8 completed, 2 terminated. 10 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 8, Terminated 2 |
Follow Childhood Choroid Plexus Tumor: new trials by email Literature Review of Childhood Choroid Plexus Tumor trials Research Report on Childhood Choroid Plexus Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors palbociclib isethionate, pharmacological study, laboratory biomarker analysis - Childhood Choroid Plexus Tumor, Childhood Ependymoblastoma | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 35 | 2014-12-08 | 2021-03-02 |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors veliparib, temozolomide, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 31 | 2009-07-01 | 2014-07-09 |
| Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma ispinesib, laboratory biomarker analysis, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2006-06-01 | 2013-01-16 |
| Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors lenalidomide, perfusion-weighted magnetic resonance imaging, diffusion-weighted magnetic resonance imaging - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2004-11-01 | 2013-09-30 |
| Cilengitide in Treating Children With Refractory Primary Brain Tumors cilengitide, laboratory biomarker analysis - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-09-30 |
| Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors O6-benzylguanine, temozolomide, filgrastim - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2002-10-01 | 2013-09-30 |
| FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia romidepsin - Blastic Phase Chronic Myelogenous Leukemia, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2002-09-01 | 2013-01-16 |
Astrocytoma (10) · Choroid Plexus Neoplasms (10) · Medulloblastoma (10) · Familial ependymoma (9) · Optic Nerve Glioma (9) · Oligodendroglioma (8) · Spinal Cord Neoplasms (5) · Rhabdoid Tumor (4) · Burkitt Lymphoma (3) · Dendritic Cell Sarcoma, Interdigitating (3) · Lymphoma, Large-Cell, Anaplastic (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Recurrence (2) · Adenoma, Acidophil (1) · Adenoma, Basophil (1)
Brain Diseases (10) · Brain Neoplasms (10) · Central Nervous System Diseases (10) · Central Nervous System Neoplasms (10) · Cerebral Ventricle Neoplasms (10) · Glioma (10) · Neoplasms (10) · Neoplasms by Histologic Type (10) · Neoplasms by Site (10) · Neoplasms, Germ Cell and Embryonal (10) · Neoplasms, Glandular and Epithelial (10) · Neoplasms, Nerve Tissue (10) · Nervous System Diseases (10) · Nervous System Neoplasms (10) · Neuroectodermal Tumors (10)
Temozolomide (3) · Vorinostat (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Bortezomib (1) · CK0238273 (1) · Calcium Dobesilate (1) · Cilengitide (1) · Dexamethasone (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Lenalidomide (1) · O(6)-benzylguanine (1) · ispinesib (1) · palbociclib (1) · romidepsin (1)
National Cancer Institute (NCI) (9) · Pediatric Brain Tumor Consortium (1)
United States (10) · Canada (2)
Amar Gajjar (1) · David Van Mater, MD (1) · Jack Su (1) · Jodi Muscal (1) · Katherine Warren (1) · Maryam Fouladi (1) · Najat Daw (1) · Richard Sills (1) · Tobey MacDonald (1) · Trent Hummel (1)
U01CA081457 (5), U01CA097452 (5)