5 completed, 2 terminated, 1 withdrawn. 7 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 5, Terminated 2 |
| Not applicable | 1 | Withdrawn 1 |
Follow Childhood Ependymoblastoma: new trials by email Literature Review of Childhood Ependymoblastoma trials Research Report on Childhood Ependymoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors palbociclib isethionate, pharmacological study, laboratory biomarker analysis - Childhood Choroid Plexus Tumor, Childhood Ependymoblastoma | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 35 | 2014-12-08 | 2021-03-02 |
| Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors gallium Ga 68-edotreotide, positron emission tomography, computed tomography - Acoustic Schwannoma, Adult Anaplastic Astrocytoma | Not applicable | Withdrawn | Sue O'Dorisio | 2013-09-01 | 2017-04-28 | |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors veliparib, temozolomide, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 31 | 2009-07-01 | 2014-07-09 |
| Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors lenalidomide, perfusion-weighted magnetic resonance imaging, diffusion-weighted magnetic resonance imaging - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2004-11-01 | 2013-09-30 |
| Cilengitide in Treating Children With Refractory Primary Brain Tumors cilengitide, laboratory biomarker analysis - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-09-30 |
| Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors O6-benzylguanine, temozolomide, filgrastim - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2002-10-01 | 2013-09-30 |
Astrocytoma (8) · Choroid Plexus Neoplasms (8) · Medulloblastoma (8) · Oligodendroglioma (8) · Familial ependymoma (7) · Optic Nerve Glioma (7) · Rhabdoid Tumor (4) · Spinal Cord Neoplasms (3) · Glioblastoma (2) · Neoplasms, Neuroepithelial (2) · Adenoma, Acidophil (1) · Adenoma, Basophil (1) · Adenoma, Chromophobe (1) · Brain Neoplasms (1) · Burkitt Lymphoma (1)
Brain Diseases (8) · Central Nervous System Diseases (8) · Central Nervous System Neoplasms (8) · Cerebral Ventricle Neoplasms (8) · Neoplasms (8) · Neoplasms by Histologic Type (8) · Neoplasms by Site (8) · Neoplasms, Germ Cell and Embryonal (8) · Neoplasms, Glandular and Epithelial (8) · Neoplasms, Nerve Tissue (8) · Nervous System Diseases (8) · Nervous System Neoplasms (8) · Neuroectodermal Tumors (8) · Brain Neoplasms (7) · Cranial Nerve Diseases (7)
Temozolomide (3) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Calcium Dobesilate (1) · Cilengitide (1) · Dexamethasone (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Lenalidomide (1) · Magnetic Resonance Spectroscopy (1) · O(6)-benzylguanine (1) · Vorinostat (1) · gallium Ga 68 dotatate (1) · palbociclib (1) · veliparib (1)
National Cancer Institute (NCI) (6) · Pediatric Brain Tumor Consortium (1) · Sue O'Dorisio (1)
United States (8) · Canada (2)
Amar Gajjar (1) · David Van Mater, MD (1) · Jack Su (1) · Katherine Warren (1) · M. Sue O'Dorisio, MD, PhD (1) · Najat Daw (1) · Tobey MacDonald (1) · Trent Hummel (1)
U01CA081457 (5), U01CA097452 (2), P30CA086862 (1)