231 completed, 66 recruiting, 43 unknown, 21 terminated. 401 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 401 | Completed 231, Recruiting 66, Unknown 43, Terminated 21, Not yet recruiting 17, Active not recruiting 13, Enrolling by invitation 7, Withdrawn 2, Suspended 1 |
Follow Abnormalities, Multiple: new trials by email Literature Review of Abnormalities, Multiple trials Research Report on Abnormalities, Multiple
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation Regulating Together group therapy - Prader-Willi Syndrome | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 10 | 2027-01-01 | 2026-09-02 |
| Creating Mobility-supported Home Play Environments to Enhance Development in Infants With Down Syndrome PUMA - Down Syndrome | Not applicable | Not yet recruiting | Boston University Charles River Campus | 60 | 2027-01-01 | 2026-11-13 |
| Executive Function Play Opportunities for Children With Down Syndrome EXPO, EXPO Extended, EXPO Foundations - Down Syndrome, Trisomy 21 | Not applicable | Not yet recruiting | Colorado State University | 150 | 2026-12-01 | 2026-10-30 |
| Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA - Obstructive Sleep Apnea, Down Syndrome (Trisomy 21) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 50 | 2026-11-02 | 2026-10-07 |
| Single Session Support for Parents of Children With Neurodevelopmental Disabilities Struggling With Anxious Avoidance EMPOWER-ND - Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD) | Not applicable | Not yet recruiting | Boston University Charles River Campus | 50 | 2026-11-01 | 2026-10-27 |
| SENSE-Brain Health Pro for Older Adults With Sensory Loss Brain Health Pro - Vision and Hearing Loss, Vision Impairment | Not applicable | Not yet recruiting | Université de Montréal | 300 | 2026-10-15 | 2026-10-05 |
| Dietary Modulation of Urinary MCP-1 in ADPKD Carbohydrate Restricted, Plant Dominant Diet, usual diet - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Not applicable | Enrolling by invitation | Assaf-Harofeh Medical Center | 36 | 2026-09-17 | 2026-11-12 |
| Vestibular Stimulation Versus Foot Intrinsic Muscle Exercises in Children With Down Syndrome Vestibular Stimulation Exercises, Foot Intrinsic Muscle Exercises - Down Syndrome, Balance Impairment | Not applicable | Not yet recruiting | Shalamar Institute of Health Sciences | 48 | 2026-09-02 | 2026-08-21 |
| Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome suspension walker - Down Syndrome | Not applicable | Not yet recruiting | University of Southern California | 12 | 2026-09-01 | 2026-06-05 |
| Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language Impairment Syntactic-Semantic Visual Configuration Intervention (SSVCI) - Language Impairment, Autism | Not applicable | Completed | Riphah International University | 20 | 2026-08-01 | 2026-11-05 |
| Clearance in Primary Ciliary Dyskinesia Exercise, HS pretreatment with Exercise - Primary Ciliary Dyskinesia, PCD | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 8 | 2026-07-30 | 2026-07-13 |
| Managing Depressive Symptoms in ADPKD Mayo Clinic-Approved Education, Digital Neuropathy, Capacity Coaching - Autosomal Dominant Polycystic Kidney Disease | Not applicable | Recruiting | Mayo Clinic | 105 | 2026-06-12 | 2026-08-07 |
| Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease Interventional Diet - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Not applicable | Not yet recruiting | Loma Linda University | 30 | 2026-05-01 | 2026-01-30 |
| Digital Physiotherapy for Pediatric Chronic Suppurative Lung Diseases Videoconferencing (Vsee platform), Specially designed website (FysΑΩ) - Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis | Not applicable | Not yet recruiting | University of Thessaly | 32 | 2026-05-01 | 2026-01-30 |
| 18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors 18F-T2 PET/CT - Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC) | Not applicable | Recruiting | Peking University First Hospital | 200 | 2026-04-27 | 2026-05-14 |
| HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome The HomeGrown, Waitlist - Down Syndrome, Child Obesity | Not applicable | Active not recruiting | UNC Lineberger Comprehensive Cancer Center | 38 | 2026-04-16 | 2026-09-03 |
| Developing Resource Interventions for Healthcare Professionals and Patients to Improve Knowledge About Fertility in Primary Ciliary Dyskinesia Online educational resource, Toolkit for healthcare professionals - Primary Ciliary Dyskinesia (PCD), Fertility | Not applicable | Not yet recruiting | University of Southampton | 30 | 2026-04-01 | 2026-04-15 |
| Animal Fun Program and Kinesthetic Development in Down Syndrome Animal fun program - Kinesthetic Illusion | Not applicable | Completed | Riphah International University | 25 | 2026-04-01 | 2026-09-30 |
| Adapting RDAD for DS Remote Exercise Sessions, Caregiver Education Sessions - Down Syndrome (DS), Alzheimer's Disease (AD) | Not applicable | Active not recruiting | University of Kansas Medical Center | 40 | 2026-03-31 | 2026-11-10 |
| Effects of Bubble Cushion Exercises on Postural Control in Children With Down Syndrome Bubble cushion exercises - Down Syndrome | Not applicable | Completed | Riphah International University | 22 | 2026-03-25 | 2026-08-11 |
Showing 20 of 401. Sign in to see all of them.
Down Syndrome (218) · Prader-Willi Syndrome (39) · Polycystic Kidney, Autosomal Dominant (36) · Ciliary Motility Disorders (19) · Intellectual Disability (18) · Sleep Apnea, Obstructive (16) · Marfan Syndrome (14) · Obesity (14) · DiGeorge Syndrome (12) · Motor Activity (12) · Autism Spectrum Disorder (11) · Cerebral Palsy (11) · Learning Disabilities (9) · Polycystic Kidney Diseases (9) · Autistic Disorder (7)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (401) · Congenital Abnormalities (398) · Genetic Diseases, Inborn (387) · Nervous System Diseases (286) · Chromosome Disorders (283) · Neurologic Manifestations (269) · Neurobehavioral Manifestations (263) · Intellectual Disability (244) · Pathological Conditions, Signs and Symptoms (80) · Nutritional and Metabolic Diseases (70) · Signs and Symptoms (70) · Ciliopathies (65) · Cardiovascular Diseases (57) · Female Urogenital Diseases and Pregnancy Complications (52)
Blood Specimen Collection (12) · Exercise (9) · Control Groups (5) · Diet, Ketogenic (4) · Equine-Assisted Therapy (4) · Diet (3) · Exenatide (3) · Neuropsychological Tests (3) · Transcranial Direct Current Stimulation (3) · Waiting Lists (3) · Actigraphy (2) · Activator Appliances (2) · Biopsy (2) · Continuous Positive Airway Pressure (2) · Drug Delivery Systems (2)
Riphah International University (47) · Assistance Publique - Hôpitaux de Paris (12) · Cairo University (10) · University of Kansas Medical Center (9) · University Hospital, Toulouse (8) · Oregon Health and Science University (7) · Hôpital le Vinatier (6) · Institut Jerome Lejeune (6) · University of Colorado, Denver (6) · Duke University (5) · Stanford University (5) · University of Michigan (5) · Indiana University (4) · University of Sao Paulo (4) · University of Seville (4)
United States (148) · Pakistan (49) · France (48) · Turkey (Türkiye) (17) · Egypt (15) · Spain (15) · Italy (11) · Canada (8) · Denmark (7) · Switzerland (7) · United Kingdom (7) · China (6) · Belgium (5) · Germany (5) · Netherlands (5)
Chiara Leoni, MD, PhD (3) · Amy Bodde, PhD (2) · Andrea M Haqq, MD (2) · Binash Afzal, PHD* (2) · Brian Chicoine, MD (2) · Carles Lerin, PhD (2) · Christoph Stettler, Prof. MD (2) · Mary Norton, MD (2) · Michael Freemark, MD (2) · Seda Tierney, MD (2) · Stephan Eliez, Professor (2) · Thessa Hilgenkamp, PhD (2) · William T Cade, PT, PhD (2)
PMID 39356039, PMID 35396980, PMID 37729939, PMID 10586155, PMID 12183720, PMID 12520259, PMID 12889762, PMID 16509530, PMID 17344250, PMID 17804777, PMID 18296460, PMID 19104360, PMID 19141364, PMID 20075148, PMID 20097432, PMID 20673078, PMID 20876670, PMID 20927000, PMID 21352207, PMID 21354816, PMID 22002941, PMID 22113127, PMID 22247403, PMID 22940168, PMID 23436915, PMID 23711443, PMID 23732715, PMID 23787357, PMID 23968742, PMID 24207068, PMID 24360789, PMID 24529259, PMID 24831720, PMID 24955611, PMID 25124699, PMID 25491305, PMID 25595400, PMID 25626035, PMID 26044111, PMID 26199618, PMID 26259133, PMID 26585432, PMID 26604914, PMID 26811129, PMID 27071367, PMID 27146407, PMID 27222591, PMID 27244805, PMID 27295193, PMID 27459537
R61HL151253 (2), 2016 (1), 2017 (1), 3KL2TR002367-08S1 (1), 5TL1TR002318-07 (1), K12HD043494 (1), K12HD055931 (1), K23RR021979 (1), K99HD092606 (1), KL2TR002367 (1), P30CA124435 (1), P30DK048520 (1), R00HD092606 (1), R01AG063909 (1), R01AG076678 (1)