2 completed, 2 unknown, 1 terminated, 1 withdrawn. 5 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Unknown 2, Completed 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 2 | Unknown 2 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET) PEGASYS, Aspirin - High Risk Polycythemia Vera, High Risk Essential Thrombocythemia | Phase 2 | Completed | Ronald Hoffman | 135 | 2011-09-01 | 2017-01-11 |
| Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET) PEGASYS, Hydroxyurea, Aspirin - High Risk Polycythemia Vera, High Risk Essential Thrombocythemia | Phase 3 | Completed | Ronald Hoffman | 168 | 2011-09-01 | 2019-04-30 |
| LBH589 (Panobinostat) for the Treatment of Myelofibrosis LBH589 - Primary Myelofibrosis, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase | Phase 1 / Phase 2 | Unknown | Ronald Hoffman | 22 | 2009-09-01 | 2015-03-06 |
| Clopidogrel and Aspirin for the Treatment of Polycythemia Vera Clopidogrel (Plavix), Placebo, Aspirin - Polycythemia Vera | Phase 2 | Withdrawn | Ronald Hoffman | 2009-06-01 | 2014-11-26 | |
| CEP-701 (Lestaurtinib) in Myelofibrosis CEP-701 (Lestaurtinib) - Myelofibrosis, Essential Thrombocythemia | Phase 1 / Phase 2 | Unknown | Ronald Hoffman | 60 | 2008-04-01 | 2014-11-26 |
| Phase II Study of Bevacizumab (Avastin®) in Myelofibrosis bevacizumab (Avastin) - Myelofibrosis | Phase 2 | Terminated | Ronald Hoffman | 13 | 2008-03-01 | 2014-08-22 |
Polycythemia Vera (5) · Primary Myelofibrosis (3) · Thrombocythemia, Essential (3)
Aspirin (3) · peginterferon alfa-2a (2) · Bevacizumab (1) · Clopidogrel (1) · Hydroxyurea (1) · Panobinostat (1) · lestaurtinib (1)
United States (5) · Italy (2) · France (1) · United Kingdom (1)
John Mascarenhas, MD (2) · Alessandro Rambaldi, MD (1) · Claire Harrison, MD (1) · Ellen Ritchie, MD (1) · Jean-Jacques Kiladjian, MD (1) · Mary Frances McMullin, MD (1) · Ruben Mesa, MD (1)
PMID 40775758, PMID 23812932, PMID 25563429, PMID 31515250, PMID 35007321
P01CA108671 (5)