20 completed, 7 recruiting, 6 unknown, 5 terminated. 12 Not applicable, 4 Phase 4, 3 Phase 2, 3 Phase 3, 1 Phase 1.
Follow Clinically Isolated Syndrome: new trials by email Literature Review of Clinically Isolated Syndrome trials Research Report on Clinically Isolated Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care Cohort - Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive | Not yet recruiting | Luxembourg Institute of Health | 100 | 2026-12-01 | 2026-09-22 | |
| Clinical Impact Through AI-assisted MS Care - A Prospective Multi-center Study quantitative brain MRI (icobrain mr), Standard of Care (SOC) - Multiple Sclerosis, Radiologically Isolated Syndrome | Not applicable | Enrolling by invitation | icometrix | 750 | 2025-10-09 | 2025-12-09 |
| Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome Optic nerve MRI sequence - Clinically Isolated Syndrome, Multiple Sclerosis | Not applicable | Recruiting | University Hospital, Lille | 200 | 2025-07-17 | 2025-08-24 |
| Glymphatic MRI in Clinically Isolated Syndrome Magnetic Resonance Imaging - Clinically Isolated Syndrome | Active not recruiting | University of Exeter | 30 | 2024-05-01 | 2026-05-08 | |
| Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study. Multiple Sclerosis, NMO Spectrum Disorder | Recruiting | icometrix | 7000 | 2024-03-01 | 2025-12-12 | |
| Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating Diseases Multiple Sclerosis, MS, Neuromyelitis Optica Spectrum Disorders | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 450 | 2024-01-01 | 2024-08-07 | |
| A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis Relapsing Multiple Sclerosis, Clinically Isolated Syndrome | Completed | Novartis | 113 | 2023-04-23 | 2024-05-02 | |
| Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD20 Therapies Relapsing Multiple Sclerosis, Clinically Isolated Syndrome | Completed | Novartis | 326 | 2022-10-11 | 2024-07-29 | |
| Implementation of a Novel Functional Eye-Tracking Biomarker for Multiple Sclerosis Eye-tracking - Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis | Unknown | McGill University | 120 | 2022-09-01 | 2023-11-09 | |
| Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis Eye tracking, Microperimetry, Optical coherence tomography (OCT) - Multiple Sclerosis, Clinically Isolated Syndrome | Enrolling by invitation | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 120 | 2022-06-13 | 2025-05-16 | |
| A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy Ocrelizumab - Multiple Sclerosis, Clinically Isolated Syndrome | Phase 4 | Completed | Hoffmann-La Roche | 70 | 2022-04-13 | 2026-04-15 |
| China National Registry of Neuro-Inflammatory Diseases Intravenous steroid - Multiple Sclerosis, NMO Spectrum Disorder | Recruiting | Beijing Tiantan Hospital | 10000 | 2021-12-15 | 2023-07-21 | |
| Autoimmune Intervention Mastery Course Study Immediate Autoimmune Intervention Mastery Course (AIM), Immediate Question and Answer sessions. (AIM Q and A sessions), Delayed Autoimmune Intervention Mastery Course (delayed AIM course) - Multiple Sclerosis, Clinically Isolated Syndrome | Not applicable | Active not recruiting | Terry L. Wahls | 400 | 2021-12-01 | 2026-09-18 |
| MS-ResearchBiomarkerS Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | Recruiting | Cedars-Sinai Medical Center | 1000 | 2021-11-11 | 2024-02-06 | |
| Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis blood sample, cerebro-spinal fluid - Multiple Sclerosis, Clinically Isolated Syndrome | Not applicable | Recruiting | University Hospital, Bordeaux | 150 | 2021-09-30 | 2026-10-26 |
| A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab Ocrelizumab - Multiple Sclerosis, Clinically Isolated Syndrome | Phase 4 | Completed | Hoffmann-La Roche | 26 | 2021-09-16 | 2026-01-14 |
| Assessing the Feasibility of the MSPT Device in Routine Clinical Practice in the Swiss Healthcare System MSPT - Multiple Sclerosis, Clinically Isolated Syndrome | Terminated | Insel Gruppe AG, University Hospital Bern | 182 | 2020-10-16 | 2023-03-10 | |
| Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onset Ocrelizumab - Relapsing Multiple Sclerosis, Clinically Isolated Syndrome | Phase 4 | Active not recruiting | University of California, San Francisco | 30 | 2020-08-30 | 2026-01-26 |
| Ocrelizumab in Breastmilk Ocrelizumab - Multiple Sclerosis, Clinically Isolated Syndrome | Completed | University of California, San Francisco | 30 | 2020-08-07 | 2022-12-16 | |
| Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis Therapeutic diet and lifestyle - Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis | Not applicable | Active not recruiting | Terry L. Wahls | 44 | 2020-05-01 | 2025-12-26 |
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Multiple Sclerosis (35) · Multiple Sclerosis, Relapsing-Remitting (14) · Multiple Sclerosis, Chronic Progressive (8) · Demyelinating Diseases (5) · Neuromyelitis Optica (5) · Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (4) · Autoimmune Diseases (2) · Autoimmune Diseases of the Nervous System (2) · Encephalomyelitis, Acute Disseminated (2) · Nerve Degeneration (2) · Breast Feeding (1) · Demyelinating Autoimmune Diseases, CNS (1) · Disease Progression (1) · Fibromyalgia (1) · Lacerations (1)
Immune System Diseases (41) · Demyelinating Autoimmune Diseases, CNS (40) · Nervous System Diseases (40) · Autoimmune Diseases (39) · Autoimmune Diseases of the Nervous System (39) · Demyelinating Diseases (36) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Disease Attributes (12) · Chronic Disease (11) · Cranial Nerve Diseases (7) · Eye Diseases (7) · Multiple Sclerosis (6) · Optic Nerve Diseases (6) · Myelitis, Transverse (5)
ocrelizumab (4) · Interferon beta-1a (3) · Eye-Tracking Technology (2) · Antirheumatic Agents (1) · Blood Specimen Collection (1) · Cholecalciferol (1) · Cohort Studies (1) · Diet, Gluten-Free (1) · Hematologic Tests (1) · Immunoglobulins (1) · Magnetic Resonance Spectroscopy (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Minocycline (1) · Plasmapheresis (1)
Merck KGaA, Darmstadt, Germany (3) · University of California, San Francisco (3) · Hoffmann-La Roche (2) · Lille Catholic University (2) · Novartis (2) · Terry L. Wahls (2) · University Hospital, Lille (2) · icometrix (2) · Albert Christian Ludolph, Prof. (1) · American University of Beirut Medical Center (1) · Association de Recherche Bibliographique pour les Neurosciences (1) · Beijing Tiantan Hospital (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Universitaire de Nice (1) · Centre Hospitalier Universitaire de Nīmes (1)
United States (17) · France (9) · Germany (9) · Canada (4) · Spain (4) · Czechia (3) · Italy (3) · Belgium (2) · China (2) · Lebanon (2) · Poland (2) · Switzerland (2) · United Kingdom (2) · Argentina (1) · Austria (1)
Riley Bove, MD, MSc (2) · Terry L Wahls, MD (2) · Albert Verier, MD (1) · Bertrand Bourre, MD (1) · Brooke Guerrero, MD (1) · Bruce Cree, MD, PhD, MAS (1) · Bruno Brochet, MD, PhD (1) · Christian Confavreux, MD (1)
PMID 23981773, PMID 28039317, PMID 30426289, PMID 31832624, PMID 33298133, PMID 37311951, PMID 37399671, PMID 37675826, PMID 38222092, PMID 38453475, PMID 38700322, PMID 38959589, PMID 39250723, PMID 39329242, PMID 39464680, PMID 41841206
2009 (1), 2014 (1)