75 completed, 34 unknown, 21 recruiting, 9 active not recruiting. 65 Not applicable, 18 Phase 3, 16 Phase 2, 11 Phase 4, 6 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Focal Versus Whole Gland High Dose-Rate Brachytherapy (HDR-BT) Boost to External Beam Radiotherapy in Localized Prostate Cancer: A Phase 2 Randomized Trial Standard Arm: Whole Gland High Dose Rate Brachytherapy Boost, Experimental Arm: Focal High Dose Rate Brachytherapy Boost - Prostate Cancer | Not applicable | Recruiting | Joelle Helou | 58 | 2026-06-10 | 2026-10-05 |
| Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction Xo Port Organ Preservation System, Standard of Care - Ice packs - Primary Graft Dysfunction | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2026-04-17 | 2026-07-13 |
| The PAPYRUS Study: Permanent vs. Absorbable Sutures in PrimarY Repair of Umbilical HerniaS: A Multicentre, Single-blind, Non-inferiority, Randomized Controlled Trial Permanent Suture, Absorbable - Hernia Surgery, Umbilical Hernia Repair | Not applicable | Not yet recruiting | University of British Columbia | 914 | 2026-01-01 | 2025-09-30 |
| Oral Sodium Bicarbonate for the Prevention of Labour Dystocia oral sodium bicarbonate - Labour Dystocia | Not applicable | Not yet recruiting | Liz Darling | 200 | 2025-12-01 | 2025-07-23 |
| Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus Radiation Therapy Followed by Surgery for Resectable Hepatocellular Carcinoma. Chemotherapy/Radiation - Hepatocellular Carcinoma (HCC) | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 30 | 2025-11-07 | 2026-09-17 |
| Feasibility Study of Novice-Performed Lung Ultrasound for Pneumothorax Detection After Cardiac Surgery Pneumothorax, Cardiac Surgery | Recruiting | Jacobo Moreno Garijo | 120 | 2025-09-16 | 2025-12-24 | |
| DIALysis With EXpanded Solute Removal Super High-Flux Dialyzer, High-Flux Dialyzer - Chronic Kidney Disease Requiring Hemodialysis, End-Stage Kidney Disease (ESKD) | Not applicable | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 4800 | 2025-08-12 | 2026-09-24 |
| Genomic First Testing in Chronic Kidney Disease Genetic Testing - Chronic Kidney Disease(CKD), Genetic Kidney Disease | Not yet recruiting | Dervla Connaughton | 2400 | 2025-03-01 | 2025-01-27 | |
| Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps Prophylactic defect closure, No prophylactic defect closure - Colorectal Cancer, Polyp of Colon | Not applicable | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 686 | 2025-02-27 | 2026-09-08 |
| Best Practices Fo Early Diagnosis of Cerebral Palsy Implementation group, Standard of care - Cerebral Palsy, Prematurity | Not applicable | Not yet recruiting | St. Justine's Hospital | 2000 | 2025-02-01 | 2024-12-18 |
| Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease N-Acetyl cysteine, Dexamethasone Oral, N-Acetyl cysteine Placebo - Lung Cancer, Interstitial Lung Disease | Phase 2 | Recruiting | David Palma | 98 | 2025-01-07 | 2026-08-26 |
| Therapeutic Normothermia in TBI Therapeutic Normothermia Group - Traumatic Brain Injury | Not applicable | Not yet recruiting | London Health Sciences Centre | 50 | 2025-01-01 | 2024-12-16 |
| SWiFT Canada (Study of Whole Blood in Frontline Trauma) Whole Blood, RBC + plasma - Trauma | Not applicable | Recruiting | Unity Health Toronto | 60 | 2024-12-16 | 2026-05-06 |
| Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock Venous Excess Ultrasound (VEXUS)-Guided Management - Septic Shock, Sepsis | Phase 3 | Not yet recruiting | Western University, Canada | 80 | 2024-12-01 | 2024-11-20 |
| Use of 81 vs 325mg of ASA in Treatment of BCVI Acetylsalicylic Acid - Carotid Artery Injuries, Traumatic Injury | Early Phase 1 | Unknown | London Health Sciences Centre | 40 | 2024-06-01 | 2024-04-25 |
| Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective Cardiovascular Surgical Procedures, Albumin | Active not recruiting | University Health Network, Toronto | 505 | 2024-05-23 | 2026-06-25 | |
| Early Severe Illness TrAnslational BioLogy InformaticS in Humans Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate - Sepsis, ARDS | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1000 | 2024-04-26 | 2025-10-06 | |
| Prediction of Intraventricular Hemorrhage Using Echocardiography and Near Infrared Spectroscopy Cerebral near-infrared spectroscopy, Functional echocardiography, Head Ultrasound - Intraventricular Hemorrhage of Newborn Grade 2, Intraventricular Hemorrhage of Newborn Grade 3 | Recruiting | Mount Sinai Hospital, Canada | 380 | 2024-04-22 | 2025-03-24 | |
| Propranolol for the Treatment of Traumatic Brain Injury Propranolol, Placebo - TBI (Traumatic Brain Injury) | Early Phase 1 | Unknown | London Health Sciences Centre | 50 | 2024-03-01 | 2024-02-15 |
| Shared Decision Making in Paediatric Inflammatory Bowel Disease Decision Coach Sessions - Inflammatory Bowel Diseases, Crohn Disease | Not applicable | Unknown | London Health Sciences Centre | 150 | 2024-01-01 | 2023-12-11 |
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Atrial Fibrillation (5) · Neoplasms (5) · Breast Neoplasms (4) · Coronary Artery Disease (4) · Multiple Sclerosis (4) · Prostatic Neoplasms (4) · Psychotic Disorders (4) · Sepsis (4) · Shock (4) · Shock, Septic (4) · Wounds and Injuries (4) · Carcinoma, Hepatocellular (3) · Cognitive Dysfunction (3) · Critical Illness (3) · Delirium (3)
Saline Solution (3) · Surveys and Questionnaires (3) · Acetaminophen (2) · Adrenal Cortex Hormones (2) · Dexamethasone (2) · Drug Therapy (2) · Hematologic Tests (2) · Magnetic Resonance Spectroscopy (2) · Metformin (2) · Plasma Exchange (2) · Respiratory Function Tests (2) · Tomography, X-Ray Computed (2) · 3-hydroxy-3-methylglutaryl-coenzyme A (1) · 4-Aminopyridine (1) · Acetylcysteine (1)
Canada (135) · United States (10) · Australia (2) · Belgium (2) · Israel (2) · Italy (2) · United Kingdom (2) · Brazil (1) · Chile (1) · China (1) · Germany (1) · India (1) · Ireland (1) · Japan (1) · Jordan (1)
Grace E Parraga, PhD (6) · David Palma, MD (3) · Arlene MacDougall, M.Sc., M.D. (2) · Barbara J Fisher, MD (2) · Dave Nagpal, MD (2) · David G McCormack, MD (2) · Greg Knoll, MD (2) · Jaime Guzman, MD, FRCPC (2) · Jonathan Izawa, MD (2) · Timothy P Turkstra, MD (2) · Vivian McAlister (2) · Adam Huber, MD (1) · Adam Power, MD (1) · Alan Barkun, MD (1) · Aleks Leligdowicz, MD PhD (1)
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2025 (1), R01HD101528 (1)