17 completed, 7 unknown, 4 recruiting, 3 terminated. 13 Not applicable, 7 Phase 1, 5 Phase 2, 2 Phase 4, 1 Early Phase 1.
Follow Corneal Disease: new trials by email Literature Review of Corneal Disease trials Research Report on Corneal Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness CorNeat KPro - Corneal Disease, Corneal Opacity | Not applicable | Terminated | CorNeat Vision Ltd. | 15 | 2024-06-27 | 2026-05-07 |
| Efficacy of 20% Autologous Serum Drops in the Treatment of Corneal Epitheliopathy Associated With Antihypertensive Glaucoma Drops. 20% ASED + AT, 0.9% NS + AT - Corneal Epitheliopathy, Glaucoma | Phase 4 | Unknown | Université de Sherbrooke | 25 | 2024-03-01 | 2024-03-05 |
| Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease Optical Coherence Tomography - Corneal Disease, Endothelial Corneal Dystrophy | Completed | Nitin Vaswani | 19 | 2023-10-12 | 2026-02-19 | |
| Evaluation of the Clinical Efficacy and Mechanisms of Cord Plasma Eye Drops in the Treatment of Neuropathic Corneal Pain Cord plasma eye drops - Neuropathic Pain, Corneal Disease | Not applicable | Recruiting | Singapore Eye Research Institute | 20 | 2023-09-16 | 2026-05-05 |
| A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma Belantamab Mafodotin-Blmf, Lenalidomide, Dexamethasone - Multiple Myeloma, Neoplasms | Phase 1 / Phase 2 | Recruiting | Hellenic Society of Hematology | 36 | 2023-07-14 | 2023-10-24 |
| QST for Corneal Nerve Function Quantitative Sensory Test - Corneal Disease, Neuropathy | Not applicable | Suspended | Tufts Medical Center | 108 | 2023-05-16 | 2026-01-08 |
| Prospective Study to Validate the Imaging Biomarker for NCP (R33) In vivo confocal microscopy (IVCM) - Dry Eye Syndromes, Corneal Disease | Suspended | Tufts Medical Center | 438 | 2022-12-16 | 2026-01-07 | |
| NGF Treatment for Patients With Neuropathic Corneal Pain Cenegermin-Bkbj - Corneal Disease, Neuropathy | Phase 1 | Withdrawn | Tufts Medical Center | 2022-11-01 | 2023-01-26 | |
| A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Pomalidomide and Dexamethasone in Patients With Relapsed/ Refractory Multiple Myeloma Previously Treated With One Line Therapy Who Are Lenalidomide Refractory Belantamab Mafodotin-Blmf, Daratumumab, Pomalidomide - Multiple Myeloma, Multiple Myeloma in Relapse | Phase 1 / Phase 2 | Not yet recruiting | Hellenic Society of Hematology | 48 | 2022-10-20 | 2022-10-17 |
| A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Lenalidomide and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Transplant Ineligible Belantamab Mafodotin-Blmf, Daratumumab, Lenalidomide - Multiple Myeloma, Neoplasms | Phase 1 / Phase 2 | Unknown | Hellenic Society of Hematology | 36 | 2022-04-13 | 2023-12-01 |
| Correlation Between Q-value Changes and Progression of Pediatric Keratoconus. Transepithelial Corneal Collagen Cross-linking, Scheimpflug camera - Keratoconus, Collagen Diseases | Completed | Benha University | 9 | 2021-10-09 | 2021-11-10 | |
| Efficacy of Xiidra in Dry Eye Disease After Collagen Cross Linking Xiidra 5% Ophthalmic Solution - Corneal Disease | Phase 4 | Unknown | Benha University | 40 | 2021-02-01 | 2021-09-16 |
| First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness CorNeat KPro - Corneal Disease, Corneal Opacity | Not applicable | Terminated | CorNeat Vision Ltd. | 10 | 2021-01-03 | 2024-09-24 |
| Artificial Intelligence for Screening of Multiple Corneal Diseases Cornea diseases diagnosed by artificial intelligence algorithm - Deep Learning, Corneal Disease | Recruiting | Tianjin Eye Hospital | 3000 | 2020-12-06 | 2024-11-04 | |
| Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany), Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany), Optic nerve head measurement - Corneal Ectasia, Corneal Disease | Completed | Technische Universität Dresden | 372 | 2020-07-09 | 2022-08-11 | |
| Agreement and Precision Study of the Nidek Mirante Nidek Mirante, Optovue RTVue XR Avanti, Optos P200DTx - Glaucoma, Retinal Disease | Not applicable | Completed | Nidek Co. LTD. | 170 | 2020-01-25 | 2023-08-24 |
| Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus Epi-on PiXL, Epi-Off PiXL - Keratoconus, Corneal Crosslinking | Not applicable | Completed | Umeå University | 32 | 2019-04-02 | 2023-09-01 |
| Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty Femtosecond Laser, Trephine blade - Keratoconus, Fuchs Dystrophy | Not applicable | Unknown | University of Southampton | 30 | 2019-02-01 | 2020-12-22 |
| Rapid Computerized Visual Acuity Test Computerized visual acuity assessment program - Vision Disorders, Refractive Errors | Unknown | Rambam Health Care Campus | 200 | 2019-01-01 | 2022-07-07 | |
| Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Systane Complete, Systane Ultra - Dry Eye Syndromes, Keratoconjunctivitis Sicca | Not applicable | Completed | Ohio State University | 24 | 2018-12-05 | 2019-05-23 |
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Corneal Diseases (37) · Glaucoma (6) · Dry Eye Syndromes (5) · Keratoconus (5) · Retinal Diseases (5) · Blood Protein Disorders (3) · Cataract (3) · Corneal Injuries (3) · Corneal Opacity (3) · Hematologic Diseases (3) · Multiple Myeloma (3) · Neoplasms (3) · Neoplasms, Plasma Cell (3) · Paraproteinemias (3) · Astigmatism (2)
Eye Diseases (35) · Ocular Hypertension (6) · Lacrimal Apparatus Diseases (5) · Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Cardiovascular Diseases (4) · Conjunctival Diseases (4) · Immune System Diseases (4) · Vascular Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Craniocerebral Trauma (3) · Eye Diseases, Hereditary (3) · Eye Injuries (3) · Facial Injuries (3) · Genetic Diseases, Inborn (3)
Dexamethasone (3) · Corneal Cross-Linking (2) · Corneal Topography (2) · Lenalidomide (2) · Tomography (2) · daratumumab (2) · Betamethasone (1) · Contact Lenses (1) · Levofloxacin (1) · Mitomycin (1) · Ophthalmic Solutions (1) · Tomography, Optical Coherence (1) · Vision, Ocular (1) · cenegermin (1) · lifitegrast (1)
National Eye Institute (NEI) (4) · Benha University (3) · Hellenic Society of Hematology (3) · Nidek Co. LTD. (3) · Tufts Medical Center (3) · CorNeat Vision Ltd. (2) · Technische Universität Dresden (2) · Centre Hospitalier Universitaire de Saint Etienne (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Federal University of São Paulo (1) · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus (1) · Klinikum Klagenfurt am Wörthersee (1) · LenSx Lasers Inc. (1) · Nitin Vaswani (1) · Ohio State University (1)
United States (15) · China (3) · France (3) · Israel (3) · Canada (2) · Germany (2) · Greece (2) · Netherlands (2) · United Arab Emirates (2) · Austria (1) · Belarus (1) · Egypt (1) · Italy (1) · Singapore (1) · Sweden (1)
Evangelos Terpos, Prof (3) · Pedram Hamrah, MD (3) · Ahmed A Tabl, MD (1) · Anders Behndig, MD, PhD (1) · Edward J Holland, MD (1) · Eytan Z Blumenthal, MD (1) · Frederik Raiskup, MD, PhD (1) · Igor Volotovski, Prof (1) · James F Hejtmancik, M.D. (1) · Jonathan H Lass, MD (1) · Liudmila Marchenko, Prof (1) · Mark J Mannis, MD (1) · Mona Harissi-Dagher, MD (1)
PMID 14289827, PMID 15745770, PMID 15829793, PMID 16371775, PMID 16603465, PMID 18387407, PMID 18387408, PMID 19056078, PMID 19395036, PMID 19724216, PMID 20065219, PMID 21555600, PMID 22262218, PMID 22488114, PMID 23343949, PMID 23493999, PMID 24246825, PMID 24246826, PMID 25119961, PMID 25322173, PMID 25425307, PMID 25439611, PMID 28475702, PMID 32852646, PMID 34012881, PMID 34059127, PMID 35035046, PMID 35606839
R33NS113341 (1), U10EY012358 (1), U10EY012728 (1)