4 recruiting, 2 suspended, 1 active not recruiting, 1 completed. 6 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Recruiting 2, Active not recruiting 1, Completed 1, Not yet recruiting 1, Suspended 1 |
| Phase 2 | 4 | Suspended 2, Recruiting 1, Terminated 1 |
Follow Diffuse Midline Glioma: new trials by email Literature Review of Diffuse Midline Glioma trials Research Report on Diffuse Midline Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-09-30 | 2026-09-11 |
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-28 |
| Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor Gallium maltolate - High Grade Gliomas, Atypical Teratoid Rhabdoid Tumors (ATRT) | Phase 1 | Not yet recruiting | Sarah Rumler | 15 | 2026-05-15 | 2026-01-09 |
| GD2-CAR T Cells for Pediatric Brain Tumours GD2-CART01 (iC9-GD2-CAR T-cells) - Brain Tumor, Pediatric, Medulloblastoma, Childhood | Phase 1 | Recruiting | Bambino Gesù Hospital and Research Institute | 54 | 2023-11-09 | 2026-09-30 |
| Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors SC-CAR4BRAIN - Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 72 | 2023-05-05 | 2026-10-13 |
| A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG SONALA-001 (ALA) and MR-Guided Focused Ultrasound device (MRgFUS) - Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma | Phase 2 | Suspended | SonALAsense, Inc. | 15 | 2022-08-12 | 2024-09-19 |
| CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas Infusate with MTX110 and gadolinium, Convection-Enhanced Delivery (CED) - Diffuse Intrinsic Pontine Glioma, Diffuse Pontine and Thalamic Gliomas | Phase 1 | Completed | Luca Szalontay | 9 | 2020-03-10 | 2023-12-18 |
| Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel - Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma | Phase 1 | Recruiting | Seattle Children's Hospital | 90 | 2019-12-11 | 2026-04-13 |
| Oral ONC201 in Adult Recurrent Glioblastoma Dordaviprone (ONC201) - Glioblastoma, Diffuse Midline Glioma | Phase 2 | Terminated | Jazz Pharmaceuticals | 84 | 2016-01-01 | 2024-12-24 |
| International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant | Recruiting | Children's Hospital Medical Center, Cincinnati | 1500 | 2012-06-01 | 2026-10-26 |
Diffuse Intrinsic Pontine Glioma (9) · Brain Neoplasms (5) · Central Nervous System Neoplasms (3) · Glioma (3) · Medulloblastoma (3) · Recurrence (3) · Ependymoma (2) · Neoplasms, Germ Cell and Embryonal (2) · Rhabdoid Tumor (2) · Choroid Plexus Carcinoma (1) · Glioblastoma (1) · Neoplasms (1) · Neuroectodermal Tumors, Primitive (1) · Pinealoma (1)
Neoplasms by Histologic Type (10) · Neoplasms, Glandular and Epithelial (10) · Neoplasms, Nerve Tissue (10) · Neoplasms, Neuroepithelial (10) · Neuroectodermal Tumors (10) · Brain Diseases (9) · Brain Stem Neoplasms (9) · Central Nervous System Diseases (9) · Infratentorial Neoplasms (9) · Neoplasms (9) · Neoplasms by Site (9) · Nervous System Diseases (9) · Nervous System Neoplasms (9) · Neoplasms, Germ Cell and Embryonal (8) · Glioma (7)
Automobiles (1) · Gadolinium (1) · Nivolumab (1) · TIC10 compound (1) · Temozolomide (1) · gallium maltolate (1)
Seattle Children's Hospital (2) · Bambino Gesù Hospital and Research Institute (1) · BrainChild Bio, Inc (1) · Children's Hospital Medical Center, Cincinnati (1) · Jazz Pharmaceuticals (1) · Luca Szalontay (1) · Sarah Rumler (1) · SonALAsense, Inc. (1) · Washington University School of Medicine (1)
United States (8) · Italy (1)
Rebecca Ronsley, MD (2) · Cori Abikoff, MD (1) · Corina Andresen, MD (1) · Eric M Thompson, M.D. (1) · Lindsey Hoffman, DO (1) · Luca Szalontay, MD (1) · Trent Hummel, MD (1)
PMID 31456142, PMID 34003586, PMID 35468680, PMID 38335473, PMID 39775044, PMID 41798119
R01CA296813 (1), R44CA261516 (1)