42 completed. 42 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 42 | Completed 42 |
Follow Chronic Hepatitis b: new trials by email Literature Review of Chronic Hepatitis b trials Research Report on Chronic Hepatitis b
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Serum Vitamin D Level on the Efficacy of Peg-interferon Treatment in CHB Vitamin D - Chronic Hepatitis b | Phase 4 | Completed | Third Affiliated Hospital, Sun Yat-Sen University | 90 | 2018-12-01 | 2023-03-03 |
| Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B Tenofovir disoproxil 245mg, Tenofovir disoproxil fumarate 300mg - Chronic Hepatitis b | Phase 4 | Completed | Samjin Pharmaceutical Co., Ltd. | 113 | 2018-10-12 | 2025-05-16 |
| Clinical Trial to Evaluate the Efficacy and Safety of TenofoBell® Tablet in Chronic Hepatitis B Patients Experimental - Chronic Hepatitis B | Phase 4 | Completed | Chong Kun Dang Pharmaceutical | 78 | 2018-09-20 | 2021-07-28 |
| Change of Renal Function and Bone Mineral Density in CHB Patients Switch From TDF to TAF vs. Maintaining TDF Tenofovir alafenamide(TAF), Tenofovir disoproxil fumarate(TDF) - Chronic Hepatitis B | Phase 4 | Completed | Humanity and Health Research Centre | 575 | 2017-12-01 | 2025-03-26 |
| A phase4 Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B Tenofovir disoproxil 245mg, Tenofovir disoproxil fumarate 300mg - Chronic Hepatitis B | Phase 4 | Completed | Samjin Pharmaceutical Co., Ltd. | 118 | 2017-11-20 | 2022-04-01 |
| Switching From TDF to TAF vs. Maintaining TDF in Chronic Hepatitis B With Resistance to Adefovir or Entecavir. Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate - Chronic Hepatitis b | Phase 4 | Completed | Young-Suk Lim | 174 | 2017-10-26 | 2021-03-29 |
| Pegylated Interferon(Peg-IFN) in Reducing Relapse Rate in Patients After Discontinuation of NUC Therapy PegIFN alfa-2a - Chronic Hepatitis B | Phase 4 | Completed | Huashan Hospital | 180 | 2015-10-01 | 2022-10-31 |
| Efficacy of HBV Vaccine in Consolidation of Nucleos(t)Ide Analogues Therapy Engerix-B, Tenofovir, Entecavir - Chronic Hepatitis B | Phase 4 | Completed | Chang Gung Memorial Hospital | 116 | 2015-05-01 | 2019-07-30 |
| Efficacy of Switching or Adding Pegylated Interferon in Chronic Hepatitis B Patients on Long Term Oral Antiviral Therapy peg-interferon alpha 2b, 1.5mcg/kg s/c given weekly, Nucleos(t)ide analogue therapy - Chronic Hepatitis B | Phase 4 | Completed | Seng Gee Lim | 254 | 2014-01-01 | 2019-09-24 |
| Tenofovir Disoproxil Fumarate vs. Entecavir in Chronic Hepatitis B Patients With Partial Virologic Response to Entecavir tenofovir, entecavir - Chronic Hepatitis B | Phase 4 | Completed | Korea University | 60 | 2013-04-01 | 2016-11-09 |
| TDF VS LAM + ADV in LAM + ADV Treated LAM-resistant CHB Patients With Undetectable Hepatitis B Virus DNA Lamivudine plus adefovir, Tenofovir - Chronic Hepatitis B | Phase 4 | Completed | Keimyung University Dongsan Medical Center | 171 | 2012-11-01 | 2016-10-28 |
| Lowering Viral Load With Nucleos(T)Ide Analogues Prior to Peginterferon Treatment to Ncrease Sustained Response in CHB PegIFN alfa-2b - Chronic Hepatitis B | Phase 4 | Completed | Foundation for Liver Research | 82 | 2012-06-01 | 2019-01-04 |
| PEG-interferon Alfa-2a add-on Study in HBeAg Negative Chronic Hepatitis B Patients Peginterferon alfa-2a, Nucleos(t)ide analogue - Chronic Hepatitis B | Phase 4 | Completed | Foundation for Liver Research | 90 | 2012-05-25 | 2019-11-08 |
| Tenofovir in Chronic Hepatitis B With Mild ALT Elevation tenofovir disoproxil fumarate 300mg per day, Placebo - Chronic Hepatitis B | Phase 4 | Completed | E-DA Hospital | 160 | 2012-01-01 | 2019-02-12 |
| Stopping TDF Treatment After Long Term Virologic Suppression in HBeAg-negative CHB TDF, Stop TDF - Chronic Hepatitis B | Phase 4 | Completed | Gilead Sciences | 43 | 2011-04-26 | 2017-08-29 |
| Efficacy & Safety of Tenofovir Disoproxil Fumarate (TDF) Plus Peginterferon α-2a (Peg-IFN) Versus TDF or Peg-IFN Monotherapy in Chronic Hepatitis B TDF, Peg-IFN - Chronic Hepatitis B | Phase 4 | Completed | Gilead Sciences | 751 | 2011-04-01 | 2016-08-26 |
| Telbivudine or Tenofovir Treatment in HBeAg-negative Chronic Hepatitis B Patients Based on the Roadmap Concept telbivudine, tenofovir disoproxil fumarate - Chronic Hepatitis B | Phase 4 | Completed | Novartis Pharmaceuticals | 241 | 2011-03-21 | 2018-11-05 |
| An Open Study to Evaluate the Efficacy, Safety of Clevudine Monotherapy or Adefovir and Clevudine Combination in Patients With Chronic Hepatitis B Clevudine 30mg, Clevudine 20mg+Adefovir dipivoxil 10mg, Clevudine 20mg - Chronic Hepatitis B | Phase 4 | Completed | Bukwang Pharmaceutical | 60 | 2010-03-01 | 2014-12-18 |
| A Control Study to Evaluate The Efficacy And Safety of Ozone-therapy in Chronic Hepatitis B medical ozone therapy with humares, conventional interferon-α - Chronic Hepatitis B | Phase 4 | Completed | Nanfang Hospital, Southern Medical University | 439 | 2010-03-01 | 2013-06-26 |
| Adefovir and Lamivudine for Entecavir Resistance (ALTER Study) ADEFOVIR, LAMIVUDINE - Chronic Hepatitis B | Phase 4 | Completed | Korea University | 20 | 2010-02-01 | 2014-02-17 |
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Hepatitis B, Chronic (42) · Hepatitis B (7) · DNA Virus Infections (1) · Fibrosis (1) · HIV Seropositivity (1) · Hepatitis (1) · Hepatitis, Chronic (1) · Pregnancy Complications (1)
Blood-Borne Infections (42) · Chronic Disease (42) · Communicable Diseases (42) · Digestive System Diseases (42) · Disease Attributes (42) · Hepadnaviridae Infections (42) · Hepatitis, Viral, Human (42) · Infections (42) · Liver Diseases (42) · Pathologic Processes (42) · Pathological Conditions, Signs and Symptoms (42) · Virus Diseases (42) · DNA Virus Infections (41) · Hepatitis (41) · Hepatitis, Chronic (41)
Tenofovir (14) · adefovir dipivoxil (9) · Lamivudine (8) · entecavir (8) · peginterferon alfa-2a (6) · adefovir (5) · Telbivudine (4) · clevudine (3) · tenofovir alafenamide (2) · Engerix-B (1) · Thymalfasin (1) · Vitamin D (1) · lipoarabinomannan (1) · peginterferon alfa-2b (1)
Foundation for Liver Research (4) · GlaxoSmithKline (4) · Bukwang Pharmaceutical (3) · Gilead Sciences (3) · Korea University (3) · Novartis Pharmaceuticals (3) · Chinese University of Hong Kong (2) · Samjin Pharmaceutical Co., Ltd. (2) · Southeast University, China (2) · Beijing YouAn Hospital (1) · Bristol-Myers Squibb (1) · Chang Gung Memorial Hospital (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Chong Kun Dang Pharmaceutical (1) · E-DA Hospital (1)
South Korea (17) · China (14) · Netherlands (5) · Taiwan (4) · Germany (3) · Hong Kong (3) · Singapore (3) · Turkey (Türkiye) (3) · Canada (2) · Greece (2) · Italy (2) · Poland (2) · Romania (2) · Spain (2) · United States (2)
Hyung Joon Yim, M.D. (2) · Belinda Jump (1) · Byoung Kuk Jang, M.D (1) · Calvin Pan, MD (1) · Chang Don Lee (1) · Chang Wook Kim, M.D (1) · Choong Kee Park, M.D (1) · Dar-In Tai, MD, PhD (1) · Eileen Yoon (1)
PMID 30689258, PMID 35599306, PMID 15014185, PMID 15470215, PMID 16391218, PMID 16530509, PMID 16673294, PMID 17239478, PMID 17935165, PMID 19092267, PMID 19187608, PMID 19207973, PMID 19469708, PMID 19669255, PMID 19714720, PMID 19729084, PMID 20037275, PMID 20049753, PMID 21182232, PMID 21332542, PMID 21374657, PMID 22343511, PMID 22436845, PMID 23046671, PMID 23518903, PMID 23744454, PMID 24133668, PMID 24183313, PMID 24594870, PMID 24833635, PMID 24915612, PMID 25187919, PMID 25348661, PMID 25596179, PMID 25800784, PMID 25987775, PMID 26143444, PMID 26453773, PMID 26604649, PMID 28329061, PMID 28345157, PMID 28404091, PMID 28404092, PMID 28736139, PMID 29329305, PMID 33524314, PMID 33895361, PMID 33962041, PMID 35941076, PMID 36246814