12 completed, 2 recruiting, 2 terminated, 2 unknown. 19 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 12, Recruiting 2, Terminated 2, Unknown 2, Not yet recruiting 1 |
| Phase 2 | 3 | Completed 1, Not yet recruiting 1, Unknown 1 |
Follow Sodium Bicarbonate: new trials by email Literature Review of Sodium Bicarbonate trials Research Report on Sodium Bicarbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones Potassium Citrate, Sodium Bicarbonate - Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis | Phase 1 / Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2026-02-01 | 2026-02-12 |
| Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers Potassium citrate, Sodium bicarbonate - Uric Acid Stones | Phase 1 | Recruiting | University of California, Irvine | 100 | 2025-05-01 | 2025-06-24 |
| Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial Buffered Lidocaine (1% Lidocaine + 8.4% Sodium Bicarbonate, in a 3:1 ratio), Lidocaine, Biopsy of Prostate - Prostate Cancer | Phase 1 / Phase 2 | Completed | University of Washington | 350 | 2025-01-09 | 2026-02-17 |
| A Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril Captopril 12.5 Mg, Sodium bicarbonate 4 G, Torsemide 20 MG - Hypertension | Phase 1 | Completed | Seoul National University Hospital | 12 | 2024-02-28 | 2025-05-30 |
| A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants Orforglipron, Simvastatin, Digoxin - Healthy, Obese | Phase 1 | Completed | Eli Lilly and Company | 50 | 2024-01-02 | 2026-05-22 |
| the Effect of Interdialytic Serum Bicarbonate Correction on Vascular Calcification in Hemodialysis Patients Oral sodium bicarbonate - End Stage Renal Disease (ESRD), Metabolic Acidosis | Phase 1 | Completed | Ain Shams University | 40 | 2023-09-01 | 2026-08-14 |
| Sympatholysis in Chronic Kidney Disease Sodium Bicarbonate, Placebo, Exercise Training - Chronic Kidney Disease | Phase 1 | Recruiting | Emory University | 110 | 2015-06-11 | 2026-05-18 |
| Acid-Base Compensation in Chronic Kidney Disease Sodium bicarbonate, Controlled diet - Chronic Kidney Disease | Phase 1 | Completed | Duke University | 14 | 2015-04-01 | 2017-08-30 |
| Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis hypertonic bicarbonate, sodium chloride - Cystic Fibrosis | Phase 1 | Completed | Joseph Pilewski | 12 | 2014-08-01 | 2018-01-05 |
| The Effect of Antacids and Multivitamins on Raltegravir Multivitamins, Sodium bicarbonate, Maalox Plus extra - HIV | Phase 1 | Completed | Helen Reynolds | 15 | 2014-04-01 | 2026-08-17 |
| The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline C/S plus minocycline., nebulization with pH 7.4 solution, nebulization with pH 7.8 solution - Pneumonia | Phase 1 / Phase 2 | Unknown | Xijing Hospital | 90 | 2014-03-01 | 2014-02-11 |
| Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain Sodium Bicarbonate - Tumor, Cancer | Phase 1 | Terminated | H. Lee Moffitt Cancer Center and Research Institute | 9 | 2013-09-01 | 2015-06-04 |
| Extended Use of Sodium Bicarbonate in Patients With Cancer Sodium Bicarbonate - Malignant Neoplasm | Phase 1 | Completed | University of Arizona | 15 | 2013-08-01 | 2016-04-13 |
| Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease Sodium Bicarbonate - Sickle Cell Anemia, Chronic Kidney Disease | Phase 1 | Terminated | University Hospitals Cleveland Medical Center | 7 | 2013-06-01 | 2019-03-20 |
| The Effects of Urinary pH Changes on an Investigational Compound in Healthy Subjects Ammonium Chloride + LY2140023, Sodium Bicarbonate + LY2140023, LY2140023 - Healthy Subjects | Phase 1 | Completed | Denovo Biopharma LLC | 29 | 2011-09-01 | 2026-09-15 |
| Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Anesthetized Children Sodium bicarbonate, normal saline - General Anesthesia | Phase 1 | Unknown | Sheba Medical Center | 30 | 2010-10-01 | 2010-10-28 |
| Gem-TABS in Unresectable Pancreatic Carcinoma Sodium bicarbonate (g/kg/day), Gemcitabine (mg/m²) - Pancreatic Cancer | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 8 | 2010-08-01 | 2017-02-23 |
| Safety and Immunogenicity of Peru-15-pCTB in Healthy Adult Subjects Ciprofloxacin, Peru-15-pCTB, Sodium bicarbonate/Ascorbic Acid/Aspartame Buffer - Gastroenteritis Escherichia Coli | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 62 | 2008-06-02 | 2021-07-29 |
| Inhaled Bicarbonate Therapy in Cystic Fibrosis sodium bicarbonate - Cystic Fibrosis | Phase 1 | Completed | University of Pittsburgh | 16 | 2002-03-01 | 2023-09-07 |
Renal Insufficiency, Chronic (3) · Acidosis (2) · Cystic Fibrosis (2) · Neoplasm Metastasis (2) · Neoplasms (2) · Adenocarcinoma (1) · Anemia, Sickle Cell (1) · Calculi (1) · Cancer Pain (1) · Cholera (1) · Diarrhea (1) · Escherichia coli Infections (1) · Hematologic Neoplasms (1) · Hypertension (1) · Kidney Calculi (1)
H. Lee Moffitt Cancer Center and Research Institute (2) · Ain Shams University (1) · Denovo Biopharma LLC (1) · Duke University (1) · Eli Lilly and Company (1) · Emory University (1) · Helen Reynolds (1) · Joseph Pilewski (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Seoul National University Hospital (1) · Sheba Medical Center (1) · University Hospitals Cleveland Medical Center (1) · University of Arizona (1) · University of California, Irvine (1) · University of California, Los Angeles (1)
United States (13) · United Kingdom (2) · Canada (1) · China (1) · Egypt (1) · Iceland (1) · Israel (1) · South Korea (1)
Alexander Zhu, DO (1) · Amit Mahipal, M.D. (1) · Gregory Springett, M.D., Ph.D. (1) · Ian Robey, PhD (1) · Jane Little, MD (1) · Jeanie Park, MD (1) · Joseph M PIlewski, MD (1) · Joseph M Pilewski, MD (1) · Julia Scialla (1) · Kymora B Scotland, MD, PhD (1) · Ralph V Clayman, MD (1) · Saye Khoo, Prof (1) · Sohrab N Ali, M.D (1)
PMID 36452492, PMID 25410205, PMID 33810868
K23DK095949 (1)