94 completed, 81 unknown, 74 recruiting, 36 terminated. 145 Phase 2, 84 Not applicable, 61 Phase 1, 26 Phase 3, 9 Early Phase 1.
Follow Brain Metastases: new trials by email Literature Review of Brain Metastases trials Research Report on Brain Metastases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| ctDNA-Guided Intraventricular Therapy for CNS Malignancies CSF ctDNA-Guided Clinical Management - Leptomeningeal Disease, Glioblastoma | Not applicable | Not yet recruiting | Alireza Mansouri | 77 | 2027-01-01 | 2026-07-08 |
| IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, CD70 IHC assay - Brain Metastases | Phase 1 | Recruiting | University of Florida | 12 | 2026-10-13 | 2026-10-16 |
| Preoperative Embolization for Highly Vascular Brain Tumors Preoperative Endovascular Embolization - Brain Neoplasms, Meningioma | Not applicable | Not yet recruiting | Assiut University | 55 | 2026-10-01 | 2026-09-17 |
| University of Kentucky Markey Cancer Center Neuro-Oncology Multi-Disciplinary Tumor Board Protocol for the Treatment of Advanced Brain Metastases Neuro-Oncology Multi-Disciplinary Tumor Board Review - Brain Metastases | Not applicable | Not yet recruiting | John L. Villano, MD, PhD | 125 | 2026-09-01 | 2026-08-25 |
| MeDex: No Perioperative Dexamethasone in Brain Metastases Withholding perioperative Dexamethasone - Brain Metastases | Not applicable | Recruiting | University of Louisville | 35 | 2026-08-01 | 2026-05-29 |
| Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial) MA-WBRT (Memory Avoidance Whole Brain Radiation Therapy (MA-WBRT)), HA-WBRT (Hippocampal Avoidance Whole Brain Radiation Therapy (HA-WBRT)), Memantine - Brain Metastases | Phase 2 | Recruiting | Case Comprehensive Cancer Center | 90 | 2026-07-09 | 2026-09-22 |
| Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy SV-BR-1-GM Vaccine, Cyclophosphamide, Pembrolizumab - Brain Metastases, Leptomeningeal Metastasis | Phase 1 | Withdrawn | Medical College of Wisconsin | 2026-06-15 | 2026-06-17 | |
| Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases Dalpiciclib, Endocrine Therapy of Physician's Choice, Brain Radiotherapy - Breast Cancer, Brain Metastases | Phase 2 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 46 | 2026-06-01 | 2026-04-30 |
| Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy. CT scan - Short Time Examination, Brain Metastases | Recruiting | Centre Hospitalier Universitaire, Amiens | 50 | 2026-05-18 | 2026-06-08 | |
| Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1 [C-11]-CS1P1, Brain MRI - Central Nervous System Cancer, Brain Metastases | Phase 2 | Recruiting | Washington University School of Medicine | 104 | 2026-04-16 | 2026-04-21 |
| Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers HER2 Testing, MSI Testing, PD-L1 Testing - Gastric Cancer, Esophageal Cancer | Recruiting | Blokhin's Russian Cancer Research Center | 30 | 2026-04-01 | 2026-10-05 | |
| Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases FSRT, HA-WBRT-SIB, Bevacizumab - Lung Adenocarcinoma, Brain Metastases | Phase 3 | Recruiting | Sun Yat-sen University | 220 | 2026-03-20 | 2026-04-06 |
| Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT) Staged Stereotactic Radiosurgery (SSRS), Fractionated Stereotactic Radiotherapy (FSRT) - Brain Metastases, Cancer (With CNS Involvement) | Phase 2 | Recruiting | Medical University of South Carolina | 54 | 2026-02-06 | 2026-09-18 |
| Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer Neurosurgical Resection (NRS): En-bloc (EBR), Total piecemeal (TPR), Subtotal (SPR) or Partial (PPR), Radiotherapy (RT): Stereotactic Radiosurgery/Radiotherapy (SRS/SRT), Whole-Brain Radiotherapy (WBRT), Combined Local Treatment Modalities - Gastric Cancer, Esophageal Cancer | Active not recruiting | Blokhin's Russian Cancer Research Center | 230 | 2026-02-01 | 2026-03-04 | |
| Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases Cognitive Stepped Care Program (CSCP) - Brain Metastases, Brain Metastasis | Not applicable | Recruiting | University Health Network, Toronto | 140 | 2026-01-09 | 2026-01-21 |
| Furmonertinib 160mg vs 80mg + Chemotherapy in EGFR-Mutated NSCLC With Brain Metastases: Efficacy and Safety Study Furmonertinib, carboplatin, pemetrexed - Non-small Cell Lung Cancer (NSCLC), Brain Metastases | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 60 | 2026-01-01 | 2026-01-26 |
| Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM) Surgery, LITT - Brain Metastases | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 155 | 2026-01-01 | 2026-09-18 |
| Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis Non-Small Cell Lung Cancer, Brain Metastases | Enrolling by invitation | Ming Yang | 380 | 2025-11-01 | 2026-01-29 | |
| 7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI) 7t MRI - Small-cell Lung Cancer, Brain Metastases | Recruiting | University of Missouri-Columbia | 20 | 2025-11-01 | 2025-12-02 |
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Brain Neoplasms (347) · Carcinoma, Non-Small-Cell Lung (56) · Breast Neoplasms (43) · Lung Neoplasms (29) · Melanoma (27) · Neoplasm Metastasis (19) · Meningeal Carcinomatosis (16) · Glioma (15) · Neoplasms (15) · Glioblastoma (11) · Meningioma (9) · Small Cell Lung Carcinoma (8) · Triple Negative Breast Neoplasms (6) · Carcinoma, Renal Cell (5) · Central Nervous System Neoplasms (5)
Nervous System Diseases (346) · Nervous System Neoplasms (346) · Central Nervous System Diseases (345) · Neoplasms by Site (345) · Brain Diseases (343) · Central Nervous System Neoplasms (342) · Neoplasms (332) · Respiratory Tract Neoplasms (84) · Thoracic Neoplasms (84) · Lung Diseases (82) · Respiratory Tract Diseases (81) · Bronchial Neoplasms (63) · Carcinoma, Bronchogenic (63) · Skin Diseases (63) · Skin and Connective Tissue Diseases (63)
Radiosurgery (44) · Radiotherapy (14) · pembrolizumab (12) · Bevacizumab (11) · Temozolomide (10) · Trastuzumab (10) · Ipilimumab (9) · Pemetrexed (9) · Carboplatin (8) · Nivolumab (7) · Magnetic Resonance Imaging (6) · Spermine Synthase (6) · fluciclovine F-18 (6) · Erlotinib Hydrochloride (5) · Surgical Procedures, Operative (5)
Sun Yat-sen University (14) · University Health Network, Toronto (10) · M.D. Anderson Cancer Center (9) · Fudan University (8) · Memorial Sloan Kettering Cancer Center (7) · Baptist Health South Florida (6) · Chinese Academy of Medical Sciences (6) · H. Lee Moffitt Cancer Center and Research Institute (6) · Betta Pharmaceuticals Co., Ltd. (5) · University of Alabama at Birmingham (5) · Angiochem Inc (3) · Assistance Publique - Hôpitaux de Paris (3) · Assistance Publique Hopitaux De Marseille (3) · Brigham and Women's Hospital (3) · British Columbia Cancer Agency (3)
United States (136) · China (74) · France (25) · Canada (24) · Germany (15) · Italy (11) · Taiwan (10) · Australia (7) · Belgium (7) · Netherlands (7) · Spain (7) · Austria (6) · South Korea (6) · United Kingdom (6) · Denmark (5)
Caroline Chung, MD (4) · Jianping Xiao (3) · Alexey Tryakin, MD, PhD, professor (2) · Ali Bekyashev, MD, PhD, professor (2) · Betty Lawrence (2) · Harriet Kluger, MD (2) · Igor J Barani, MD (2) · Jeffrey Clarke, MD (2) · Jianping Xiao, Dr (2) · Lance Hall, MD (2) · Likun Chen (2) · Nancy Lin, MD (2) · Yuankai Shi, MD (2) · Aaron Allen, M.D. (1) · Adam Dicker, MD, PhD (1)
PMID 16757720, PMID 19801201, PMID 34081125, PMID 25349290, PMID 27458945, PMID 35096584, PMID 11452123, PMID 12750523, PMID 14701778, PMID 15254054, PMID 16525186, PMID 16856022, PMID 17229875, PMID 17446005, PMID 17674975, PMID 17869672, PMID 20392503, PMID 20598457, PMID 21041710, PMID 21467949, PMID 21472002, PMID 21584645, PMID 22012633, PMID 22134072, PMID 22362813, PMID 22584333, PMID 23129122, PMID 23420398, PMID 23814264, PMID 24021541, PMID 24133369, PMID 24419416, PMID 24985049, PMID 25614945, PMID 25928457, PMID 26148750, PMID 26654128, PMID 26674923, PMID 26678660, PMID 26823294, PMID 2725874, PMID 27306442, PMID 27343440, PMID 27392066, PMID 27412562, PMID 27659537, PMID 28126333, PMID 28273722, PMID 28275886, PMID 28913154
2018 (3), 2009 (2), 2019 (2), 2008 (1), 2014 (1), 2015 (1), 2017 (1), 2023 (1), 2025 (1), P30CA012197 (1), P30CA014089 (1), P30CA046934 (1), R01CA158800 (1), R33CA225400 (1), R44CA261240 (1)