21 completed. 11 Phase 4, 5 Phase 3, 1 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Completed 11 |
| Phase 3 | 5 | Completed 5 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow this drug Literature Review of Adapalene, Benzoyl Peroxide Drug Combination trials Research Report on Adapalene, Benzoyl Peroxide Drug Combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anti-acne Efficacy of a Dermo-cosmetic Product Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer in Male and Female Subjects Presenting With Mild to Moderate Acne Epiduo, Salicylic Acid, Hydréane légère - Acne | Phase 4 | Completed | Vichy Laboratoires | 200 | 2019-02-18 | 2021-10-18 |
| Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients Zinc gluconate, Adapalene 0.003 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo], Placebo - Acne Vulgaris | Phase 4 | Completed | East Avenue Medical Center, Philippines | 23 | 2018-12-21 | 2022-05-11 |
| The Use of Oracea and Epiduo Forte in Severe Acne Patients Doxycycline Anhydrous 40 MG, Adapalene/Benzoyl Peroxide Gel 0.3-2.5% - Acne | Phase 4 | Completed | Derm Research, PLLC | 22 | 2018-03-19 | 2019-04-03 |
| Subject Reported Outcomes With Use of Adapalene 0.3% - Benzoyl Peroxide (BPO) 2.5% in Dark Skin Acne Adapalene 0.3% / BPO 2.5% gel - Acne Vulgaris | Phase 3 | Completed | Galderma R&D | 50 | 2017-02-02 | 2021-02-18 |
| A Treatment for Severe Inflammatory Acne Subjects Adapalene 0.3% / benzoyl peroxide 2.5% emulsion gel, Oral doxycycline hyclate - Acne Vulgaris | Phase 4 | Completed | Galderma R&D | 186 | 2016-07-29 | 2022-12-09 |
| Study Comparing Adapalene/BP Gel to EPIDUO® FORTE and Both to a Placebo Control in Treatment of Acne Vulgaris Adapalene/BP gel, 0.3%/2.5%, EPIDUO® FORTE, Placebo - Acne Vulgaris | Phase 1 | Completed | Sun Pharmaceutical Industries, Inc. | 460 | 2015-09-01 | 2017-05-04 |
| A Treatment Regimen for Student Athletes With Mild to Moderate Acne Vulgaris Adapalene/benzoyl peroxide gel, 0.1%/2.5%, Cetaphil Acne Regimen - Acne Vulgaris | Phase 4 | Completed | Galderma R&D | 28 | 2014-08-01 | 2022-08-23 |
| Adapalene BPO Gel Pump, Moisturizer SPF 30 and Foam Wash in Patients With Mild to Moderate Acne Vulgaris Adapalene/BPO Gel, Moisturizer SPF 30, Foam Wash - Acne | Phase 4 | Completed | Galderma R&D | 81 | 2013-10-01 | 2022-08-23 |
| Long-term Study of Epiduo in Patients With Moderate to Severe Acne 0.1% adapalene / 2.5% benzoyl peroxide - Acne Vulgaris | Completed | Galderma Laboratorium GmbH | 6036 | 2012-06-01 | 2016-02-17 | |
| Effect of Samples on Acne Treatment With Epiduo® Gel Adapalene + benzoyl peroxide samples, Adapalene + benzoyl peroxide from standard tube - Acne Vulgaris | Phase 4 | Completed | Wake Forest University | 20 | 2011-12-01 | 2018-09-12 |
| Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne Epiduo/Tactuo, vehicle gel, doxycycline 200mg - Acne | Phase 3 | Completed | Galderma R&D | 266 | 2011-11-01 | 2021-02-18 |
| Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin skinoren, differin - Acne Vulgaris | Phase 4 | Completed | University of Magdeburg | 60 | 2011-08-01 | 2013-07-08 |
| A Bioequivalence Study With Clinical Endpoints Comparing Adapalene and Benzoyl Peroxide Topical Gel 0.1%/2.5% (Actavis Mid-Atlantic LLC) To Epiduo™ (Adapalene and Benzoyl Peroxide) Gel 0.1%/2.5% (Galderma Laboratories, L.P.) in the Treatment of Mild to Severe Acne Vulgaris adapalene 0.1% and benzoyl peroxide 2.5% topical gel, EPIDUO, Placebo (Vehicle Gel) - Acne Vulgaris | Not applicable | Completed | Actavis Mid-Atlantic LLC | 885 | 2011-07-01 | 2011-12-29 |
| Epiduo Pediatric Acne Study adapalene/benzoyl peroxide, Topical Gel Vehicle - Acne | Phase 4 | Completed | Galderma R&D | 285 | 2010-06-01 | 2021-02-18 |
| Efficacy of Epiduo and Treatment Adherence of Adolescent Patients With Inflammatory Acne 0.1% adapalene/ 2.5% benzoyl peroxide - Acne | Completed | Galderma Laboratorium GmbH | 3113 | 2010-05-01 | 2016-02-17 | |
| Exploratory Study to Evaluate the Efficacy and Safety of CD07223 Gel in Subjects With Acne Epiduo vehicle gel, CD07223, Epiduo (adapalene and benzoyl peroxide) 0.1%/2.5% gel - Acne | Phase 2 | Completed | Galderma R&D | 73 | 2010-04-01 | 2021-02-18 |
| Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel Epiduo gel, BPO - Acne Vulgaris | Phase 4 | Completed | Galderma R&D | 40 | 2010-03-01 | 2021-02-18 |
| A Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris Adapalene/Benzoyl Peroxide, Adapalene, Benzoyl Peroxide - Acne Vulgaris | Phase 3 | Completed | Galderma R&D | 1670 | 2006-10-01 | 2021-02-18 |
| Measuring Adherence in Subjects With Acne Vulgaris in a Clinic Population Subtitle: Topical Benzoyl Peroxide for Acne Benzoyl Peroxide - Acne Vulgaris | Phase 4 | Completed | Wake Forest University | 20 | 2006-07-01 | 2018-08-28 |
| Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris Adapalene/Benzoyl Peroxide, Adapalene Gel, 0.1%, Benzoyl Peroxide Gel 2.5% - Acne Vulgaris | Phase 3 | Completed | Galderma R&D | 1668 | 2006-06-27 | 2024-04-15 |
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Acne Vulgaris (21) · Inflammation (1)
Galderma R&D (11) · Galderma Laboratorium GmbH (2) · Wake Forest University (2) · Actavis Mid-Atlantic LLC (1) · Derm Research, PLLC (1) · East Avenue Medical Center, Philippines (1) · Sun Pharmaceutical Industries, Inc. (1) · University of Magdeburg (1) · Vichy Laboratoires (1)
United States (13) · Canada (3) · Germany (2) · Poland (2) · Belize (1) · France (1) · Hungary (1) · India (1) · Mauritius (1) · Philippines (1) · Singapore (1)
Michael Graeber, MD (5) · Harald PM Gollnick, Prof. Dr. (2) · Adelaide Hebert, MD (1) · Alan Fleischer, MD (1) · Andrea Zaenglein, MD (1) · Anja Thielitz, Dr. med. (1) · Boni Elewski, MD (1) · Charles Lynde, MD (1) · David Kaplan, MD (1) · Edward Lain, MD (1) · Francisco Flores, MD (1) · George Murakawa, MD (1) · Ian Landells, MD (1)
PMID 19746769, PMID 24934963, PMID 26897386, PMID 27177989, PMID 27514932, PMID 28573779, PMID 29369333, PMID 29537444, PMID 31251543