10 completed, 3 not yet recruiting, 3 unknown, 2 recruiting. 10 Not applicable, 5 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 6, Unknown 2, Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 5 | Completed 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Chlorhexidine: new trials by email Literature Review of Chlorhexidine trials Research Report on Chlorhexidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Chlorhexidine on Human Gingival Fibroblasts HGF, Fibroblast | Not yet recruiting | IRCCS San Raffaele | 3 | 2026-07-01 | 2026-06-25 | |
| ORAL-PROTECT I: Oral Asepsis Preventing Transmission During Intubation Preoperative oral decontamination with chlorhexidine - Bacterial Transmission, Intubation Intratracheal | Not applicable | Not yet recruiting | University Hospital Ulm | 60 | 2026-06-20 | 2026-06-25 |
| Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth Resveratrol-Based Mouthwash, Chlorhexidine Gluconate 0.12 % Mouthwash, Placebo mouthwash - Mouthwash, Chlorhexidine | Phase 3 | Not yet recruiting | University of Baghdad | 20 | 2026-03-01 | 2026-02-06 |
| Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery Intraoperative area irrigation - Colorectal Cancer, Surgical Site Infection | Not applicable | Recruiting | Nanchong Central Hospital | 532 | 2024-07-02 | 2026-03-31 |
| Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients Mouthwash containing 0.12% CHX (Chlorhexidine), Mouthwash containing 0.05% CHX (Chlorhexidine) and 0.05% CPC (Cetylpyridinium Chloride) - Chlorhexidine, Gingivitis | Not applicable | Completed | University of Siena | 72 | 2024-05-20 | 2025-11-24 |
| Effect of Toothbrushing Without Chlorhexidine on Oral Hygiene Indices in Patients With Orotracheal Intubation Oral care - Oral Hygiene, Intensive Care | Not applicable | Completed | Hospital Israelita Albert Einstein | 70 | 2024-03-15 | 2026-09-17 |
| Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis Non surgical periodontal therapy - Periodontitis, Hyaluronic Acid | Not applicable | Unknown | University of Sharjah | 20 | 2022-10-01 | 2023-01-12 |
| Dressing Impregnated With Chlorhexidine and Vancomycin for the Prophylaxis of Central Venous Catheter-related Infections - a Randomized Trial Chlorhexidine - Chlorhexidine | Phase 3 | Completed | Hospital Universitario Evangelico de Curitiba | 516 | 2022-06-01 | 2025-06-03 |
| Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use 0.06% Chlorhexidine Digluconate Toothpaste - Antimicrobial Resistance (AMR), Oral Microbiota | Not applicable | Completed | Masaryk University | 11 | 2022-04-11 | 2026-05-06 |
| The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of Periodontitis active chlorhexidine and placebo probiotic, placebo chlorhexidine and active probiotic, active chlorhexidine and active probiotic - Periodontitis, Chlorhexidine | Not applicable | Completed | Cukurova University | 90 | 2022-04-01 | 2025-06-15 |
| Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining chlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash, Chlorhexidine/ cetylpyridinium chloride, Placebo - Mouthwashes, Chlorhexidine | Phase 3 | Completed | Dental School | 81 | 2022-01-15 | 2026-04-08 |
| Chlorhexidine Bathing to Prevent Hospital-acquired Infections: the CLEANS Study 2% Chlorhexidine bathing - Chlorhexidine, Hospital-Acquired Infection | Not applicable | Unknown | Shanghai Zhongshan Hospital | 247 | 2021-12-01 | 2021-12-29 |
| Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery Chlorhexidine mouthwash, Oxygen - Infection, Pneumonia | Phase 3 | Recruiting | University of Birmingham | 12942 | 2020-11-13 | 2025-02-19 |
| Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0% Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12% - Chlorhexidine, Ventilator Associated Pneumonia | Phase 3 | Unknown | Universidad de Guanajuato | 74 | 2019-02-01 | 2019-03-11 |
| Detection of Chlorhexidine in Tracheal Secretions After Routine Oral Care With Chlorhexidine Gluconate Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD - Chlorhexidine, Intensive Care | Not applicable | Completed | Centre Hospitalier Departemental Vendee | 66 | 2015-11-04 | 2019-02-26 |
| Effectiveness of a Chlorine Dioxide Spray on Dental Plaque and Respiratory Pathogens in Institutionalized Elders Oral spray (chlorhexidine spray, chlorine dioxide spray, sterile water spray) - Oral Hygiene, Frail Elderly | Phase 4 | Completed | The University of Hong Kong | 228 | 2014-06-01 | 2018-05-23 |
| Microbial and Pharmacological Assessment of Chlorhexidine Oropharynx Abnormality, Pneumonia, Ventilator-Associated | Completed | Hôpital Louis Mourier | 30 | 2014-01-27 | 2017-09-25 | |
| Waterless Hand Cleansing With Chlorhexidine During the Perinatal Period Hand cleansing with chlorhexidine, Mother and neonatal health counselling - Hand Washing Behavior, Hand Cleansing Behavior | Not applicable | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 300 | 2013-10-01 | 2017-09-01 |
Periodontitis (3) · Communicable Diseases (2) · Pneumonia, Ventilator-Associated (2) · Surgical Wound Infection (2) · Bacterial Infections (1) · Colorectal Neoplasms (1) · Cross Infection (1) · Dental Plaque (1) · Gingivitis (1) · Health Behavior (1) · Infections (1) · Pathologic Processes (1) · Periodontal Diseases (1) · Pneumonia (1) · Postoperative Complications (1)
Infections (6) · Pathological Conditions, Signs and Symptoms (6) · Disease Attributes (5) · Pathologic Processes (5) · Mouth Diseases (4) · Stomatognathic Diseases (4) · Iatrogenic Disease (3) · Lung Diseases (3) · Periodontal Diseases (3) · Respiratory Tract Diseases (3) · Respiratory Tract Infections (3) · Cross Infection (2) · Healthcare-Associated Pneumonia (2) · Pneumonia (2) · Bacterial Infections and Mycoses (1)
Chlorhexidine (3) · Cetylpyridinium (1) · Dental Care Team (1) · Mouthwashes (1) · Oral Sprays (1) · Oxygen (1) · chlorhexidine gluconate (1)
Centre Hospitalier Departemental Vendee (1) · Cukurova University (1) · Dental School (1) · Hospital Israelita Albert Einstein (1) · Hospital Universitario Evangelico de Curitiba (1) · Hôpital Louis Mourier (1) · IRCCS San Raffaele (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Masaryk University (1) · Nanchong Central Hospital (1) · Shanghai Zhongshan Hospital (1) · The University of Hong Kong (1) · Universidad de Guanajuato (1) · University Hospital Ulm (1) · University of Baghdad (1)
Brazil (3) · China (2) · Mexico (2) · Bangladesh (1) · Czechia (1) · France (1) · Germany (1) · Greece (1) · India (1) · Iraq (1) · Italy (1) · Nigeria (1) · South Africa (1) · Turkey (Türkiye) (1) · United Arab Emirates (1)
Bertrand Diquet, Ph.D (1) · Fernanda de P Eduardo (1) · Jean-Damien Ricard, MD, PhD (1) · Jose A Alvarez, PhD (1) · Nicola Discepoli, DDS MSc PhD (1) · Rupert Pearse (1)