19 completed. 19 Phase 2, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 19 |
| Phase 1 | 5 | Completed 5 |
Follow Bronchiectasis: new trials by email Literature Review of Bronchiectasis trials Research Report on Bronchiectasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial the COMBO Endoscopy Oropharyngeal Airway - Pulmonary Infection, Pulmonary Nodule | Phase 2 | Completed | Zhejiang University | 104 | 2025-06-23 | 2026-02-24 |
| A Study to Test How Well BI 1291583 is Tolerated by People With Cystic Fibrosis Bronchiectasis (Clairafly™) BI 1291583, Placebo to BI 1291583 - Cystic Fibrosis, Bronchiectasis | Phase 2 | Completed | Boehringer Ingelheim | 22 | 2024-04-05 | 2026-06-23 |
| A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis Itepekimab (SAR440340), Placebo - Bronchiectasis | Phase 2 | Completed | Sanofi | 314 | 2024-02-20 | 2026-10-07 |
| A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis CHF6333, CHF6333 Placebo - Bronchiectasis | Phase 1 / Phase 2 | Completed | Chiesi Farmaceutici S.p.A. | 108 | 2023-11-29 | 2026-10-26 |
| Phase 2a, 28-day Investigational Use Study of ARINA-1 in Non-Cystic Fibrosis Bronchiectasis (NCFBE) With Excess Mucus and Cough ARINA-1, Placebo - Non-cystic Fibrosis Bronchiectasis | Phase 2 | Completed | Renovion, Inc. | 40 | 2022-10-03 | 2025-07-23 |
| A Study to Test Whether Different Doses of BI 1291583 Help People With Bronchiectasis BI 1291583, Placebo - Bronchiectasis | Phase 2 | Completed | Boehringer Ingelheim | 322 | 2022-04-28 | 2026-07-28 |
| Bacille Calmette-Guerin (BCG) Vaccine for Immune Protection Against Infections BCG TICE Vaccine - Cystic Fibrosis, Bronchiectasis Adult | Phase 2 | Completed | Johns Hopkins University | 30 | 2021-04-28 | 2025-02-10 |
| Autologous Transplantation of Bronchial Basal Cells for Treatment of Bronchiectasis Bronchial basal cells (BBCs), Bronchoscopic airway clearance treatment （B-ACT） - Bronchiectasis | Phase 1 / Phase 2 | Completed | Ruijin Hospital | 37 | 2020-06-21 | 2023-12-05 |
| Assessment of INS1007 in Participants With Non-Cystic Fibrosis Bronchiectasis Brensocatib 10 mg, Brensocatib 25 mg, Placebo - Non-Cystic Fibrosis Bronchiectasis | Phase 2 | Completed | Insmed Incorporated | 256 | 2017-10-31 | 2023-03-27 |
| Dose-finding Study to Assess the Efficacy, Safety and Tolerability of Tobramycin Inhalation Powder in Patients With Non-Cystic Fibrosis Bronchiectasis and Pulmonary P. Aeruginosa Infection TIP, TIP and placebo, Placebo - Non-cystic Fibrosis Bronchiectasis | Phase 2 | Completed | Novartis Pharmaceuticals | 107 | 2017-02-08 | 2020-08-25 |
| Pharmacokinetic Evaluation and Tolerability of Dry Powder Tobramycin by a Novel Device in Patients With Non Cystic Fibrosis Bronchiectasis Tobramycin - Bronchiectasis | Phase 1 / Phase 2 | Completed | University Medical Center Groningen | 8 | 2013-10-01 | 2014-12-16 |
| Safety and Efficacy of Oral BAY85-8501 in Patients With Non-CF (Cystic Fibrosis) Bronchiectasis BAY85-8501, Placebo - Bronchiectasis | Phase 2 | Completed | Bayer | 94 | 2013-04-01 | 2015-07-09 |
| Evaluation of the Effect of AZD5069 in Patients With Bronchiectasis AZD5069, Placebo - Bronchiectasis, Lung Disease | Phase 2 | Completed | AstraZeneca | 83 | 2011-02-01 | 2015-10-08 |
| Evaluation of Cipro Inhale in Patients With Non-cystic Fibrosis Bronchiectasis Ciprofloxacin (Cipro, BAYQ3939), Placebo - Bronchiectasis | Phase 2 | Completed | Bayer | 124 | 2009-06-01 | 2014-12-12 |
| High Dose Inhaled Mannitol Study mannitol - Bronchiectasis | Phase 1 / Phase 2 | Completed | Syntara | 10 | 2009-01-01 | 2010-02-26 |
| Evaluation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B) in Patients With Bronchiectasis AZLI - Bronchiectasis | Phase 2 | Completed | Gilead Sciences | 89 | 2008-12-01 | 2014-03-20 |
| A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis AZD9668, Placebo - Bronchiectasis | Phase 2 | Completed | AstraZeneca | 38 | 2008-09-01 | 2012-08-20 |
| A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device dry powder inhaled mannitol - Healthy, Bronchiectasis | Phase 1 / Phase 2 | Completed | Syntara | 15 | 2008-08-01 | 2009-09-18 |
| Safety and Tolerability Study of 2 Dose Level of Arikayce™ in Patients With Bronchiectasis and Chronic Infection Due to Pseudomonas Aeruginosa. 280 mg Arikayce™, Matching Placebo for Cohort 1, 560 mg Arikayce™ - Bronchiectasis | Phase 2 | Completed | Insmed Incorporated | 64 | 2008-06-24 | 2019-07-10 |
Cystic Fibrosis (2) · Lung Diseases (2) · Respiratory Tract Diseases (2) · Hypoxia (1) · Pseudomonas Infections (1) · Respiration Disorders (1) · Respiratory Tract Infections (1)
Bronchial Diseases (19) · Respiratory Tract Diseases (17) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Digestive System Diseases (2) · Genetic Diseases, Inborn (2) · Infant, Newborn, Diseases (2) · Lung Diseases (2) · Pancreatic Diseases (2) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Gram-Negative Bacterial Infections (1) · Infections (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1) · Signs and Symptoms, Respiratory (1)
Aztreonam (1) · Ciprofloxacin (1) · Inhalation (1) · Lysine Acetyltransferase 5 (1) · Mannitol (1) · N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide (1) · N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide (1) · Tobramycin (1) · brensocatib (1) · itepekimab (1)
AstraZeneca (2) · Bayer (2) · Boehringer Ingelheim (2) · Insmed Incorporated (2) · Syntara (2) · Chiesi Farmaceutici S.p.A. (1) · Gilead Sciences (1) · Johns Hopkins University (1) · Novartis Pharmaceuticals (1) · Renovion, Inc. (1) · Ruijin Hospital (1) · Sanofi (1) · University Medical Center Groningen (1) · Zhejiang University (1)
United Kingdom (10) · United States (9) · Germany (7) · Spain (7) · Italy (6) · Australia (5) · France (5) · Netherlands (5) · Poland (5) · Belgium (4) · Bulgaria (3) · Canada (3) · China (3) · Czechia (3) · Denmark (3)
Bengt Larsson,, M.B (1) · Carin Jorup (1) · Carlos Fernandez, MD (1) · Charles L Daley, MD (1) · Gina Eagle, MD (1) · Huib Kerstjens, MD, PhD (1) · James D. Chalmers (1) · Noah Lecthzin, MD, MHS (1) · Steve Lamola, MD (1) · Yun Feng, M.D., Ph.D (1)
PMID 39175217, PMID 23018904, PMID 23433769, PMID 24626872, PMID 31433997, PMID 32855225, PMID 32897034, PMID 37198686, PMID 37538173, PMID 39255990, PMID 39566467, PMID 39938076
2009 (1), 2015 (1), 2017 (1), 2023 (1)