13 completed, 5 unknown, 2 terminated. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 13, Unknown 5, Terminated 2 |
Follow Vitamin B 12: new trials by email Literature Review of Vitamin B 12 trials Research Report on Vitamin B 12
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin B12 Absorption Study Ampli-B, Vitamin B12 - Healthy Volunteers | Phase 4 | Completed | RDC Clinical Pty Ltd | 12 | 2026-07-20 | 2026-09-09 |
| A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth Vitamin B12, Vitamin B6, Folic acid, Vitamin B12 (Cyanocobalamin) - Vitamin B12 Deficiency | Phase 4 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 46 | 2025-04-16 | 2026-09-04 |
| Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo Gamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin, Ginger - Vertigo | Phase 4 | Completed | Fundação Educacional Serra dos Órgãos | 334 | 2021-11-22 | 2023-05-17 |
| Management of Preoperative Anaemia in Surgical Oncology Ferric Carboxymaltose Injection, Folic acid, B12 - Anemia, Tumor | Phase 4 | Unknown | Azienda Ospedaliera Universitaria Integrata Verona | 500 | 2021-03-02 | 2022-08-19 |
| GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response Cyanocobalamin, Dulaglutide - Glucose Intolerance, Overweight and Obesity | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 23 | 2020-05-15 | 2024-12-05 |
| Intracoronary Administration of Levosimendan in Cardiac Surgery Patients levosimendan, Vitamin B 12 - Myocardial Stunning | Phase 4 | Terminated | Tampere University Hospital | 50 | 2018-06-15 | 2019-09-13 |
| Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy Injection Mecobalamin,, Tablet Pyridoxine hydrochloride, Intravenous normal saline 1 ml - Vincristine Induced Peripheral Neuropathy (VIPN) | Phase 4 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 88 | 2016-10-01 | 2019-11-08 |
| Nucleotides and B Vitamins in the Treatment of Low Back Pain Nucleotides + B12, B Vitamins - Low Back Pain | Phase 4 | Completed | Fundação Educacional Serra dos Órgãos | 300 | 2016-03-01 | 2019-04-19 |
| A Trial of Folate With B12 in Patients With Schizophrenia With Residual Symptoms in Ethiopia folate with B12, placebo - Schizophrenia | Phase 4 | Completed | Massachusetts General Hospital | 200 | 2014-12-01 | 2018-08-15 |
| Vitamin D and Vitamin B12 Supplementation With Pegylated Interferon-Alfa Plus Ribavirin for Treating Chronic Hepatitis C Vitamin D, Vitamin B 12 - RNA Virus Infections, Flaviviridae Infections | Phase 4 | Terminated | Federal University of São Paulo | 85 | 2014-03-01 | 2016-08-24 |
| Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy Folic Acid, vit B6 and B12, Placebo - Non Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy | Phase 4 | Unknown | University of Catania | 160 | 2012-09-01 | 2013-08-13 |
| Vitamin B12 Pregnancy Supplementation vitamin b12 - Pregnancy Anemia | Phase 4 | Completed | Mirela Zec | 200 | 2011-09-15 | 2018-05-11 |
| Vitamin B12 Supplement to Prevent Cognitive Decline Vitamin B12, Placebo - Cognitive Decline | Phase 4 | Completed | Chinese University of Hong Kong | 271 | 2011-08-01 | 2016-01-28 |
| Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial Tenavit®, Placebo Oral Tablet - Menopause, Dyslipidemias | Phase 4 | Completed | Casa de Saúde santa Marcelina | 60 | 2008-12-01 | 2017-07-21 |
| Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia Folic Acid, B12, Placebo - Schizophrenia | Phase 4 | Completed | Massachusetts General Hospital | 140 | 2007-12-01 | 2014-08-19 |
| How Many Patients Are in Need of Vitamin B12 Injections? vitamin B12 - Vitamin B12 Deficiency | Phase 4 | Unknown | University of Aarhus | 50 | 2006-01-01 | 2008-08-08 |
| Can Oral Vitamin B12 and Folate Supplementation Preserve Cognitive Function of Patients With Early Dementia? Vitamin B12, folate - Dementia | Phase 4 | Completed | Chinese University of Hong Kong | 166 | 2004-10-01 | 2009-02-03 |
| Homocysteine Lowering and Atherosclerosis Reduction Trial (HART) Vitamins: Folic acid, B6, B12 - Atherosclerosis, Cardiovascular Disease | Phase 4 | Unknown | Hamilton Health Sciences Corporation | 900 | 2000-01-01 | 2005-09-22 |
| HOPE-2 Study (Heart Outcomes Prevention Evaluation-2 Study) Folic acid, vitamin B6 and B12 or placebo - Cardiovascular Disease, Myocardial Infarction | Phase 4 | Unknown | Hamilton Health Sciences Corporation | 5000 | 1999-12-01 | 2005-09-20 |
| Myo-inositol Versus D-chiro-inositol in the Treatment of Polycystic Ovary Syndrome and Insulin Resistance: Evaluation of Clinical, Metabolic, Endocrine and Ultrasound Parameters Myo-inositol + Folic acid, D-chiro-inositol, manganese, folic acid, vit B12, Folic acid, vit B12 - PCOS | Phase 4 | Completed | AGUNCO Obstetrics and Gynecology Centre | 2012-01-23 |
Anemia (2) · Cardiovascular Diseases (2) · Neoplasms (2) · Schizophrenia (2) · Vitamin B 12 Deficiency (2) · Atherosclerosis (1) · Cognitive Dysfunction (1) · Dementia (1) · Dyslipidemias (1) · Flaviviridae Infections (1) · Glucose Intolerance (1) · Hepatitis C (1) · Hepatitis C, Chronic (1) · Insulin Resistance (1) · Low Back Pain (1)
Chinese University of Hong Kong (2) · Fundação Educacional Serra dos Órgãos (2) · Hamilton Health Sciences Corporation (2) · Massachusetts General Hospital (2) · AGUNCO Obstetrics and Gynecology Centre (1) · Azienda Ospedaliera Universitaria Integrata Verona (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Casa de Saúde santa Marcelina (1) · Federal University of São Paulo (1) · Medice Arzneimittel Pütter GmbH & Co KG (1) · Mirela Zec (1) · RDC Clinical Pty Ltd (1) · Tampere University Hospital (1) · The University of Texas Health Science Center, Houston (1) · University of Aarhus (1)
Italy (3) · Brazil (2) · Canada (2) · China (2) · United States (2) · Australia (1) · Bangladesh (1) · Denmark (1) · Ethiopia (1) · Finland (1) · Ukraine (1)
Eva M Lonn, MD MSc FRCPC FACC (2) · Absalon D Gutierrez, MD (1) · Adauto Castelo, PhD (1) · Alexandros Kanellopoulos (1) · Anne-Mette Hvas, MD, PhD (1) · Damir Roje, Prof. (1) · Donald Goff, MD (1) · Gregory Fricchione, MD (1) · Jorge F Senise, PhD (1) · Marco AN Mibielli, MD (1) · Panu Virkkala, MD (1) · Timothy CY Kwok, MD (1)
PMID 18940900, PMID 10069782, PMID 10367822, PMID 10529901, PMID 10793599, PMID 10946791, PMID 11339434, PMID 16531613, PMID 17470822, PMID 17954810, PMID 18003666, PMID 18070815, PMID 19228852, PMID 21623649, PMID 21864249, PMID 21877144, PMID 23467813, PMID 24438922, PMID 27823800, PMID 3537898, PMID 8123652, PMID 8133587, PMID 8839504
R01MH070831 (1), R21DK122234 (1)