4 completed, 2 recruiting, 1 not yet recruiting, 1 suspended. 9 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 4, Recruiting 2, Not yet recruiting 1, Suspended 1, Unknown 1 |
| Phase 2 | 3 | Completed 1, Not yet recruiting 1, Unknown 1 |
Follow Aortic Dissection: new trials by email Literature Review of Aortic Dissection trials Research Report on Aortic Dissection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection Ketorolac, 0.9 % saline - Aortic Dissection, Inflammation | Phase 3 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 1346 | 2025-10-27 | 2026-08-31 |
| Use of PRP in Open Surgery for Type A Aortic Dissection Autologous Platelet Rich Plasma, Standard Blood Management - Aortic Dissection Type A, Transfusions | Phase 2 / Phase 3 | Not yet recruiting | Beijing Anzhen Hospital | 250 | 2025-06-30 | 2025-06-05 |
| Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome. Enzastaurin, Placebo - Vascular Ehlers-Danlos Syndrome | Phase 3 | Suspended | Aytu BioPharma, Inc. | 260 | 2025-01-01 | 2024-03-08 |
| Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome ACER-002 (celiprolol) 200 mg BID, Placebo BID - Vascular Ehlers-Danlos Syndrome | Phase 3 | Recruiting | Acer Therapeutics Inc. | 150 | 2022-11-07 | 2025-08-24 |
| Strategy for Aortic Surgery Hemostasis TDM-621 - Ascending Aorta Abnormality, Ascending Aortic Dissection | Phase 2 / Phase 3 | Unknown | University of Sao Paulo General Hospital | 200 | 2018-12-04 | 2019-04-17 |
| Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome (ARCADE) Irbesartan, Placebo - Ehlers-Danlos Syndrome, Vascular Type | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 61 | 2016-01-01 | 2024-02-29 |
| Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome Losartan Potassium, Atenolol - Marfan Syndrome | Phase 3 | Completed | Carelon Research | 608 | 2007-01-01 | 2025-03-07 |
| Investigation of Stent-grafts in Aortic Dissection (INSTEAD) endoprosthesis - Aortic Dissection | Phase 2 / Phase 3 | Completed | University of Rostock | 140 | 2002-02-01 | 2011-08-12 |
| To Evaluate the Safety and Efficacy for GORE TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Disease Endovascular Stent-graft repair of descending thoracic aorta - Aneurysm, Dissecting, Aortic Aneurysm, Thoracic | Phase 3 | Completed | Stanford University | 100 | 2001-10-01 | 2017-03-01 |
Ehlers-Danlos Syndrome, Type IV (3) · Dissection, Ascending Aorta (2) · Aneurysm, Ascending Aorta (1) · Aortic Aneurysm, Thoracic (1) · Hemorrhage (1) · Inflammation (1) · Marfan Syndrome (1)
Aneurysm (9) · Cardiovascular Diseases (9) · Dissection, Blood Vessel (9) · Vascular Diseases (9) · Acute Aortic Syndrome (6) · Aortic Diseases (6) · Congenital Abnormalities (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Connective Tissue Diseases (4) · Genetic Diseases, Inborn (4) · Skin and Connective Tissue Diseases (4) · Collagen Diseases (3) · Ehlers-Danlos Syndrome (3) · Hematologic Diseases (3)
Atenolol (1) · BID protein, human (1) · Celiprolol (1) · Irbesartan (1) · Ketorolac (1) · Losartan (1) · Prostheses and Implants (1) · Sodium Chloride (1) · acetyl-(arginyl-alanyl-aspartyl-alanyl)4-amide (1) · enzastaurin (1)
Acer Therapeutics Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Aytu BioPharma, Inc. (1) · Beijing Anzhen Hospital (1) · Carelon Research (1) · Stanford University (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · University of Rostock (1) · University of Sao Paulo General Hospital (1)
United States (4) · Belgium (1) · Brazil (1) · Canada (1) · China (1) · France (1) · Germany (1)
Christoph A Nienaber, MD (1) · Daniel Yung-Ho Sze (1) · DongJin Wang, MD (1) · Ricardo R Dias, MD,PhD (1) · Ron Lacro, MD (1) · Shaine Morris, M.D.,M.P.H. (1) · Sheng Wang, PhD (1) · Sherene Shalhub, M.D., M.P.H. (1) · Tuo Pan, MD (1)
PMID 19996018, PMID 20825986, PMID 23622922, PMID 23630948, PMID 23922146, PMID 25405392, PMID 29948025, PMID 38695613, PMID 39906986
2015 (1), U01HL068270 (1)