Endocrine System Diseases (13) · Neoplasms by Histologic Type (12) · Pancreatic Diseases (12) · Intestinal Diseases (11) · Intestinal Neoplasms (11) · Neoplasms, Glandular and Epithelial (11) · Colonic Diseases (10) · Carcinoma (9)
Gemcitabine (5) · 130-nm albumin-bound paclitaxel (3) · Specimen Handling (3) · Albumin-Bound Paclitaxel (2) · Cyclophosphamide (2) · Drug Therapy (2) · IFL protocol (2) · Interleukin-2 (2) · Magnetic Resonance Spectroscopy (2) · S 1 (combination) (2) · Taxes (2) · aldesleukin (2) · ABTL0812 (1) · Anticoagulants (1) · Automobiles (1)
Hokkaido Gastrointestinal Cancer Study Group (2) · ARCA Biopharma, Inc. (1) · Ability Pharmaceuticals SL (1) · Adlai Nortye Biopharma Co., Ltd. (1) · Akita University Hospital (1) · Beijing Tsinghua Chang Gung Hospital (1) · Bellicum Pharmaceuticals (1) · CMED HIFU Development Corporation (1) · Cancer Research UK (1) · City of Hope Medical Center (1) · DNAtrix, Inc. (1) · Dana-Farber Cancer Institute (1) · David Wald (1) · Envita Medical Center, Inc. (1) · Fox Chase Cancer Center (1)
United States (20) · China (6) · Japan (3) · Spain (1) · United Kingdom (1)
Masahiro Asaka, MD, PhD (2) · Andrew Poklepovic, MD (1) · Anthony B El-Khoueiry, MD (1) · Anuradha Krishnamurthy (1) · Ardaman S. Shergill, MD (1) · Benjamin Tomlinson, MD (1) · David Korn, D.O., M.D. (1) · Fiona Blackhall, Prof (1) · Geoffrey Shapiro, MD (1) · Gong Li, M.A. (1) · James Cleary, MD, PhD (1) · Jianming Xu, MD (1) · Jinbo Yue, Doctor (1) · Joan Robbins, Ph.d (1)
PMID 34482636, PMID 35537408, PMID 36356599
2019 (1), P30CA014089 (1), P30CA093373 (1), UM1CA186689 (1)