2 suspended, 1 recruiting, 1 terminated. 4 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Suspended 2, Recruiting 1, Terminated 1 |
| Phase 1 | 1 | Suspended 1 |
Follow Diffuse Midline Glioma: new trials by email Literature Review of Diffuse Midline Glioma trials Research Report on Diffuse Midline Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-28 |
| A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG SONALA-001 (ALA) and MR-Guided Focused Ultrasound device (MRgFUS) - Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma | Phase 2 | Suspended | SonALAsense, Inc. | 15 | 2022-08-12 | 2024-09-19 |
| Oral ONC201 in Adult Recurrent Glioblastoma Dordaviprone (ONC201) - Glioblastoma, Diffuse Midline Glioma | Phase 2 | Terminated | Jazz Pharmaceuticals | 84 | 2016-01-01 | 2024-12-24 |
Diffuse Intrinsic Pontine Glioma (3) · Brain Neoplasms (1) · Central Nervous System Neoplasms (1) · Ependymoma (1) · Glioblastoma (1) · Medulloblastoma (1) · Neoplasms (1) · Recurrence (1)
Glioma (4) · Neoplasms by Histologic Type (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neoplasms, Neuroepithelial (4) · Neuroectodermal Tumors (4) · Brain Diseases (3) · Brain Stem Neoplasms (3) · Central Nervous System Diseases (3) · Infratentorial Neoplasms (3) · Neoplasms (3) · Neoplasms by Site (3) · Nervous System Diseases (3) · Nervous System Neoplasms (3)
Nivolumab (1) · TIC10 compound (1) · Temozolomide (1)
BrainChild Bio, Inc (1) · Jazz Pharmaceuticals (1) · SonALAsense, Inc. (1) · Washington University School of Medicine (1)
United States (4)
Cori Abikoff, MD (1) · Corina Andresen, MD (1) · Eric M Thompson, M.D. (1)
PMID 31456142, PMID 34003586, PMID 38335473
R01CA296813 (1), R44CA261516 (1)