9 unknown. 9 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Unknown 9 |
| Phase 2 | 7 | Unknown 7 |
Follow Chronic Limb-Threatening Ischemia: new trials by email Literature Review of Chronic Limb-Threatening Ischemia trials Research Report on Chronic Limb-Threatening Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Apixaban in Reducing Restenosis and Limb Loss in PAD Patients. Apixaban, ASA, Clopidogrel 75mg - Critical Limb Ischemia | Phase 3 | Unknown | Science Valley Research Institute | 200 | 2020-01-09 | 2021-04-20 |
| Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs Allogeneic Mesenchymal Stromal Cell, Placebo - Peripheral Arterial Disease, Cardiovascular Diseases | Phase 2 / Phase 3 | Unknown | Martin Teraa, MD, PhD | 60 | 2018-12-01 | 2018-05-03 |
| Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With No-option Critical Limb Ischemia (N-O CLI) CardioCell, Placebos - Critical Limb Ischemia | Phase 2 / Phase 3 | Unknown | John Paul II Hospital, Krakow | 50 | 2018-04-19 | 2021-04-09 |
| Critical Limb Ischemia Rapid Delivery by SurgWerks-CLI Kit and VXP System Autologous Bone Marrow Concentrate (aBMC), Placebo Control (diluted autologous peripheral blood) - Critical Limb Ischemia (CLI) | Phase 3 | Unknown | Cesca Therapeutics, Inc. | 224 | 2017-01-01 | 2016-07-28 |
| An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK) Ranger SL DEB - Lower Limb Ischemia, Peripheral Vascular Diseases | Phase 2 / Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 30 | 2016-11-01 | 2018-05-18 |
| VADOplex Critical Limb Ischemia Study VADOplex system - Peripheral Artery Disease, Quality of Life | Phase 2 / Phase 3 | Unknown | Asklepios Kliniken Hamburg GmbH | 38 | 2013-10-01 | 2014-01-13 |
| Distal Venous Arterialisation of Ischemic Limb distal venous arterialisation, Aspirin - Critical Limb Ischemia | Phase 2 / Phase 3 | Unknown | Clinical Centre of Serbia | 30 | 2009-09-01 | 2010-09-30 |
| Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia bone marrow derived mononuclear cells, placebo - Intermittent Claudication, Peripheral Vascular Diseases | Phase 2 / Phase 3 | Unknown | Leiden University Medical Center | 108 | 2007-10-01 | 2011-07-06 |
| PTA and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia PTA with placement of paclitaxel-eluting stent, PTA - Peripheral Vascular Disease | Phase 2 / Phase 3 | Unknown | Netherlands Society for Interventional Radiology | 144 | 2007-08-01 | 2020-09-16 |
Peripheral Arterial Disease (3) · Peripheral Vascular Diseases (3) · Cardiovascular Diseases (1) · Intermittent Claudication (1) · Peripheral Arterial Occlusive Disease 1 (1) · Vascular Diseases (1)
Arterial Occlusive Diseases (9) · Arteriosclerosis (9) · Atherosclerosis (9) · Chronic Disease (9) · Disease Attributes (9) · Ischemia (9) · Pathologic Processes (9) · Pathological Conditions, Signs and Symptoms (9) · Cardiovascular Diseases (8) · Vascular Diseases (8) · Peripheral Arterial Disease (6) · Peripheral Vascular Diseases (6) · Signs and Symptoms (1)
Aspirin (1) · Clopidogrel (1) · apixaban (1)
Asklepios Kliniken Hamburg GmbH (1) · Assistance Publique - Hôpitaux de Paris (1) · Cesca Therapeutics, Inc. (1) · Clinical Centre of Serbia (1) · John Paul II Hospital, Krakow (1) · Leiden University Medical Center (1) · Martin Teraa, MD, PhD (1) · Netherlands Society for Interventional Radiology (1) · Science Valley Research Institute (1)
Netherlands (3) · Brazil (1) · France (1) · Germany (1) · Poland (1) · Serbia (1)
Dalip Sethi, PhD (1) · Gert Jan de Borst, MD, PhD (1) · Hans Van Overhagen, MD PhD (1) · Holger Lawall, MD (1) · Jan HN Lindeman, MD, PhD (1) · Marianne C Verhaar, MD, PhD (1) · Predrag Vl Djoric, MD (1)
PMID 19700099, PMID 26861113, PMID 28411244, PMID 29242062, PMID 30004916, PMID 32730905, PMID 35802393