23 completed, 15 unknown, 4 not yet recruiting, 4 terminated. 50 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 50 | Completed 23, Unknown 15, Not yet recruiting 4, Terminated 4, Recruiting 2, Withdrawn 2 |
Follow Agranulocytosis: new trials by email Literature Review of Agranulocytosis trials Research Report on Agranulocytosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy - Febrile Neutropenia (FN), Pediatric Cancer | Phase 4 | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 136 | 2026-06-01 | 2026-05-15 |
| Letermovir vs Valganciclovir in CMV R+ Kidney Transplant Letermovir, Valganciclovir CMV Prophylaxis - CMV Infection, CMV | Phase 4 | Not yet recruiting | Elisabeth Kincaide | 300 | 2026-05-01 | 2026-05-08 |
| Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During Induction Phase Levofloxacin, Placebo - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Terminated | Gadjah Mada University | 49 | 2026-01-01 | 2026-10-01 |
| Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia G-CSF, Antibiotics only - Febrile Neutropenia, Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy | Phase 4 | Not yet recruiting | King Edward Medical University | 150 | 2025-06-01 | 2025-05-25 |
| Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies Ceftazidime, Ciprofloxacin - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Recruiting | Gadjah Mada University | 120 | 2025-06-01 | 2025-08-22 |
| Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing Pathogens Ceftolozane-Tazobactam, Meropenem - Febrile Neutropenia | Phase 4 | Recruiting | Beneficência Portuguesa de São Paulo | 55 | 2025-03-26 | 2026-09-18 |
| Outcomes of Early and Late Administration G-CSF for Primary Prophylaxis in Non-Hodgkin's Lymphoma Patients Early receiving G-CSF group, Late receiving G-CSF group - Non-Hodgkin's Lymphoma (NHL), Granulocyte Colony Stimulating Factor | Phase 4 | Not yet recruiting | Department of Medical Services Ministry of Public Health of Thailand | 126 | 2025-02-01 | 2025-01-28 |
| Compare the Efficacy and Safety of QL0605 Injections at Different Timepoints QL0605(PEG-rhG-CSF) - Chemotherapy-Induced Febrile Neutropenia | Phase 4 | Unknown | Qilu Pharmaceutical Co., Ltd. | 336 | 2024-09-19 | 2024-09-27 |
| Antimicrobial Revision in Persistent Febrile Neutropenia Meropenem, Micafungin - Febrile Neutropenia | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2024-08-01 | 2024-09-19 | |
| Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance Dosage Adjustment Rules for Augmented Renal Clearance (DAR-ARC) for piperacillin-tazobactam and meropenem, Standard dosages of piperacillin-tazobactam or meropenem - Febrile Neutropenia | Phase 4 | Unknown | Centre Hospitalier Universitaire Vaudois | 30 | 2024-03-01 | 2024-07-11 |
| Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia Comparison short vs extended EBAT treatment group - Neutropenia, Febrile | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 450 | 2024-02-26 | 2026-10-23 |
| Continuous Versus Bolus Administration of G-CSF in Children With Cancer G-CSF administration (bolus injection versus intravenous infusion) - Pediatric Cancer, Neutropenia | Phase 4 | Unknown | Chang Gung Memorial Hospital | 20 | 2023-11-23 | 2024-09-19 |
| Letermovir for Secondary Prophylaxis in Solid Organ Transplant Recipients Letermovir - Cytomegalovirus Infections, Infection in Solid Organ Transplant Recipients | Phase 4 | Completed | Tufts Medical Center | 21 | 2023-02-02 | 2026-10-26 |
| Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection Meropenem Injection, Levofloxacin, Amoxicillin Clavulanate - Neutropenic Fever | Phase 4 | Unknown | The University of Hong Kong | 344 | 2022-10-24 | 2022-12-06 |
| CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients Ceftolozane-tazobactam IV - Neutropenia, Febrile, Hematologic Cancer | Phase 4 | Withdrawn | Hamad Medical Corporation | 2022-08-01 | 2023-08-14 | |
| Letermovir Use in Heart Transplant Recipients Letermovir - Cytomegalovirus Disease, Cytomegalovirus Infections | Phase 4 | Completed | Tufts Medical Center | 32 | 2022-01-05 | 2025-07-29 |
| Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia Simvastatin - Strains, Acute Lymphoblastic Leukemia | Phase 4 | Unknown | Hospital General de Mexico | 108 | 2021-11-19 | 2022-01-04 |
| Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia Piperacillin and Tazobactam for Injection, Cefepime Injection, Ceftazidime Injection - Febrile Neutropenia | Phase 4 | Completed | Murdoch Childrens Research Institute | 55 | 2021-11-15 | 2026-03-20 |
| Efficacy and Safety of 4.5mg PEG-rhG-CSF Per Cycle in Preventing Neutropenia After Intensive Chemotherapy for Breast Cancer PEG-rhG-CSF - Breast Cancer, Neutropenia | Phase 4 | Completed | Peking University | 104 | 2019-08-01 | 2020-10-28 |
| Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patients Piperacillin-Tazobactam 4 g-0.5 g, Cefepime 2000 mg, Meropenem 1000 mg - Febrile Neutropenia | Phase 4 | Unknown | Hospital Universitari de Bellvitge | 150 | 2019-06-05 | 2021-02-12 |
Showing 20 of 50. Sign in to see all of them.
Febrile Neutropenia (28) · Neutropenia (28) · Neoplasms (12) · Fever (6) · Breast Neoplasms (4) · Lymphoma, Non-Hodgkin (4) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (4) · Sepsis (4) · Chemotherapy-Induced Febrile Neutropenia (3) · Cytomegalovirus Infections (3) · Hematologic Neoplasms (3) · Leukemia (3) · Leukemia, Myeloid, Acute (3) · Acquired Immunodeficiency Syndrome (2) · Anemia (2)
Cytopenia (50) · Hemic and Lymphatic Diseases (50) · Leukocyte Disorders (50) · Leukopenia (50) · Hematologic Diseases (49) · Neutropenia (22) · Neoplasms (17) · Infections (13) · Neoplasms by Histologic Type (12) · Pathological Conditions, Signs and Symptoms (11) · Immune System Diseases (10) · Neoplasms by Site (9) · Immunoproliferative Disorders (8) · Lymphoproliferative Disorders (8)
Meropenem (8) · Ceftazidime (5) · Cefepime (4) · Ciprofloxacin (4) · Vancomycin (4) · Filgrastim (3) · letermovir (3) · pegfilgrastim (3) · Amikacin (2) · Cilastatin, Imipenem Drug Combination (2) · Granulocyte Colony-Stimulating Factor (2) · Levofloxacin (2) · Micafungin (2) · Piperacillin, Tazobactam Drug Combination (2) · Teicoplanin (2)
Amgen (3) · Asan Medical Center (2) · Gadjah Mada University (2) · Tufts Medical Center (2) · Amsterdam UMC, location VUmc (1) · Anglo Celtic Cooperative Oncology Group (1) · Assistance Publique - Hôpitaux de Paris (1) · Beneficência Portuguesa de São Paulo (1) · Centre Hospitalier Universitaire Vaudois (1) · Chang Gung Memorial Hospital (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Elisabeth Kincaide (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Gary E. Stein, Pharm.D. (1) · Gilead Sciences (1)
United States (7) · China (4) · Spain (4) · Indonesia (3) · South Korea (3) · Australia (2) · Belgium (2) · Israel (2) · Thailand (2) · Belarus (1) · Botswana (1) · Brazil (1) · France (1) · Germany (1) · Greece (1)
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PMID 12084168, PMID 15770833, PMID 16096770, PMID 17470691, PMID 17621407, PMID 18165618, PMID 20118030, PMID 20163377, PMID 20232087, PMID 21876446, PMID 22290953, PMID 23317527, PMID 24086319, PMID 28374097, PMID 28419427, PMID 29153975, PMID 29608680, PMID 30208456, PMID 31554370, PMID 32418789, PMID 32423462, PMID 33041718, PMID 34208815, PMID 34494505, PMID 35691326, PMID 35785754, PMID 39115709, PMID 39696092, PMID 40396505
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