5 completed, 1 not yet recruiting, 1 recruiting, 1 unknown. 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 5, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow tizanidine: new trials by email Literature Review of tizanidine trials Research Report on tizanidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial Tizanidine, MI-Opioid Taper, Placebo - Chronic Pain, Back Pain | Phase 3 | Recruiting | Stanford University | 375 | 2024-12-05 | 2026-05-06 |
| Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm Etoricoxib + Tizanidine fixed dose, Etoricoxib fixed dose - Acute Low-back Pain, Muscle Spasm; Back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 136 | 2024-09-18 | 2026-01-09 |
| Effect of Tizanidine on Postoperative Urinary Retention After Sacrospinous Suspension Tizanidine - Postoperative Urinary Retention, Sacrospinous Vaginal Vault Suspension | Phase 3 | Completed | Endeavor Health | 20 | 2024-09-17 | 2025-11-24 |
| TIzanidine for the Preventive Treatment of Episodic MigrainE （TIME） Tizanidine Hydrochloride, Tizanidine Hydrochloride Placebo - Migraine Without Aura, Migraine With Aura | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 189 | 2023-06-01 | 2024-08-01 |
| Study to Assess the Efficacy and Safety of Tizaspray® Versus Sirdalud®, in Patients With Acute Low Back Pain Tizaspray® administered intranasally, Sirdalud® 2 mg tablets administered - Low Back Pain | Phase 3 | Completed | MDM S.p.A. | 117 | 2016-10-01 | 2018-01-16 |
| Safety and Efficacy of Neuromultivit in Treatment of Vertebrogenic Radiculopathy Neuromultivit, Voltaren, Sirdalud - Vertebrogenic Radiculopathy L5, S1 | Phase 3 | Completed | Bausch Health Americas, Inc. | 100 | 2015-05-01 | 2017-05-09 |
| Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity. tizanidine hydrochloride capsule - Multiple Sclerosis, Muscle Spasticity | Phase 3 | Completed | Elan Pharmaceuticals | 120 | 2002-06-01 | 2015-12-14 |
Back Pain (2) · Chronic Pain (1) · Low Back Pain (1) · Migraine Disorders (1) · Migraine with Aura (1) · Migraine without Aura (1) · Multiple Sclerosis (1) · Muscle Spasticity (1) · Neck Pain (1) · Opioid-Related Disorders (1) · Pain (1) · Pain, Postoperative (1) · Spasm (1) · Spinal Cord Injuries (1) · Stroke (1)
Bausch Health Americas, Inc. (1) · Elan Pharmaceuticals (1) · Endeavor Health (1) · Laboratorios Silanes S.A. de C.V. (1) · MDM S.p.A. (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Stanford University (1) · University of California, San Francisco (1)
United States (4) · China (1) · Mexico (1) · Romania (1) · Russia (1)
Andrew Bishara, MD (1) · Claudia Paya Ten, MD (1) · Doina Rosu, MD (1) · Farit Khabirov, MD, DSc, Prof (1) · Kaiming Liu, MD & PHD (1) · Lilia E Acevedo-Rojas, MD (1) · Mauricio Flores-Araujo, MD (1) · Salvador Perez-Jaime, MD (1)
PMID 22590713, PMID 23731663, PMID 24524844, PMID 30353868, PMID 30496104, PMID 30879893, PMID 32430657