7 completed, 4 terminated, 3 withdrawn, 1 active not recruiting. 15 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 7, Terminated 4, Withdrawn 3, Active not recruiting 1 |
| Phase 1 | 3 | Completed 2, Withdrawn 1 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Zonisamide: new trials by email Literature Review of Zonisamide trials Research Report on Zonisamide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study Zonisamide, Placebo - Alcohol Use Disorder (AUD) | Phase 2 | Active not recruiting | Washington State University | 205 | 2022-01-07 | 2026-07-06 |
| Noise-Induced Hearing Loss-Acute Exposure Treatment (UA) Zonisamide 100Mg Cap, Placebo - Hearing Loss, Noise-Induced | Phase 2 | Terminated | Washington University School of Medicine | 3 | 2021-11-10 | 2026-02-13 |
| Noise-Induced Hearing Loss-Acute Exposure Treatment Zonisamide 100Mg Cap, Placebo - Hearing Loss, Noise-Induced | Phase 2 | Terminated | Washington University School of Medicine | 24 | 2021-10-04 | 2025-01-15 |
| Zonisamide Outpatient Study Zonisamide, Placebo Comparator - Post Traumatic Stress Disorder, Alcohol Use Disorder | Phase 2 | Withdrawn | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance | 2019-03-01 | 2021-03-09 | |
| Prevention of Noise-induced Hearing Loss Zonisamide, Methylprednisolone - Noise-induced Hearing Loss | Phase 1 / Phase 2 | Withdrawn | Washington University School of Medicine | 2017-10-31 | 2017-11-06 | |
| Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence Enhanced-Cognitive Processing Therapy-C (E-CPT-C), Zonisamide, Placebo - Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD) | Phase 2 | Completed | Yale University | 24 | 2013-06-01 | 2020-03-16 |
| Study of Zonisamide in Early Parkinson Disease Zonisamide, Placebo - Parkinson Disease | Phase 2 / Phase 3 | Withdrawn | Mazandaran University of Medical Sciences | 2013-02-01 | 2022-04-14 | |
| Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation zonisamide, placebo - Nicotine Dependence | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 74 | 2012-09-01 | 2018-01-24 |
| Zonisamide for Heavy Drinkers With Bipolar Disorder Zonisamide, Placebo - Alcohol Use Disorders, Bipolar Disorder | Phase 2 | Terminated | Yale University | 3 | 2012-05-01 | 2017-01-13 |
| Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse Zonisamide, Placebo, Cocaine Hydrochloride - Cocaine Dependence | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 19 | 2010-06-01 | 2017-09-05 |
| Zonisamide for the Treatment of Obstructive Sleep Apnea in Overweight/Obese Patients Zonisamide, Placebo, nCPAP - Sleep Apnea, Obstructive Sleep Apnea | Phase 2 | Completed | Göteborg University | 50 | 2010-03-01 | 2014-02-20 |
| Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism Topiramate, Zonisamide, Levetiracetam - Alcoholism, Alcohol Dependence | Phase 2 | Terminated | Boston Medical Center | 85 | 2009-05-01 | 2015-04-28 |
| The Effects of Zonisamide on Alcohol Dependence Zonisamide - Alcoholism | Phase 2 | Completed | Boston University | 16 | 2006-11-01 | 2010-05-11 |
| A Safety/Efficacy Trial of Zonisamide for Essential Tremor Zonisamide - Essential Tremor | Phase 2 | Completed | VA Greater Los Angeles Healthcare System | 25 | 2004-11-01 | 2012-06-22 |
| A Study to Measure the Safety and Effectiveness of Zonisamide in Subjects With Migraine Headache zonisamide - Migraine Headache | Phase 2 | Completed | Elan Pharmaceuticals | 204 | 2002-03-01 | 2015-12-14 |
Alcoholism (6) · Hearing Loss, Noise-Induced (3) · Stress Disorders, Post-Traumatic (2) · Substance-Related Disorders (2) · Alcohol Drinking (1) · Alcoholic Intoxication (1) · Apnea (1) · Behavior, Addictive (1) · Bipolar Disorder (1) · Cocaine-Related Disorders (1) · Essential Tremor (1) · Hearing Loss (1) · Migraine Disorders (1) · Obesity (1) · Parkinson Disease (1)
Washington University School of Medicine (3) · Johns Hopkins University (2) · Yale University (2) · Boston Medical Center (1) · Boston University (1) · Elan Pharmaceuticals (1) · Göteborg University (1) · Mazandaran University of Medical Sciences (1) · Pharmacotherapies for Alcohol and Substance Use Disorders Alliance (1) · VA Greater Los Angeles Healthcare System (1) · Washington State University (1)
United States (13) · Sweden (1)
Annie Umbricht, M.D. (2) · Craig A Buchman, MD, FACS (2) · Adrian Handforth, M.D. (1) · Albert J Arias, MD (1) · Clifford Knapp, PhD (1) · Domenic A Ciraulo, MD (1) · Ismene Petrakis, M.D. (1) · Jan Hedner, MD. Prof. (1) · Judith Lieu, MD (1) · Masoud Etemadifar (1)
2009 (1), K23AA017689 (1), P60AA013759 (1), R01AA015923 (1), R01DA027065 (1), R21DA034164 (1)