147 completed, 36 recruiting, 32 terminated, 20 active not recruiting. 120 Phase 2, 71 Phase 1, 35 Phase 3, 24 Not applicable, 3 Early Phase 1.
Follow Polycythemia Vera: new trials by email Literature Review of Polycythemia Vera trials Research Report on Polycythemia Vera
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Rusfertide in Adults With Polycythemia Vera in China Rusfertide - Polycythemia Vera | Phase 2 | Not yet recruiting | Takeda | 24 | 2027-03-01 | 2026-08-28 |
| WELL-MPN: A Digital Lifestyle App for Patients With MPNs WELL-MPN Digital App - Myeloproliferative Neoplasms (MPNs) | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 75 | 2027-01-01 | 2026-09-29 |
| A Study to Better Understand the Diagnosis and Treatment of Polycythaemia Vera No Intervention - Polycythemia Vera | Not yet recruiting | Takeda | 90 | 2026-12-01 | 2026-10-09 | |
| A Study to Investigate AG-236 in Subjects ≥18 Years of Age With Polycythemia Vera AG-236, Placebo - Polycythemia Vera | Phase 2 / Phase 3 | Not yet recruiting | Agios Pharmaceuticals, Inc. | 245 | 2026-11-01 | 2026-10-13 |
| A Study of Ropeg-Interferon in People With Polycythemia Vera Ropeginterferon - Polycythemia Vera (PV), JAK2 Mutation | Phase 2 | Not yet recruiting | Memorial Sloan Kettering Cancer Center | 55 | 2026-10-30 | 2026-10-21 |
| A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025). Bomedemstat, Ruxolitinib, Ropeginterferon alfa-2b - Polycythemia Vera | Phase 2 / Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 380 | 2026-10-21 | 2026-10-21 |
| Standardized Documentation and Assessments for Polycythemia Vera: A Quality Improvement Initiative Standardized progress note - Polycythemia Vera | Not applicable | Not yet recruiting | Massachusetts General Hospital | 32 | 2026-08-05 | 2026-07-29 |
| ENERGIA: Personalized Exercise Program for Fatigue in Patients With Myeloproliferative Neoplasms and Chronic Myeloid Leukemia Participants will take part in a 12-week exercise program that includes aerobic and resistance training, tailored to their individual fitness level and clinical condition. - Myeloproliferative Disease, Polycythemia Vera | Not applicable | Not yet recruiting | Carmen Fava | 25 | 2026-08-01 | 2026-04-09 |
| Efficacy and Safety of Ropeginterferon Alfa 2b (P1101) for Patients With Polycythemia Vera Ropeginterferon alfa-2b, Phlebotomy and aspirin - Polycythemia Vera, Myeloproliferative Neoplasm | Phase 4 | Withdrawn | PharmaEssentia | 2026-08-01 | 2026-07-31 | |
| A Study of Rusfertide in Japanese Adults With Polycythemia Vera Rusfertide - Polycythemia Vera | Phase 2 | Recruiting | Takeda | 9 | 2026-07-14 | 2026-10-02 |
| INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV) Sapablursen, Placebo - Polycythemia Vera | Phase 3 | Recruiting | Ono Pharmaceutical Co., Ltd. | 250 | 2026-05-25 | 2026-10-21 |
| Study of ZE74-0282 for Patients With JAK2 V617F Positive Blood Cancers ZE74-0282 - Polycythemia Vera (PV), Myelofibrosis (MF) | Phase 1 | Not yet recruiting | Eilean Therapeutics | 60 | 2026-05-15 | 2026-04-14 |
| Study of INCA036978 in Participants With Myeloproliferative Neoplasms INCA036978, Standard disease-directed therapy - Myeloproliferative Neoplasms | Phase 1 | Recruiting | Incyte Corporation | 218 | 2026-05-11 | 2026-10-09 |
| A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms PRT12396 - Polycythemia Vera (PV), Myelofibrosis (MF) | Phase 1 | Recruiting | Prelude Therapeutics Incorporated | 100 | 2026-04-29 | 2026-10-01 |
| A Clinical Study of Gecacitinib Combined With Pegylated Interferon in Patients With PV Gecacitinib Hydrochloride Tablets；Pegylated interferon alfa-2b - Polycythemia Vera (PV) | Not applicable | Recruiting | Duan Minghui | 30 | 2026-04-02 | 2026-06-24 |
| Potential Biological and Physiological Determinants for Exercice in Patients With Polycythemia Vera Research samples blood viscosity and viscoelasticity: - Polycythemia, Polycythemia Vera (PV) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 54 | 2026-01-01 | 2026-01-15 |
| A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes Polycythemia Vera, Thrombocythemia | Recruiting | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS | 678 | 2025-12-01 | 2026-07-09 | |
| MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs) Polycythemia Vera, ET (Essential Thrombocythemia) | Recruiting | MPN Research Foundation | 5000 | 2025-09-26 | 2026-01-23 | |
| Phase IIa Study of Flonoltinib Maleate Tablets in the Treatment of Patients With Polycythemia Vera Flonoltinib 75mg, Flonoltinib 100mg, Flonoltinib 125mg - Polycythemia Vera (PV) | Phase 2 | Recruiting | Chengdu Zenitar Biomedical Technology Co., Ltd | 60 | 2025-09-23 | 2026-08-14 |
| A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Accelerated Phase Myeloproliferative Neoplasm, Blast Phase Myeloproliferative Neoplasm | Phase 2 | Recruiting | National Cancer Institute (NCI) | 78 | 2025-08-14 | 2026-09-30 |
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Primary Myelofibrosis (181) · Thrombocythemia, Essential (174) · Myeloproliferative Disorders (144) · Leukemia, Myeloid, Acute (88) · Leukemia, Myelomonocytic, Chronic (85) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (80) · Leukemia, Lymphocytic, Chronic, B-Cell (78) · Myelodysplastic Syndromes (72) · Multiple Myeloma (71) · Leukemia (67) · Lymphoma, Follicular (67) · Lymphoma, Large B-Cell, Diffuse (64) · Lymphoma, Mantle-Cell (64) · Lymphoma, Non-Hodgkin (64)
Hemic and Lymphatic Diseases (276) · Neoplasms by Site (276) · Bone Marrow Neoplasms (275) · Hematologic Neoplasms (272) · Bone Marrow Diseases (266) · Hematologic Diseases (262) · Neoplasms (261) · Blood Platelet Disorders (180) · Hemorrhagic Disorders (176) · Blood Coagulation Disorders (174) · Thrombocytosis (169) · Myeloproliferative Disorders (132) · Pathological Conditions, Signs and Symptoms (112) · Neoplasms by Histologic Type (111) · Pathologic Processes (109)
fludarabine phosphate (29) · ruxolitinib (29) · Peripheral Blood Stem Cell Transplantation (26) · Cyclophosphamide (25) · Busulfan (21) · Tacrolimus (16) · Whole-Body Irradiation (15) · Mycophenolic Acid (14) · Methotrexate (13) · Cyclosporine (12) · Antilymphocyte Serum (11) · Hydroxyurea (11) · Aspirin (9) · Filgrastim (8) · fludarabine (8)
M.D. Anderson Cancer Center (16) · National Cancer Institute (NCI) (13) · Novartis Pharmaceuticals (12) · Fred Hutchinson Cancer Center (11) · Incyte Corporation (6) · FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS (5) · Icahn School of Medicine at Mount Sinai (5) · Italfarmaco (5) · Mayo Clinic (5) · Ronald Hoffman (5) · AOP Orphan Pharmaceuticals AG (4) · City of Hope Medical Center (4) · European Organisation for Research and Treatment of Cancer - EORTC (4) · Memorial Sloan Kettering Cancer Center (4) · Northwestern University (4)
United States (177) · Italy (43) · France (37) · Germany (33) · United Kingdom (27) · Canada (23) · Australia (19) · Belgium (18) · Spain (18) · Poland (14) · Hungary (13) · China (11) · Israel (11) · Japan (10) · Netherlands (10)
Ronald Hoffman, MD (7) · John Mascarenhas, MD (6) · Alessandro Rambaldi, MD (4) · Ruben A. Mesa, MD (4) · Heinz Gisslinger, MD (3) · Jorge Cortes, MD (3) · Srdan Verstovsek, MD (3) · Ayalew Tefferi, MD (2) · Charles A. Linker, MD (2) · Gabriela Hobbs, MD (2)
PMID 29246923, PMID 29396713, PMID 32499241, PMID 33275766, PMID 40313042, PMID 40775758, PMID 41890273, PMID 11373690, PMID 11468154, PMID 15459300, PMID 15570084, PMID 16709929, PMID 17397698, PMID 18650451, PMID 18698002, PMID 19841031, PMID 20651074, PMID 20843246, PMID 22259028, PMID 22480131, PMID 22718840, PMID 23216616, PMID 23358983, PMID 23682558, PMID 23890523, PMID 24362550, PMID 24474568, PMID 24903629, PMID 25047979, PMID 25563429, PMID 25629741, PMID 25762180, PMID 25939704, PMID 26088933, PMID 26113113, PMID 26175532, PMID 26210442, PMID 26261238, PMID 26332546, PMID 26700120, PMID 26700123, PMID 26853648, PMID 27020837, PMID 27102499, PMID 27291777, PMID 27479177, PMID 27916398, PMID 28193568, PMID 28291640, PMID 28482711
P01CA108671 (7), P30CA015083 (5), P30CA006973 (4), 2014 (3), P01CA018029 (3), P30CA015704 (3), P30CA016086 (3), P30CA033572 (3), 2023 (2), P01CA015396 (2), P30CA016672 (2), P30CA060553 (2), P30CA068485 (2), P30CA072720 (2), U01CA062491 (2)