873 completed, 214 terminated, 162 recruiting, 133 unknown. 1580 Phase 2, 311 Phase 1, 145 Phase 3.
Follow Connective Tissue Diseases: new trials by email Literature Review of Connective Tissue Diseases trials Research Report on Connective Tissue Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid | Phase 1 / Phase 2 | Withdrawn | Crystal Lederhos Smith | 2028-07-15 | 2026-09-23 | |
| The Primary Objective of the Trial is to Evaluate the Effect of the Addition of Belantamab Mafodotin to Standard of Care Therapy on the Titres of Serum Anti-dsDNA Antibodies in Patients With Previously Treated SLE. belantamab mafodotin to the existing stable standard background therapy - SLE - Systemic Lupus Erythematosus | Phase 2 | Not yet recruiting | Medical Association for the Study of Cancer Biology and Treatment | 12 | 2027-02-01 | 2026-09-28 |
| Efficacy and Safety Study of L608 in Patients With Systemic Sclerosis-associated Digital Ulcers L608, Placebo - Systemic Sclerosis | Phase 2 | Not yet recruiting | Pharmosa Biopharm Inc. | 40 | 2027-02-01 | 2026-11-09 |
| Single Injection of rAAV9-CMV-hNAGLUop Gene for Patients With Mucopolysaccharidosis (MPS) IIIB rAAV9-CMV-hNAGLUop - Sanfilippo Syndrome (MPS III) | Phase 1 / Phase 2 | Not yet recruiting | NeuroGT | 9 | 2027-01-18 | 2026-09-14 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) Bone marrow-derived mesenchymal stromal cells (MSCs) - Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III | Phase 1 / Phase 2 | Not yet recruiting | Emory University | 12 | 2027-01-01 | 2026-05-08 |
| An Open-label Phase I/II Safety and Feasibility Basket Study of UKT-CART19.1 CAR-T cells targeting CD19 - Pemphigus Vulgaris (PV), ANCA Associated Vasculitis (AAV) | Phase 1 / Phase 2 | Not yet recruiting | University Hospital Tuebingen | 36 | 2027-01-01 | 2026-11-12 |
| A Pilot Multicentric Open Study Assessing the Efficacy and Safety of NEMOlizumab in Patients ≥ 12yo With Dystrophic Epidermolysis Bullosa Neolizumab - Dystrophic Epidermolysis Bullosa | Phase 2 / Phase 3 | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 15 | 2026-12-31 | 2026-11-09 |
| A Study to Evaluate the Safety and Efficacy (How Well the Study Treatment Works) of ABBV-2294 in Adult Participants With Systemic Sclerosis That Are Currently Receiving Local Standard of Care Treatment, and to Determine the Best Dose of ABBV-2294 to be Evaluated Further. ABBV-722, Upadacitinib, Placebo for ABBV-722 - Systemic Sclerosis | Phase 2 / Phase 3 | Not yet recruiting | AbbVie | 580 | 2026-12-11 | 2026-11-12 |
| Platform Study of Targeted Therapies for Adults With Moderately to Severely Active Rheumatoid Arthritis ABBV-722, Upadacitinib - Rheumatoid Arthritis | Phase 2 | Not yet recruiting | AbbVie | 250 | 2026-12-07 | 2026-11-10 |
| Mycophenolate After Stem Cell Transplant for Systemic Sclerosis Mycophenolate Mofetil 1000 mg twice daily - Systemic Sclerosis (SSc) | Phase 2 | Not yet recruiting | Ottawa Hospital Research Institute | 6 | 2026-12-01 | 2026-10-19 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Evaluation of Dapagliflozin and Empagliflozin as Adjunctive Therapy to Methotrexate in Patients With Rheumatoid Arthritis Dapagliflozin, Empagliflozin, Methotrexate - Rheumatoid Arthritis (RA) | Phase 2 | Not yet recruiting | Al-Azhar University | 90 | 2026-12-01 | 2026-10-08 |
| Hyaluronidase Injections for Sclerodactyly in Patients With Scleroderma hyaluronidase - Scleroderma, Sclerodactyly | Phase 2 | Not yet recruiting | Stanford University | 10 | 2026-12-01 | 2026-11-06 |
| A Clinical Trial of MK-8690 in Participants With Rheumatoid Arthritis (MK-8690-004) MK-8690, Placebo, Methotrexate (MTX) - Rheumatoid Arthritis | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 60 | 2026-11-23 | 2026-10-26 |
| A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases PF-08154225 - Systemic Lupus Erythematosus, Rheumatoid Arthritis | Phase 1 / Phase 2 | Not yet recruiting | Pfizer | 54 | 2026-11-19 | 2026-10-01 |
| FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM) FISH OIL 500MG OMEGA-3 SOFT GEL MINIS, Placebo - Dermatomyositis (DM), Juvenile Dermatomyositis (JDM) | Phase 2 | Recruiting | National Institute of Environmental Health Sciences (NIEHS) | 3000 | 2026-11-18 | 2026-11-13 |
| Study of Afimetoran in Adults With Cutaneous Lupus Erythematosus Afimetoran, Placebo - Cutaneous Lupus Erythematosus (CLE), Systematic Lupus Erythematosus | Phase 2 / Phase 3 | Recruiting | Beeline Medicines Corporation | 390 | 2026-11-03 | 2026-11-10 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
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Arthritis, Rheumatoid (569) · Lupus Erythematosus, Systemic (268) · Scleroderma, Systemic (165) · Lupus Nephritis (100) · Scleroderma, Diffuse (92) · Sjogren's Syndrome (78) · Arthritis (66) · Autoimmune Diseases (62) · Dermatomyositis (61) · Keloid (37) · Epidermolysis Bullosa Dystrophica (33) · Arthritis, Juvenile (31) · Mucopolysaccharidosis II (31) · Inflammation (29)
Skin and Connective Tissue Diseases (1578) · Immune System Diseases (992) · Autoimmune Diseases (932) · Musculoskeletal Diseases (797) · Joint Diseases (680) · Rheumatic Diseases (669) · Arthritis (628) · Skin Diseases (382) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (211) · Pathological Conditions, Signs and Symptoms (205) · Genetic Diseases, Inborn (178) · Pathologic Processes (164) · Nutritional and Metabolic Diseases (138) · Nervous System Diseases (133)
Methotrexate (81) · Rituximab (47) · Mycophenolic Acid (37) · Cyclophosphamide (35) · Adalimumab (27) · Prednisone (26) · Abatacept (23) · tofacitinib (23) · belimumab (18) · Methylprednisolone (17) · Folic Acid (16) · Saline Solution (16) · Etanercept (15) · Prednisolone (15) · tocilizumab (15)
Novartis Pharmaceuticals (38) · Pfizer (35) · Amgen (28) · National Institute of Allergy and Infectious Diseases (NIAID) (25) · GlaxoSmithKline (24) · Bristol-Myers Squibb (23) · AbbVie (18) · AstraZeneca (17) · Eli Lilly and Company (16) · Hoffmann-La Roche (16) · Biogen (15) · Janssen Research & Development, LLC (15) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (15) · Assistance Publique - Hôpitaux de Paris (14) · Peking University People's Hospital (14)
United States (796) · Poland (265) · Germany (261) · United Kingdom (238) · Spain (232) · France (193) · Mexico (175) · China (164) · Canada (161) · Hungary (155) · Italy (148) · Czechia (141) · Argentina (140) · Russia (119) · Australia (115)
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