56 completed, 3 unknown, 3 withdrawn, 2 not yet recruiting. 26 Phase 4, 15 Phase 3, 8 Not applicable, 8 Phase 1, 7 Phase 2.
Follow Adapalene: new trials by email Literature Review of Adapalene trials Research Report on Adapalene
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial Acne Clascoterone 1% cream, Clindamycin 1% lotion, Adapalene 0.1%/benzoyl peroxide 2.5% gel - Acne Vulgaris | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 118 | 2026-11-01 | 2026-10-19 |
| Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris Clascoterone 1% cream, Adapalene 0.1% cream - Acne Vulgaris | Not applicable | Recruiting | Pak Emirates Military Hospital | 130 | 2026-10-08 | 2026-10-22 |
| Radiofrequency Treatment Versus Topical Therapy for Facial Acne Vulgaris Adapalene 0.1% and Benzoyl Peroxide 2.5% gel, Sequential Radiofrequency Treatment - Acne Vulgaris | Not applicable | Recruiting | Jeisys Medical Inc | 60 | 2026-09-15 | 2026-09-04 |
| Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study Spironolactone 5% Topical Gel, Adapalene 0.1% Topical Gel - Acne Vulgaris | Phase 2 | Not yet recruiting | Assiut University | 40 | 2026-04-01 | 2026-03-17 |
| Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris clindamycin phosphate, adapalene and benzoyl peroxide - Acne Vulgaris | Completed | Bausch Health Americas, Inc. | 200 | 2025-10-02 | 2026-09-09 | |
| Auricular Acupressure Combined With Adapalene for the Treatment of Acne Vulgaris Auricular Acupressure, Adapalene 0.1% Gel - Acne Vulgaris | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 64 | 2024-11-01 | 2026-01-16 |
| A Study Comparing Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2% (Taro Pharmaceuticals U.S.A., Inc.) and CABTREO Topical Gel for the Treatment of Acne Vulgaris. Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2%, CABTREO Topical Gel, Placebo Control - Acne Vulgaris | Phase 1 | Completed | Sun Pharmaceutical Industries, Inc. | 382 | 2024-05-13 | 2024-11-05 |
| Vitamin D Supplementation in Acne D Max Drops, Azithromycin 250 milligram Oral Capsule, Adapalene - Acne Vulgaris | Not applicable | Completed | HITEC-Institute of Medical Sciences | 58 | 2024-02-24 | 2026-05-19 |
| Experience With Topical Acne Treatment clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel, adapalene 0.3%/BPO 2.5% gel and compounded clindamycin phosphate 1.2% gel, Compounded BPO 2.5% gel, adapalene 0.1% gel, and compounded clindamycin phosphate 1.2% gel - Acne | Early Phase 1 | Active not recruiting | Wake Forest University Health Sciences | 72 | 2024-02-15 | 2025-12-24 |
| A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne Winlevi (clascoterone) 1% & Adapalene 0.3% gel - Acne Vulgaris | Phase 4 | Completed | Sun Pharmaceutical Industries Limited | 20 | 2023-11-15 | 2025-10-09 |
| Effect of New Topical Preparation for Treatment of Acne Vulgaris DAP-FLU ME, Adapalene .1% gel - Acne Vulgaris | Phase 2 | Unknown | Mansoura University | 20 | 2023-06-05 | 2023-06-13 |
| "A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients." Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, Topical Adapalene, Benzoyl Peroxide Gel - Acne Vulgaris | Not applicable | Unknown | Treatment and Diagnostic Center of Private Enterprise "Asklepiy" | 59 | 2022-02-18 | 2023-05-11 |
| Clinical Endpoint Bioequivalence Study of Adapalene Gel 0.1% Adapalene 0.1% Gel, Differin 0.1% Topical Gel, Placebo - Acne Vulgaris | Phase 3 | Withdrawn | Aurobindo Pharma Ltd | 2020-07-01 | 2020-06-26 | |
| A Study Comparing Adapalene Gel 0.1% and to Differin Gel in the Treatment of Acne Vulgaris Adapalene Gel 0.1%, Placebo Control, Differin® Gel (Adapalene 0.1%, Galderma) - Acne Vulgaris | Early Phase 1 | Completed | Sun Pharmaceutical Industries, Inc. | 978 | 2020-05-18 | 2021-04-01 |
| Role of Vitamin D and Its Topical Analogues in Pathogenesis and Treatment of Acne Vulgaris Vitamin D analog, Adapalene - Acne Vulgaris | Phase 4 | Unknown | Assiut University | 80 | 2019-10-01 | 2019-03-12 |
| Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients Zinc gluconate, Adapalene 0.003 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo], Placebo - Acne Vulgaris | Phase 4 | Completed | East Avenue Medical Center, Philippines | 23 | 2018-12-21 | 2022-05-11 |
| Bioequivalence Study of Adapalene Gel 0.3% in Subjects With Facial Acne Vulgaris Adapalene Gel 0.3%, Differin 0.3% Topical Gel, Adapalene Gel 0.3% Vehicle Placebo - Acne Vulgaris | Phase 3 | Completed | Aleor Dermaceuticals Limited | 755 | 2018-09-17 | 2019-04-26 |
| A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris Adapalene-Clindamycin Combination Gel, Adapalene Gel, Clindamycin Gel - Acne Vulgaris | Phase 3 | Completed | Lee's Pharmaceutical Limited | 1617 | 2018-08-14 | 2020-04-28 |
| The Functional and Emotional Benefits of Replenix Power of Three With Resveratrol Replenix Power of 3 Cream with resveratrol, Adapalene and Benzoyl peroxide gel, 0.1%/2.5% - Acne Vulgaris | Phase 4 | Terminated | Yardley Dermatology Associates | 43 | 2018-06-04 | 2021-04-23 |
| The Use of Oracea and Epiduo Forte in Severe Acne Patients Doxycycline Anhydrous 40 MG, Adapalene/Benzoyl Peroxide Gel 0.3-2.5% - Acne | Phase 4 | Completed | Derm Research, PLLC | 22 | 2018-03-19 | 2019-04-03 |
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Acne Vulgaris (63) · Dermatitis (1) · Inflammation (1)
Galderma R&D (16) · Stiefel, a GSK Company (4) · Sun Pharmaceutical Industries, Inc. (4) · Allergan (3) · Bausch Health Americas, Inc. (3) · Galderma Laboratorium GmbH (3) · Actavis Mid-Atlantic LLC (2) · Assiut University (2) · Lee's Pharmaceutical Limited (2) · Padagis LLC (2) · Wake Forest University (2) · Ache Laboratorios Farmaceuticos S.A. (1) · Actavis Inc. (1) · Aleor Dermaceuticals Limited (1) · All India Institute of Medical Sciences, Bhubaneswar (1)
United States (33) · Belize (4) · Canada (4) · Germany (3) · India (3) · Mexico (3) · Pakistan (3) · Belgium (2) · Brazil (2) · China (2) · Egypt (2) · Poland (2) · Argentina (1) · Australia (1) · Chile (1)
Michael Graeber, MD (4) · Ronald W Gottschalk, MD (3) · Harald PM Gollnick, Prof. Dr. (2) · Steven R Feldman, MD, PhD (2) · Adelaide Hebert, MD (1) · Alan Fleischer, MD (1) · Alur S. Kumar, MD (1) · Amgad El-Sayed Salem (1) · Ana Rossi, MD (1) · Ananda Quadros Campos (1) · Andrea Zaenglein, MD (1)
PMID 20684151, PMID 11488820, PMID 12095065, PMID 12553848, PMID 12839559, PMID 18249468, PMID 18472984, PMID 19376456, PMID 19439902, PMID 20213916, PMID 21607190, PMID 23652892, PMID 26293170, PMID 28913735, PMID 29537444, PMID 29549598, PMID 31251543, PMID 39487326