8 completed, 3 withdrawn, 1 active not recruiting, 1 enrolling by invitation. 10 Not applicable, 2 Early Phase 1, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 6, Withdrawn 2, Active not recruiting 1, Recruiting 1 |
| Early Phase 1 | 2 | Enrolling by invitation 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
Follow Alertness: new trials by email Literature Review of Alertness trials Research Report on Alertness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Impact of Energy Drink Formulas on Alertness for an Extended Period All beverages are flavor and color matched, Flavored carbonated beverage, color-matched - Alertness | Not applicable | Completed | PepsiCo Global R&D | 48 | 2026-01-26 | 2026-07-24 |
| tFUS to Enhance Alertness and Performance Transcranial Focused Ultrasound - Reaction Time, Alertness | Early Phase 1 | Withdrawn | Medical University of South Carolina | 2025-08-01 | 2025-09-08 | |
| Impact of Canadian Haskap Berry Powder on Hypertension and Acuity in Women's Health Haskap Berry Powder, Placebo Powder - Hypertension, Alertness | Not applicable | Active not recruiting | University of Manitoba | 32 | 2025-04-03 | 2025-12-04 |
| The Impact of Light Intensity in Home Workplaces on Remote Workers' Health Bright Lighting, Placebo Lighting - Daytime Cognitive Performance, Sleep | Not applicable | Withdrawn | Arizona State University | 2024-12-01 | 2023-07-21 | |
| Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures GLP-1, Placebo - Longevity, Quality of Life | Early Phase 1 | Enrolling by invitation | AgelessRx | 150 | 2024-11-01 | 2025-07-30 |
| Lifestyle Coaching for Fatigue Mitigation in Emergency Medicine Residents Personalized lifestyle coaching and educational handout, Handout - Lifestyle, Healthy, Sleepiness | Not applicable | Withdrawn | Stanford University | 2024-03-31 | 2026-04-24 | |
| Investigation of a Dietary Supplement Liquid Shot Product on Aspects of Mood Both At Rest and During a Laboratory Stressor Task. Functional Shot, Placebo Shot - Mood, Stress | Not applicable | Completed | The Water Street Collective | 48 | 2023-01-14 | 2025-01-21 |
| Evaluating the Potentials of Biodynamic Lighting for Home Office Workers Biodynamic, Active Placebo - Cognitive Performance, Sleep | Not applicable | Completed | Arizona State University | 20 | 2022-10-01 | 2024-07-30 |
| Acoustic Stimulation During Restricted Sleep After Sleep Deprivation Philips SmartSleep Acoustic Stimulation Device, Sham (no Acoustic Stimulation) - Sleep Deprivation, Sleep Restriction | Not applicable | Recruiting | Walter Reed Army Institute of Research (WRAIR) | 44 | 2022-03-14 | 2024-04-23 |
| Characterizing the Pharmacokinetic Profile of a Novel Encapsulated Caffeine Beverage and Associated Mood and Physiological Effects Flavored caffeinated beverage - Alertness | Phase 1 | Completed | PepsiCo Global R&D | 75 | 2021-10-08 | 2022-03-24 |
| Effect of Coffeeberry on Mood and Cognitive Performance Placebo, Coffeeberry, Caffeine - Mental Fatigue, Alertness | Not applicable | Completed | PepsiCo Global R&D | 72 | 2021-07-05 | 2022-03-24 |
| Effect of Coffeeberry on Mood, Motivation and Cognitive Performance Cherry-flavored still beverage, Placebo cherry-flavored still beverage - Fatigue, Mental, Alertness | Not applicable | Completed | PepsiCo Global R&D | 30 | 2016-06-28 | 2021-07-23 |
| A Randomized, Placebo-Controlled, Double-Blind, Crossover Study to Evaluate the Effects of Three Doses of the Dietary Supplement oréVida™ on Alertness, Attention and Concentration in Healthy Men and Women oréVida™, Placebo - Attention, Memory | Phase 1 | Completed | dsm-firmenich Switzerland AG | 44 | 2010-03-01 | 2011-06-09 |
| Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars Bright Light Box - Sleep, Alertness | Not applicable | Completed | Brigham and Women's Hospital | 25 | 2008-08-01 | 2015-04-30 |
Mental Fatigue (2) · Agnosia (1) · Fatigue (1) · Hypertension (1) · Inflammation (1) · Occupational Stress (1) · Sleep Deprivation (1) · Sleepiness (1)
Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Behavior (3) · Behavioral Symptoms (3) · Fatigue (2) · Nervous System Diseases (2) · Neurologic Manifestations (2) · Cardiovascular Diseases (1) · Dyssomnias (1) · Mental Disorders (1) · Neurobehavioral Manifestations (1) · Occupational Diseases (1) · Pathologic Processes (1) · Perceptual Disorders (1) · Sleep Wake Disorders (1)
Caffeine (1) · Glucagon-Like Peptide 1 (1) · semaglutide (1)
PepsiCo Global R&D (4) · Arizona State University (2) · AgelessRx (1) · Brigham and Women's Hospital (1) · Medical University of South Carolina (1) · Stanford University (1) · The Water Street Collective (1) · University of Manitoba (1) · Walter Reed Army Institute of Research (WRAIR) (1) · dsm-firmenich Switzerland AG (1)
United States (8) · United Kingdom (3) · Canada (1) · Russia (1)
Al'ai Alvarez, MD (1) · Charles A Czeisler, Ph.D., M.D. (1) · Crystal Haskell-Ramsay, PhD (1) · Kathleen Kelley, MD (1) · Maryam S Makowski, PhD (1) · Nastaran Shishegar, PhD (1) · Patrick J O'Connor (1) · Philippa Jackson, PhD (1) · Semone Myrie, PhD (1) · Swarna Yadlapalli, MD (1)