116 completed, 48 terminated, 47 recruiting, 21 active not recruiting. 273 Phase 1, 87 Phase 2.
Follow Adenoma: new trials by email Literature Review of Adenoma trials Research Report on Adenoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Efficacy and Safety of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural Mesothelioma Ivonescimab Combined With Chemotherapy - Malignant Pleural Mesothelioma, Advanced | Phase 1 / Phase 2 | Recruiting | Ruijin Hospital | 78 | 2026-11-01 | 2026-10-26 |
| S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas S-Adenosylmethionine (SAMe) - Colorectal Cancer (Diagnosis), Adenoma | Phase 1 | Not yet recruiting | Jun Gong, MD | 18 | 2026-11-01 | 2026-08-04 |
| TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors TLN-499, Venetoclax - Small Cell Lung Cancer ( SCLC ), Neuroendocrine Cancer | Phase 1 | Recruiting | Treeline Biosciences, Inc. | 120 | 2026-08-05 | 2026-10-01 |
| FAPI PET Imaging - An Exploratory Study [18F]FAPI-74 PET/CT - Thyroid Pathology, Head and Neck Cancer (H&N) | Phase 1 / Phase 2 | Not yet recruiting | Martin Huellner | 770 | 2026-08-01 | 2026-07-15 |
| A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors SHY-ONC6 - Advanced or Metastatic Solid Tumors, Triple Negative Breast Cancer (TNBC) | Phase 1 | Recruiting | SHY Therapeutics | 30 | 2026-06-24 | 2026-10-22 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| A 2-part Phase 1/2 Open-label Trial on ODM-212 ODM-212, Ipilimumab and nivolumab, Gemcitabine and nab-paclitaxel - Mesothelioma, Pancreatic Cancer | Phase 1 / Phase 2 | Recruiting | Orion Corporation, Orion Pharma | 229 | 2026-03-27 | 2026-10-22 |
| A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors IDE892, IDE397 - NSCLC Adenocarcinoma, Gastroesophageal Cancer (GC) | Phase 1 | Recruiting | IDEAYA Biosciences | 260 | 2026-03-04 | 2026-09-28 |
| Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma EB-MF-CAR-NK-01, Fludarabine, Cyclophosphamide - Malignant Pleural Mesotheliomas | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 36 | 2026-03-02 | 2026-04-06 |
| Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma Tegavivint - Metastatic Colorectal Carcinoma (mCRC), Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Recruiting | HonorHealth Research Institute | 126 | 2026-02-17 | 2026-03-11 |
| Study of TYK-01054 Capsules in Patients With Advanced Solid Tumors TYK-01054 - Solid Tumor Malignancies, Malignant Mesothelioma (MM) | Phase 1 / Phase 2 | Not yet recruiting | TYK Medicines, Inc | 219 | 2026-01-01 | 2025-12-22 |
| Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs. RYZ401 - GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor | Phase 1 | Recruiting | RayzeBio, Inc. | 104 | 2025-12-03 | 2026-09-15 |
| Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors Biopsy, Biospecimen Collection, Computed Tomography - Metastatic Malignant Solid Neoplasm, Metastatic Melanoma | Phase 1 | Recruiting | Anusha Kalbasi | 18 | 2025-10-07 | 2026-03-17 |
| Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 Biopsy Procedure, Biospecimen Collection, Colonoscopy - Colorectal Adenomatous Polyp, Colorectal Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2025-10-06 | 2026-10-15 |
| Study of Iparomlimab and Tuvonralimab Plus Chemotherapy in Malignant Mesothelioma iparomlimab and tuvonralimab (Dual PD-1/CTLA-4 blockade) + chemotherapy - Malignant Mesothelioma, Mesothelioma | Phase 1 / Phase 2 | Not yet recruiting | National Cancer Center, China | 55 | 2025-09-01 | 2025-08-20 |
| R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors R-5780 - Solid Tumor, Adult, Solid Tumor | Phase 1 | Recruiting | Rise Therapeutics LLC | 33 | 2025-08-01 | 2026-09-18 |
| NEoadjuvant Chemotherapy and Immunotherapy for a Selected Group of Inoperable Pleural Mesothelioma Patients (NECIM): a Feasibility Study Neoadjuvant chemo-immunotherapy, Extended pleurectomy/decortication in case of reaching operability - Pleural Epithelioid Mesothelioma, Mesothelioma; Pleura | Phase 1 / Phase 2 | Recruiting | University Hospital, Antwerp | 37 | 2025-07-22 | 2025-08-13 |
| Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma cyclophosphamide, fludarabine, TNhYP218 CAR T Cells - Mesothelioma, Neoplasms | Phase 1 | Recruiting | National Cancer Institute (NCI) | 120 | 2025-07-08 | 2026-10-16 |
Showing 20 of 273. Sign in to see all of them.
Mesothelioma (129) · Mesothelioma, Malignant (124) · Carcinoma, Non-Small-Cell Lung (89) · Ovarian Neoplasms (54) · Melanoma (50) · Stomach Neoplasms (46) · Pancreatic Neoplasms (44) · Colorectal Neoplasms (42) · Carcinoma, Renal Cell (41) · Esophageal Neoplasms (40) · Lung Neoplasms (39) · Neoplasms (39) · Uterine Cervical Neoplasms (38) · Breast Neoplasms (35) · Neoplasm Metastasis (31)
Neoplasms, Glandular and Epithelial (273) · Neoplasms by Histologic Type (272) · Neoplasms by Site (249) · Neoplasms (234) · Neoplasms, Mesothelial (231) · Thoracic Neoplasms (197) · Respiratory Tract Neoplasms (196) · Lung Diseases (194) · Respiratory Tract Diseases (194) · Lung Neoplasms (157) · Digestive System Diseases (133) · Digestive System Neoplasms (132) · Pleural Neoplasms (127) · Endocrine System Diseases (108)
Cisplatin (31) · Pemetrexed (30) · pembrolizumab (28) · Cyclophosphamide (16) · Nivolumab (11) · Carboplatin (9) · Drug Therapy (7) · Ipilimumab (7) · Everolimus (6) · fludarabine (6) · Gemcitabine (5) · Interleukin-2 (5) · Paclitaxel (5) · Platinum (5) · aldesleukin (5)
National Cancer Institute (NCI) (32) · Memorial Sloan Kettering Cancer Center (11) · M.D. Anderson Cancer Center (7) · Novartis Pharmaceuticals (6) · Dana-Farber Cancer Institute (5) · Incyte Corporation (5) · University of Chicago (5) · Abramson Cancer Center at Penn Medicine (4) · Erasmus Medical Center (4) · Incyte Biosciences International Sàrl (4) · University Hospital, Antwerp (4) · Bayer (3) · NGM Biopharmaceuticals, Inc (3) · Roswell Park Cancer Institute (3) · University of Pennsylvania (3)
United States (202) · United Kingdom (25) · France (21) · Spain (21) · Canada (20) · Australia (19) · China (19) · Italy (12) · Japan (12) · Netherlands (11) · Belgium (10) · Germany (8) · South Korea (8) · Switzerland (8) · Puerto Rico (5)
David S Schrump, M.D. (7) · Raffit Hassan, M.D. (6) · Raffit Hassan, MD (3) · Andrew Haas, MD, PhD (2) · Anne S Tsao (2) · Anne S. Tsao, MD (2) · David S. Schrump, MD (2) · Dean Fennell (2)
PMID 36104949, PMID 42580817, PMID 11487589, PMID 15764728, PMID 16554548, PMID 17295916, PMID 17395581, PMID 18797818, PMID 19192962, PMID 19360120, PMID 19564349, PMID 19671873, PMID 20068553, PMID 20167848, PMID 20234350, PMID 20400682, PMID 20549206, PMID 20615924, PMID 20847174, PMID 21135147, PMID 21149657, PMID 21467219, PMID 21632857, PMID 21642245, PMID 22065672, PMID 22736724, PMID 22778767, PMID 23032745, PMID 23148753, PMID 23248097, PMID 23475104, PMID 23785047, PMID 24148817, PMID 2418164, PMID 24366885, PMID 24445595, PMID 24484236, PMID 24487185, PMID 24739759, PMID 24777247, PMID 24777970, PMID 24852691, PMID 24942404, PMID 25281915, PMID 25900182, PMID 26652184, PMID 26968202, PMID 28298401, PMID 28525370, PMID 28625637
2019 (6), 2016 (5), 2023 (5), P30CA016672 (4), 2015 (3), 2017 (2), P01CA066726 (2), U01CA062461 (2), U10CA180888 (2), UM1CA186689 (2), UM1CA186717 (2), 2009 (1), 2014 (1), 2018 (1), P01CA023766 (1)