21 recruiting, 6 not yet recruiting, 2 suspended, 1 active not recruiting. 11 Phase 1, 10 Phase 2, 3 Not applicable, 2 Early Phase 1, 1 Phase 3.
Follow CRC (Colorectal Cancer): new trials by email Literature Review of CRC (Colorectal Cancer) trials Research Report on CRC (Colorectal Cancer)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Tunlametinib Combination Therapy in the Treatment of Second-line and Above Metastatic Colorectal Cancer Arm1, Arm 2, Arm 3 - CRC (Colorectal Cancer), BRAF | Phase 2 | Not yet recruiting | Sun Yat-sen University | 91 | 2026-11-30 | 2026-07-21 |
| A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) - NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 | Recruiting | Aktis Oncology, Inc. | 152 | 2026-11-01 | 2026-10-22 |
| A Study to Evaluate INCA33890 in the Treatment of Circulating Tumor DNA-Positive Stage II/III Microsatellite Stable Colorectal Cancer After Curative Resection and Chemotherapy INCA33890 - CRC (Colorectal Cancer) | Phase 2 | Not yet recruiting | Incyte Corporation | 40 | 2026-10-26 | 2026-09-22 |
| Feasibility of a Multi-Channel Intervention to Promote Colorectal Cancer Screening Among American Indians in Oklahoma Narrative Testimonial Video, v-TCHE Interaction - CRC Screening, CRC (Colorectal Cancer) | Not applicable | Recruiting | University of Oklahoma | 150 | 2026-08-30 | 2026-07-30 |
| Efficacy and Safety of Retlirafusp Alfa Plus Bevacizumab and Chemotherapy With or Without Short-Course Radiotherapy in Patients With CRCLM SCRT, Retlirafusp alfa Injection, Bevacizumab - CRC (Colorectal Cancer) | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2026-07-30 | 2026-09-22 |
| Monocentric Retrospective and Prospective Observational Study of Patients With Colorectal Cancer CRC (Colorectal Cancer) | Not yet recruiting | IRCCS San Raffaele | 2000 | 2026-06-01 | 2026-06-23 | |
| SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases CRC (Colorectal Cancer), Liver Metastases From Colorectal Primary Cancer | Not yet recruiting | Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis | 156 | 2026-05-10 | 2026-04-06 | |
| ENPP1/cGAS (EG) and FAP Expression Profiles in Solid Tumors: An Immunohistochemical Study in a Vietnamese Cohort IHC analysis for ENPP1, cGAS, and FAP expression - HCC - Hepatocellular Carcinoma, CRC (Colorectal Cancer) | Recruiting | Tam Anh Research Institute | 162 | 2026-03-19 | 2026-10-26 | |
| A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer INCA33890, Placebo, Bevacizumab - CRC (Colorectal Cancer) | Phase 3 | Recruiting | Incyte Corporation | 700 | 2026-03-05 | 2026-10-30 |
| A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer Mitomycin-PIPAC, Raltitrexed-PIPAC - Peritoneal Metastasis, CRC (Colorectal Cancer) | Phase 1 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 42 | 2026-01-01 | 2026-01-16 |
| Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer SHR-1701 neoadjuvant - CRC (Colorectal Cancer) | Phase 2 | Recruiting | Hong Qiu | 48 | 2025-12-20 | 2026-03-17 |
| Identification of New Non-invasive, Predictive, and Diagnostic Biomarkers for Colorectal Cancer CRC (Colorectal Cancer), Adenoma Colon | Recruiting | Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis | 60 | 2025-12-01 | 2025-12-19 | |
| Improving Rates of Diagnostic Colonoscopy in Native Americans Digital Outreach, In Person consultation - CRC Screening, CRC (Colorectal Cancer) | Not applicable | Not yet recruiting | University of Oklahoma | 164 | 2025-12-01 | 2025-09-30 |
| A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation GFH375 - Advanced Solid Tumors Cancer, PDAC | Phase 1 / Phase 2 | Recruiting | Genfleet Therapeutics (Shanghai) Inc. | 126 | 2025-10-21 | 2025-12-02 |
| A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors GFH276 - Cancer, PDAC | Phase 1 / Phase 2 | Not yet recruiting | Genfleet Therapeutics (Shanghai) Inc. | 450 | 2025-09-22 | 2025-09-30 |
| PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer PM8002, Chemotherapy Regimen 1, Chemotherapy Regimen 2 - CRC (Colorectal Cancer) | Phase 2 | Recruiting | Biotheus Inc. | 100 | 2025-08-19 | 2026-07-23 |
| A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors ALX2004 - NSCLC (Advanced Non-small Cell Lung Cancer), HNSCC | Phase 1 | Recruiting | ALX Oncology Inc. | 170 | 2025-08-18 | 2026-09-30 |
| An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia. NGM120 Q4W, NGM120 Q8W, Placebo given - Colorectal Cancer, CRC (Colorectal Cancer) | Phase 2 | Recruiting | NGM Biopharmaceuticals, Inc | 136 | 2025-06-25 | 2026-04-01 |
| A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors TGI-5 - CRC (Colorectal Cancer), Melanoma (Skin Cancer) | Phase 1 | Recruiting | Hefei TG ImmunoPharma Co., Ltd. | 194 | 2025-06-12 | 2026-01-29 |
| Autologous CAR-T Cells (WD-01) for Metastatic Colorectal Cancer An armored GCC targeting WD-01 CAR-T to treat cancer patients Other Name: - CRC (Colorectal Cancer), Metastatic Colorectal Cancer | Early Phase 1 | Suspended | Wondercel Biotech (ShenZhen) | 30 | 2025-05-18 | 2026-05-07 |
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