56 completed. 56 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 56 | Completed 56 |
Follow Developmental Defects of Enamel: new trials by email Literature Review of Developmental Defects of Enamel trials Research Report on Developmental Defects of Enamel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effectiveness of Antivet Versus Opalustre® for the Management of Enamel Fluorosis/Discolored Enamel and Its Impact on Aesthetic Outcomes. Antivet, Opalusture - Fluorosis, Dental, Enamel Discoloration | Not applicable | Completed | October University for Modern Sciences and Arts | 59 | 2026-05-18 | 2026-07-16 |
| Impact of Glass-Hybrid Restoration on Occlusal Force Distribution and Masticatory Muscle Activity in Children With Molar-Incisor Hypomineralization Glass-Hybrid Restoration - Molar-Incisor Hypomineralization (MIH) | Not applicable | Completed | Marmara University | 5 | 2026-01-05 | 2026-05-12 |
| Intraosseus Injection Using Extra-short Needle Combined With Infiltration in Pediatric Patients With Molar Incisor Hypomineralization intraosseus anesthesia, Conventional nerve block - Molar Hypomineralization | Not applicable | Completed | Alexandria University | 26 | 2025-11-28 | 2026-10-29 |
| 3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children indirect- 3D digital scanning - Dental Caries in Children, Tooth Erosion | Not applicable | Completed | Indiana University | 36 | 2025-11-04 | 2026-05-06 |
| Educational Program to Improve Dental Interns, Knowledge ,Attitude and Awareness Toward Molar Incisor Hypo-mineralization. Educational Program on MIH - Molar Incisor Hypomineralization | Not applicable | Completed | Future University in Egypt | 200 | 2025-09-01 | 2025-11-19 |
| Etch-bleach-seal Technique in Managing Opacities Related MIH Using Icon® Sodium hypochlorite 5.25%, ICON resin infiltration Material group in vivo - Molar Incisor Hypomineralisation | Not applicable | Completed | Latakia University | 15 | 2025-08-25 | 2026-09-10 |
| Clinical Evaluation of Two Fissure Sealants (Resin Based Versus Giomer Fissure Sealants) on Molar Incisor Hypominerlisation Affected Permanent Molars (RCT) Resin based fissure sealant (Fisseal), Giomer based fissure sealant ( Beautisealant) - Molar Hypomineralization, Incisor, Fissure Sealant | Not applicable | Completed | National Research Centre, Egypt | 22 | 2025-06-29 | 2026-07-29 |
| Effect of Resin Infiltration on Hypersensitivity and Satisfaction in Children With Enamel Defects Resin infiltration - Molar Incisor Hypomineralisation, Enamel Hypoplasia | Not applicable | Completed | Gizem Tıraşçı | 40 | 2025-03-14 | 2026-03-30 |
| Digital Intraosseous Anesthesia in MIH-Affected Permanent Molars SleeperOne 5 Computer-Controlled Intraosseous Anaesthesia System, Conventional Maxillary Infiltration Anaesthesia, Conventional Inferior Alveolar Nerve Block Anaesthesia - Molar Incisor Hypomineralization | Not applicable | Completed | Ege University | 110 | 2025-01-15 | 2026-09-23 |
| Three Approaches of Resin Infiltration for MIH Incisor Opacities Resin infiltration, microabrasion, Etch-bleach - Molar Incisor Hypomineralization | Not applicable | Completed | Ain Shams University | 63 | 2024-07-01 | 2026-07-20 |
| Comparison of the Long-Term Success of Different CAD-CAM Blocks Used as Indirect Restorations in Molar Incisor Hypomineralized Teeth: A Split Mouth Study CAD-CAM, indirect restorations - Molar Hypomineralization, Incisor | Not applicable | Completed | Necmettin Erbakan University | 10 | 2024-06-15 | 2025-08-27 |
| Comparison of Two Minimally Invasive Approaches for Masking Molar-Incisor Hypomineralization Opacities Resin infiltration, Etch Bleach Seal Technique - Molar Incisor Hypomineralisation, Enamel Hypomineralization | Not applicable | Completed | Pamukkale University | 64 | 2024-05-06 | 2026-03-27 |
| Silver Diamine Fluoride in Molar-Incisor Hypomineralisation glass hybrid restorative system, Fluoride varnish + Glass hybrid restorative system - Molar-Incisor Hypomineralisation | Not applicable | Completed | Marmara University | 34 | 2024-04-01 | 2026-04-06 |
| Assessment of Inflammatory Biomarkers in Molar-Incisor Hypomineralization-Affected First Permanent Molars Pulpal Blood Sample - Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental | Not applicable | Completed | Marmara University | 83 | 2024-03-04 | 2025-12-15 |
| SleeperOne® 5 Intraosseous Anesthesia in MIH SleeperOne® 5 Computer-Controlled Intraosseous Anesthesia, Conventional Local Anesthesia - Molar Incisor Hypomineralisation | Not applicable | Completed | Ankara University | 35 | 2024-01-01 | 2026-08-06 |
| Comparing CAD/CAM vs Composite for Carious Hypomineralized Molars Evaluating Clinical Outcomes of Both Treatments. restoring the MIH affected young permanent molars using Direct nanohybrid flowable composite, restoring the MIH affected young permanent molars using IPS e.max CAD - Molar Incisor Hypomineralization | Not applicable | Completed | October University for Modern Sciences and Arts | 72 | 2023-12-01 | 2025-07-03 |
| Resin Infiltration vs Ionomer-Based Fluoride Varnish for the Prevention of Post-Eruptive Breakdown in Molars With Mild MIH Resin Infiltrant (Icon®, DMG), Varnish-Modified Glass Ionomer (Clinpro XT®, 3M) - Molar Hypomineralization, Incisor | Not applicable | Completed | Universidad Autonoma de San Luis Potosí | 17 | 2023-09-23 | 2026-03-04 |
| Effectiveness of Infiltration With Resin in Treatment of MIH Incisors in Children Showing Opacities white defects, yellow defects, brown defects - Children, Adult, Molar Incisor Hypomineralization | Not applicable | Completed | University of Valencia | 110 | 2023-09-19 | 2025-03-28 |
| Clinical Comparison of CAD/CAM Nanohybrid Composite and Hybrid Ceramic Overlays in Children With Molar-Incisor Hypomineralisation Semi-direct onlay restoration using CAD/CAM hybrid composite block, Semi-direct onlay restoration using CAD/CAM hybrid ceramic block - Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH) | Not applicable | Completed | Alp Akça | 20 | 2023-09-11 | 2026-10-20 |
| Resin Infiltration Versus Microabrasion With CPP-ACP for Fluorotic White Spot Lesions Resin infiltration, Enamel Microabrasion Plus CPP-ACP - Dental Fluorosis | Not applicable | Completed | Hue University of Medicine and Pharmacy | 42 | 2023-06-01 | 2026-07-15 |
Showing 20 of 56. Sign in to see all of them.
Molar Hypomineralization (41) · Fluorosis, Dental (10) · Dental Caries (5) · Dental Enamel Hypoplasia (5) · Dental Enamel Hypomineralization (4) · Dentin Sensitivity (4) · Tooth Erosion (2) · Amelogenesis Imperfecta (1) · Dental Plaque (1) · Dental Pulp Diseases (1) · Dentinogenesis Imperfecta (1) · Fluoride Poisoning (1) · Growth Disorders (1) · Heart Defects, Congenital (1) · Hypersensitivity (1)
Congenital Abnormalities (56) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (56) · Stomatognathic System Abnormalities (56) · Tooth Abnormalities (56) · Tooth Diseases (56) · Stomatognathic Diseases (55) · Dental Enamel Hypomineralization (49) · Tooth Demineralization (6) · Pathological Conditions, Signs and Symptoms (3) · Pathologic Processes (2) · Signs and Symptoms (2) · Body Weight (1) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1)
Enamel Microabrasion (3) · opalustre (2) · Blood Specimen Collection (1) · Composite Resins (1) · Control Groups (1) · Denture, Overlay (1) · Laser Therapy (1) · Low-Level Light Therapy (1) · adenylate isopentenyltransferase (1) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (1)
Marmara University (4) · Hacettepe University (3) · Ain Shams University (2) · Al-Azhar University (2) · Assistance Publique - Hôpitaux de Paris (2) · King Abdullah University Hospital (2) · October University for Modern Sciences and Arts (2) · Suez Canal University (2) · Universidade Federal do Paraná (2) · Alexandria University (1) · Alp Akça (1) · Ankara University (1) · Baskent University (1) · Beni-Suef University (1) · Cairo University (1)
Turkey (Türkiye) (16) · Egypt (15) · Brazil (4) · Jordan (3) · France (2) · Syria (2) · United States (2) · Ethiopia (1) · Italy (1) · Malaysia (1) · Mexico (1) · Pakistan (1) · Spain (1) · Vietnam (1)
Ola B. Al-Batayneh (2) · Abdulrhman S Hakmi (1) · Abeer Abd Elatiif, professor (1) · Abla A. Aly, Phd (1) · Aline Castilho, DDS (1) · Alp Abidin Atesci, PhD (1) · Andrea Scribante, DDS, PhD. (1) · Arif Bolaca, Dr (1) · Bennett T Amaechi, BDS, MS, PhD (1) · Beste Ozgur (1) · Carolina C Martins, PhD (1) · Didem Sakaryali, Asst.Prof. (1)
PMID 34743243, PMID 11641576, PMID 19893971, PMID 20403301, PMID 21180793, PMID 22163207, PMID 23675985, PMID 24197517, PMID 24588784, PMID 24683770, PMID 26163031, PMID 28721667, PMID 28762354, PMID 29566698, PMID 30883951, PMID 32149058, PMID 33804976, PMID 35790955, PMID 37400849, PMID 38797490, PMID 39367399, PMID 39511504, PMID 39685613, PMID 40335753, PMID 41469534, PMID 41597140, PMID 42565852, PMID 42771191, PMID 42794276