8 recruiting, 6 completed, 4 unknown, 3 active not recruiting. 12 Phase 2, 9 Phase 1, 1 Not applicable, 1 Phase 4.
Follow Advanced Colorectal Carcinoma: new trials by email Literature Review of Advanced Colorectal Carcinoma trials Research Report on Advanced Colorectal Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Engage Psychosocial Intervention for Cancer Symptoms ENGAGE, Supportive Care - Advanced Breast Cancer, Advanced Prostate Cancer | Not applicable | Recruiting | Duke University | 190 | 2025-06-11 | 2026-03-16 |
| Phase II Study of Serplulimab Combined with First-Line Targeted Therapy, Chemotherapy, and Radiation in Advanced Colorectal Cancer Serplulimab, Chemotherapy, SABR - Advanced Colorectal Carcinoma, Immunotherapy | Phase 2 | Recruiting | Fudan University | 208 | 2025-03-01 | 2025-03-14 |
| Molecular Study and Precision Medicine for Colorectal Cancer Molecular Profiling & drug testing in tumor organoids and PDXs - Advanced Colorectal Carcinoma, Recurrent Colorectal Carcinoma | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 100 | 2024-10-01 | 2024-07-24 | |
| LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Recruiting | University of Rochester | 800 | 2023-12-04 | 2026-01-09 | |
| First-line Maintenance of OH2 Injection for Advanced Colorectal Cancer OH2, Capecitabine, Bevacizumab - Advanced Colorectal Carcinoma | Phase 2 | Terminated | Binhui Biopharmaceutical Co., Ltd. | 7 | 2023-10-17 | 2024-04-30 |
| Survival Benefit of Compound Kushen Injection in the Treatment of Advanced Colorectal Cancer first-line scheme+compound kushen injection, palliative care group first-line scheme - Advanced Colorectal Carcinoma | Phase 4 | Recruiting | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 320 | 2023-09-27 | 2024-12-27 |
| At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer Clinical Encounter, Home Health Encounter, Quality-of-Life Assessment - Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 220 | 2023-08-23 | 2026-04-20 |
| The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors Fermented Wheat Germ Extract - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 | Suspended | University of California, Davis | 100 | 2023-06-02 | 2026-07-01 |
| Understanding New Cachexia Subtypes Through Observational Epidemiological Research Biospecimen Collection, Computed Tomography, Electronic health record review - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Recruiting | Kaiser Permanente | 800 | 2023-04-05 | 2026-08-20 | |
| CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors Biospecimen Collection, Computed Tomography, Devimistat - Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma | Phase 2 | Recruiting | Northwestern University | 94 | 2023-03-08 | 2023-03-10 |
| First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients With Selected Advanced and/or Metastatic Solid Tumours OATD-02 - Advanced Ovarian Carcinoma, Advanced Renal Cell Carcinoma | Phase 1 | Recruiting | Molecure S.A. | 40 | 2023-01-26 | 2026-07-31 |
| A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer VS-6766/avutometinib, Cetuximab, Pill Diary - Colorectal Cancer, Colorectal Adenocarcinoma | Phase 1 / Phase 2 | Suspended | University of Chicago | 53 | 2022-08-22 | 2026-05-08 |
| Hepatic Arterial Infusion Chemotherapy With Fruquintinib for Colorectal Cancer Liver Metastases As Third-line Therapy Fruquintinib, Hepatic Arterial Infusion Chemotherapy - Advanced Colorectal Carcinoma, Liver Metastasis Colon Cancer | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 27 | 2022-02-25 | 2022-06-06 |
| Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines Biopsy Procedure, Biospecimen Collection, Diagnostic Imaging Testing - Advanced Colorectal Carcinoma, Advanced Digestive System Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 10 | 2021-08-13 | 2026-08-21 |
| Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial Biopsy Procedure, Biospecimen Collection, Ceralasertib - Advanced Breast Carcinoma, Advanced Colon Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 51 | 2021-08-09 | 2026-09-04 |
| Combining Epigenetic And Immune Therapy to Beat Cancer. Durvalumab, Tazemetostat - Advanced Solid Tumor, Advanced Colorectal Carcinoma | Phase 2 | Completed | Institut Bergonié | 164 | 2021-07-23 | 2026-03-06 |
| A Dose Escalation Study of APR003 in Patients With Advanced Colorectal Cancer (CRC) With Malignant Liver Lesions APR003 - Advanced Colorectal Carcinoma | Phase 1 | Terminated | Apros Therapeutics, Inc | 11 | 2021-01-19 | 2025-08-06 |
| Fruquintinib and Raltitrexed Versus Fruquintinib Monotherapy in Advanced Colorectal Cancer Fruquintinib and raltitrexed, Fruquintinib - Advanced Colorectal Carcinoma | Phase 2 | Unknown | Fudan University | 136 | 2020-09-28 | 2021-10-26 |
| Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab Bevacizumab, Dasatinib, Fluorouracil - Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma | Phase 1 | Completed | Anne Noonan | 9 | 2020-09-02 | 2024-12-27 |
| TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study Irinotecan, Bevacizumab, Trifluridine and Tipiracil Hydrochloride - Advanced Colorectal Carcinoma, Metastatic Colon Adenocarcinoma | Phase 2 | Completed | Roswell Park Cancer Institute | 42 | 2019-12-27 | 2026-02-10 |
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Colorectal Neoplasms (14) · Pancreatic Neoplasms (7) · Lung Neoplasms (5) · Colonic Neoplasms (3) · Stomach Neoplasms (3) · Carcinoma, Renal Cell (2) · Ovarian Neoplasms (2) · Rectal Neoplasms (2) · Adenocarcinoma (1) · Adenocarcinoma of Lung (1) · Agnosia (1) · Bile Duct Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Transitional Cell (1)
Neoplasms (15) · Colonic Diseases (13) · Digestive System Diseases (13) · Digestive System Neoplasms (13) · Gastrointestinal Diseases (13) · Gastrointestinal Neoplasms (13) · Intestinal Diseases (13) · Intestinal Neoplasms (13) · Neoplasms by Site (13) · Rectal Diseases (13) · Neoplasms by Histologic Type (7) · Endocrine Gland Neoplasms (6) · Endocrine System Diseases (6) · Pancreatic Diseases (6) · Carcinoma (4)
Specimen Handling (5) · Fluorouracil (4) · Magnetic Resonance Spectroscopy (4) · Bevacizumab (3) · Disulfides (3) · Leucovorin (3) · dehydroftorafur (3) · Biopsy (2) · Exercise Test (2) · HMPL-013 (2) · Immunoglobulin G (2) · Irinotecan (2) · Oxaliplatin (2) · durvalumab (2) · Avemar (1)
Fudan University (2) · National Cancer Institute (NCI) (2) · 4SC AG (1) · Anne Noonan (1) · Apros Therapeutics, Inc (1) · Binhui Biopharmaceutical Co., Ltd. (1) · Duke University (1) · Genzyme, a Sanofi Company (1) · Guang'anmen Hospital of China Academy of Chinese Medical Sciences (1) · Institut Bergonié (1) · Kaiser Permanente (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Molecure S.A. (1) · Mologen AG (1)
United States (13) · China (7) · France (2) · Germany (2) · Australia (1) · Austria (1) · Czechia (1) · Poland (1) · Russia (1) · United Kingdom (1)
Aaron Weitzman, MD (1) · Anne M Noonan, MBBChBAO, MSc (1) · Ardaman S. Shergill, MD (1) · Christos Fountzilas, MD (1) · David S Hong (1) · Devalingam Mahalingam (1) · Hans-Joachim Schmoll (1) · Joseph M Tuscano, MD (1) · Kanwal P Raghav (1) · Liza C Villaruz (1) · Richard F Dunne (1) · Roxana S. Dronca, MD (1) · Trinh Le (1)
PMID 29946728, PMID 31999946, PMID 33142018, PMID 34689233, PMID 39244627, PMID 39741233, PMID 39841295, PMID 39886125, PMID 40834926, PMID 9006748
2009 (1), 2019 (1), OT2CA278691 (1), P30CA060553 (1), P30CA093373 (1), R01CA291768 (1), UG1CA189961 (1), UM1CA186688 (1), UM1CA186690 (1)