75 completed, 17 terminated, 12 recruiting, 11 active not recruiting. 127 Phase 2, 26 Phase 1, 3 Phase 3.
Follow Bone Marrow Neoplasms: new trials by email Literature Review of Bone Marrow Neoplasms trials Research Report on Bone Marrow Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Rusfertide in Adults With Polycythemia Vera in China Rusfertide - Polycythemia Vera | Phase 2 | Not yet recruiting | Takeda | 24 | 2027-03-01 | 2026-08-28 |
| Phase 2 Study of Oral Epetraborole in Adults With Polycythemia Vera Epetraborole, Placebo - Polycythemia Vera (SNOMED CT: 109992005) | Phase 2 | Not yet recruiting | AN2 Therapeutics, Inc | 75 | 2026-11-01 | 2026-10-23 |
| A Study to Investigate AG-236 in Subjects ≥18 Years of Age With Polycythemia Vera AG-236, Placebo - Polycythemia Vera | Phase 2 / Phase 3 | Not yet recruiting | Agios Pharmaceuticals, Inc. | 245 | 2026-11-01 | 2026-10-13 |
| A Study of Ropeg-Interferon in People With Polycythemia Vera Ropeginterferon - Polycythemia Vera (PV), JAK2 Mutation | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 55 | 2026-10-30 | 2026-11-03 |
| A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025). Bomedemstat, Ruxolitinib, Ropeginterferon alfa-2b - Polycythemia Vera | Phase 2 / Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 380 | 2026-10-29 | 2026-11-05 |
| A Study of Rusfertide in Japanese Adults With Polycythemia Vera Rusfertide - Polycythemia Vera | Phase 2 | Recruiting | Takeda | 9 | 2026-07-14 | 2026-10-02 |
| Phase IIa Study of Flonoltinib Maleate Tablets in the Treatment of Patients With Polycythemia Vera Flonoltinib 75mg, Flonoltinib 100mg, Flonoltinib 125mg - Polycythemia Vera (PV) | Phase 2 | Recruiting | Chengdu Zenitar Biomedical Technology Co., Ltd | 60 | 2025-09-23 | 2026-08-14 |
| A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Accelerated Phase Myeloproliferative Neoplasm, Blast Phase Myeloproliferative Neoplasm | Phase 2 | Recruiting | National Cancer Institute (NCI) | 78 | 2025-08-14 | 2026-10-27 |
| A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV) DISC-3405 - Polycythemia Vera (PV) | Phase 2 | Active not recruiting | Disc Medicine, Inc | 60 | 2025-08-12 | 2026-11-02 |
| MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial Methotrexate (MTX) - Polycythemia Vera (PV), Essential Thrombocythemia (ET) | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 54 | 2024-10-02 | 2025-12-17 |
| Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Clonal Cytopenia of Undetermined Significance, Essential Thrombocythemia | Phase 2 | Recruiting | University of Southern California | 30 | 2024-03-01 | 2026-03-27 |
| A Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Polycythemia Vera (IMG-7289-CTP-203/MK-3543-004) Bomedemstat - Polycythemia Vera | Phase 2 | Completed | Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA) | 20 | 2023-09-07 | 2026-05-07 |
| Pegylated Interferon α-2b in Combination With Ruxolitinib for Treating Hydroxyurea-resistant/Intolerant PV Ruxolitinib, Pegylated interferon α-2b - Polycythemia Vera | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 94 | 2023-06-30 | 2024-07-03 |
| Study to Assess SLN124 in Patients With Polycythemia Vera SLN124, Placebo - Polycythemia Vera | Phase 1 / Phase 2 | Active not recruiting | Silence Therapeutics plc | 69 | 2023-01-26 | 2025-12-19 |
| Ruxolitinib in Thrombocythemia and Polycythemia Vera Ruxolitinib - Essential Thrombocythemia, Polycythemia Vera | Phase 2 | Recruiting | Massachusetts General Hospital | 60 | 2022-03-21 | 2026-01-08 |
| An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms N-Acetylcysteine - Myeloproliferative Neoplasm, MPN | Phase 1 / Phase 2 | Recruiting | University of California, Irvine | 27 | 2022-01-03 | 2026-03-10 |
| A Study to Evaluate Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx) in Patients With Polycythemia Vera sapablursen - Phlebotomy Dependent Polycythemia Vera | Phase 2 | Completed | Ionis Pharmaceuticals, Inc. | 50 | 2021-12-30 | 2026-07-09 |
| Two Step Haplo With Radiation Conditioning Fludarabine, Total-Body Irradiation, Donor Lymphocyte Infusion - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | Thomas Jefferson University | 63 | 2021-10-25 | 2025-10-30 |
| A Study to Access Efficacy and Safety of P1101 in Chinese PV Patients Who Are Intolerant or Resistance to HU Ropeginterferon alfa-2b - Polycythemia Vera | Phase 2 | Active not recruiting | PharmaEssentia | 49 | 2021-10-08 | 2025-08-03 |
| To Assess the Safety, Tolerability and Efficacy of Itacitinib Immediate Release Tablets in Participants With Primary or Secondary Myelofibrosis Who Have Received Prior Ruxolitinib and/or Fedratinib Monotherapy (LIMBER-213) itacitinib - Myelofibrosis, Polycythemia Vera | Phase 2 | Completed | Incyte Corporation | 4 | 2021-07-12 | 2025-09-02 |
Showing 20 of 127. Sign in to see all of them.
Polycythemia Vera (121) · Primary Myelofibrosis (80) · Thrombocythemia, Essential (73) · Myeloproliferative Disorders (60) · Leukemia, Myeloid, Acute (34) · Leukemia, Myelomonocytic, Chronic (33) · Myelodysplastic Syndromes (32) · Leukemia (27) · Leukemia, Lymphocytic, Chronic, B-Cell (27) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (27) · Multiple Myeloma (26) · Lymphoma, Non-Hodgkin (22) · Leukemia, Myeloid, Accelerated Phase (21) · Blast Crisis (20) · Congenital Abnormalities (20)
Hemic and Lymphatic Diseases (126) · Neoplasms by Site (126) · Hematologic Neoplasms (125) · Neoplasms (123) · Bone Marrow Diseases (122) · Hematologic Diseases (119) · Blood Platelet Disorders (77) · Hemorrhagic Disorders (77) · Blood Coagulation Disorders (73) · Thrombocytosis (69) · Myeloproliferative Disorders (61) · Neoplasms by Histologic Type (49) · Pathological Conditions, Signs and Symptoms (46) · Pathologic Processes (45)
fludarabine phosphate (22) · Cyclophosphamide (20) · Peripheral Blood Stem Cell Transplantation (19) · Busulfan (17) · Whole-Body Irradiation (14) · ruxolitinib (14) · Mycophenolic Acid (12) · Tacrolimus (11) · Cyclosporine (10) · Methotrexate (10) · Antilymphocyte Serum (7) · fludarabine (7) · Aspirin (5) · Melphalan (5) · Radiotherapy (5)
M.D. Anderson Cancer Center (15) · Fred Hutchinson Cancer Center (9) · National Cancer Institute (NCI) (6) · Italfarmaco (4) · Mayo Clinic (4) · Ronald Hoffman (4) · H. Lee Moffitt Cancer Center and Research Institute (3) · Roswell Park Cancer Institute (3) · Hoffmann-La Roche (2) · Incyte Corporation (2) · Janssen-Cilag International NV (2) · OHSU Knight Cancer Institute (2) · Protagonist Therapeutics, Inc. (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2)
United States (92) · Germany (14) · Italy (14) · France (10) · United Kingdom (10) · Australia (9) · Canada (9) · Poland (6) · Spain (5) · Denmark (4) · Austria (3) · Belgium (3) · China (3) · Netherlands (3) · Switzerland (3)
Alessandro Rambaldi, MD (4) · Ruben A. Mesa, MD (4) · Jorge Cortes, MD (3) · Ronald Hoffman, MD (3) · Srdan Verstovsek, MD (3) · Ayalew Tefferi, MD (2) · Gabriela Hobbs, MD (2) · H. Joachim Deeg, MD (2) · John Mascarenhas, MD (2) · Teresa Field, MD, PhD (2) · Uday Popat, MD (2)
PMID 32499241, PMID 40313042, PMID 11468154, PMID 16709929, PMID 18650451, PMID 19841031, PMID 20651074, PMID 20843246, PMID 22718840, PMID 23890523, PMID 24362550, PMID 24903629, PMID 25047979, PMID 25261096, PMID 25563429, PMID 25762180, PMID 26088933, PMID 26210442, PMID 26261238, PMID 26332546, PMID 27479177, PMID 28291640, PMID 28622623, PMID 29134664, PMID 29152412, PMID 29544547, PMID 30185431, PMID 30409796, PMID 30630975, PMID 32634234, PMID 32678292, PMID 32732354, PMID 33476571, PMID 33609248, PMID 34424319, PMID 34581778, PMID 34933330, PMID 36564535, PMID 36911725, PMID 37129584, PMID 37165840, PMID 37344895, PMID 37422688, PMID 37592092, PMID 38320126, PMID 38381675, PMID 40775758, PMID 42304430, PMID 42611791, PMID 9326205
P30CA015083 (4), P01CA108671 (3), P01CA015396 (2), P01CA018029 (2), P30CA006973 (2), P30CA015704 (2), P30CA016672 (2), 2008 (1), 2015 (1), 2017 (1), N01CM17104 (1), N01CM62201 (1), P01CA078902 (1), P30CA014089 (1), P30CA014599 (1)