24 completed, 7 terminated, 5 unknown, 3 withdrawn. 41 Phase 2, 9 Phase 1, 6 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Next Generation T-cell Vaccine Against Coronavirus Disease (COVID-19) PepGNP-COVID19 (One vaccination), Water for injection (One vaccination), PepGNP-COVID19 (Two vaccinations) - Coronavirus, SARS-CoV-2 Infection | Phase 1 / Phase 2 | Not yet recruiting | Gylden Pharma Ltd | 110 | 2025-09-01 | 2025-02-24 |
| Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial Angiotensin 1-7, Placebos - Coronavirus, Respiratory Failure | Phase 2 / Phase 3 | Unknown | Erasme University Hospital | 60 | 2021-12-30 | 2021-08-02 |
| SPI-1005 Treatment in Moderate COVID-19 Patients Ebselen, Placebo - Covid19, Corona Virus Infection | Phase 2 | Enrolling by invitation | Sound Pharmaceuticals, Incorporated | 60 | 2021-10-12 | 2023-10-03 |
| SPI-1005 Treatment in Severe COVID-19 Patients Ebselen, Placebo - Covid19, Coronavirus | Phase 2 | Completed | Sound Pharmaceuticals, Incorporated | 25 | 2021-08-27 | 2026-06-29 |
| A Study to Evaluate the Safety, Immunogenicity, and Efficacy of UB-612 COVID-19 Vaccine UB-612, Placebo - Covid-19, SARS-CoV-2 | Phase 2 / Phase 3 | Withdrawn | Vaxxinity, Inc. | 2021-02-01 | 2022-04-04 | |
| Silmitasertib (CX-4945) in Patients With Severe Coronavirus Disease 2019 (COVID-19) Silmitasertib - Coronavirus | Phase 2 | Terminated | University of Arizona | 31 | 2021-01-21 | 2023-11-07 |
| Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS Umbilical Cord Lining Stem Cells (ULSC), Placebo (carrier control) - Covid19, Corona Virus Infection | Phase 1 / Phase 2 | Completed | Restem, LLC. | 17 | 2020-12-23 | 2024-04-09 |
| NeuroCovid Rehab and Recovery Related to COVID-19 Diagnosis Soterix taVNS model 0125-LTE Stimulator - Active-Active Group, Soterix taVNS model 0125-LTE Stimulator - Sham-Active Group - Coronavirus, Covid19 | Phase 2 | Completed | Medical University of South Carolina | 13 | 2020-11-19 | 2022-07-26 |
| Safety and Efficacy of Rayaldee for Treating Mild to Moderate COVID-19 Rayaldee, Placebo - COVID-19, Coronavirus | Phase 2 | Completed | OPKO Health, Inc. | 171 | 2020-11-02 | 2024-05-28 |
| Treatment of Patients With Mild Coronavirus-19 (COVID-19) Disease With Methotrexate Associated to LDL Like Nanoparticles (Nano-COVID19) Methotrexate-LDE phase 1, Methotrexate-LDE phase 2, Placebo-LDE phase 2 - Coronavirus, Inflammation | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 100 | 2020-10-27 | 2021-01-14 |
| Inflammatory Signal Inhibitors for COVID-19 (MATIS) Ruxolitinib, Fostamatinib, Standard of care - Coronavirus, Covid19 | Phase 1 / Phase 2 | Completed | Imperial College London | 185 | 2020-10-02 | 2025-11-18 |
| A Dose-Confirmation Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults for COVID-19 CVnCoV 6 μg, CVnCoV 12 μg, Hepatitis A vaccine - Coronavirus, Covid19 | Phase 2 | Completed | CureVac | 668 | 2020-09-21 | 2023-09-28 |
| Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 CYNK-001 - Coronavirus, Coronavirus Infection | Phase 1 / Phase 2 | Terminated | Celularity Incorporated | 7 | 2020-09-02 | 2026-06-26 |
| ACTIV-2: A Study for Outpatients With COVID-19 bamlanivimab 7000mg, BRII-196+BRII-198, AZD7442 (IV) - Coronavirus, Covid19 | Phase 2 / Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 4044 | 2020-08-19 | 2024-08-02 |
| Convalescent Plasma for Patients With COVID-19: A Randomized, Single Blinded, Parallel, Controlled Clinical Study Plasma, Standard Therapy - Coronavirus, Coronavirus Infection | Phase 2 / Phase 3 | Completed | Universidad del Rosario | 92 | 2020-08-08 | 2020-11-27 |
| Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Pemziviptadil (PB1046), Low Dose (10 mg) Control - Acute Respiratory Distress Syndrome, Coronavirus | Phase 2 | Terminated | PhaseBio Pharmaceuticals Inc. | 54 | 2020-07-15 | 2020-12-11 |
| Clinical Study of Recombinant Novel Coronavirus Vaccine Recombinant new coronavirus vaccine (CHO cell) low-dose group, Recombinant new coronavirus vaccine (CHO cells) high-dose group, Recombinant new coronavirus vaccine (CHO cells) placebo group - Coronavirus | Phase 2 | Unknown | Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd. | 900 | 2020-07-12 | 2020-12-03 |
| A Study to Evaluate Efficacy and Safety of PTC299 (Emvododstat) in Hospitalized Participants With Coronavirus (COVID-19) PTC299, SOC, Placebo - Pneumonia, COVID-19 | Phase 2 / Phase 3 | Terminated | PTC Therapeutics | 189 | 2020-07-09 | 2023-06-26 |
| COVID-19 Vaccine (ChAdOx1 nCoV-19) Trial in South African Adults With and Without HIV-infection ChAdOx1 nCoV-19, Normal saline 0.9% - Coronavirus | Phase 1 / Phase 2 | Unknown | University of Oxford | 2130 | 2020-06-24 | 2020-11-27 |
| A Study of Hydroxychloroquine, Vitamin C, Vitamin D, and Zinc for the Prevention of COVID-19 Infection Hydroxychloroquine, Vitamin C, Vitamin D - COVID-19, Coronavirus Infection | Phase 2 | Completed | ProgenaBiome | 254 | 2020-06-22 | 2025-06-05 |
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Coronavirus Infections (41) · COVID-19 (33) · Severe Acute Respiratory Syndrome (7) · Pneumonia (5) · Coronaviridae Infections (2) · Cytokine Release Syndrome (2) · Nidovirales Infections (2) · Pneumonia, Viral (2) · RNA Virus Infections (2) · Respiratory Distress Syndrome (2) · Respiratory Insufficiency (2) · Virus Diseases (2) · Acquired Immunodeficiency Syndrome (1) · Acute Lung Injury (1) · Amyotrophic Lateral Sclerosis (1)
Infections (41) · Coronaviridae Infections (39) · Nidovirales Infections (39) · RNA Virus Infections (39) · Virus Diseases (39) · Respiratory Tract Diseases (35) · Respiratory Tract Infections (34) · Lung Diseases (32) · Pneumonia, Viral (31) · Pneumonia (28) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Disease Attributes (3) · Respiration Disorders (3) · Inflammation (2)
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University of Oxford (3) · Sound Pharmaceuticals, Incorporated (2) · Universidad del Rosario (2) · Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd. (1) · Apellis Pharmaceuticals, Inc. (1) · Celularity Incorporated (1) · CureVac (1) · Erasme University Hospital (1) · Fundacion Clinic per a la Recerca Biomédica (1) · Gylden Pharma Ltd (1) · Henry Ford Health System (1) · Imperial College London (1) · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus (1) · Johns Hopkins University (1) · MGC Pharmaceuticals d.o.o (1)
United States (24) · Brazil (5) · Colombia (3) · South Africa (3) · United Kingdom (3) · Mexico (2) · Philippines (2) · Spain (2) · Argentina (1) · Australia (1) · Belarus (1) · Belgium (1) · Canada (1) · China (1) · France (1)
Andrew Pollard, Prof (2) · Juan M Anaya Cabrera, MD, PhD (2) · Miriam Treggiari, MD (2) · Adam Spivak, MD (1) · Akhtar Ashfaq, MD FACP FASN (1) · Alberto R Edison, MD (1) · Andrei Y Hancharou, Dr. (1) · Corey Casper, MD MPH (1) · David Smith, MD, MAS (1) · Deneen Vojta, MD (1) · Dr. Ryan O Lakin, MD JD (1) · Eduard A Dotsenko, Dr., prof. (1) · Eric J Lenze, MD (1) · Filippo Annoni, MD (1) · Geneva Tatem, MD (1)
PMID 33306989, PMID 33617777, PMID 34473343, PMID 34480858, PMID 32007143, PMID 32122636, PMID 32211963, PMID 32511534, PMID 32653469, PMID 32702298, PMID 32883593, PMID 32951151, PMID 33044747, PMID 33180097, PMID 33220855, PMID 33240091, PMID 33335322, PMID 33335323, PMID 33725432, PMID 33773111, PMID 33783269, PMID 33798499, PMID 33845867, PMID 34013969, PMID 34153264, PMID 34416193, PMID 34901997, PMID 34931202, PMID 34981077, PMID 35192543, PMID 35579509, PMID 35713300, PMID 35761219, PMID 35765566, PMID 35793677, PMID 35797235, PMID 35995785, PMID 36002874, PMID 36210483, PMID 36273491, PMID 36289399, PMID 36301549, PMID 36378539, PMID 36467293, PMID 36661240, PMID 36734509, PMID 36802755, PMID 36851662, PMID 37068272, PMID 37099295
U54GM104941 (1)