16 completed, 9 recruiting, 7 unknown, 2 not yet recruiting. 15 Not applicable, 8 Phase 2, 6 Phase 4, 4 Phase 1, 3 Phase 3.
Follow PPI: new trials by email Literature Review of PPI trials Research Report on PPI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vonoprazan High-Dose Dual VS Levofloxacin Concomitant Vonoprazan, Levofloxacin 500mg - Helicobacter Pylori Infection, Peptic Ulcer Disease | Phase 4 | Not yet recruiting | Damascus Hospital | 150 | 2026-11-01 | 2026-06-03 |
| Tegoprazan Versus Lansoprazole for Endoscopic Ulcer Healing in Bleeding Peptic Ulcers Tegoprazan tablet, Lansoprazole capsules - Peptic Ulcer Bleeding | Phase 2 | Recruiting | Universitas Indonesia | 162 | 2026-08-06 | 2026-08-21 |
| Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia Cases PPI, vitamin D, feeding instruction - Laryngomalacia | Not applicable | Recruiting | Minia University | 60 | 2026-04-28 | 2026-08-06 |
| Heartburn, Gastroesophageal Reflux Disease Zastaprazan, Esomeprazole - GERD | Phase 4 | Recruiting | Incheon St.Mary's Hospital | 160 | 2025-07-07 | 2025-12-23 |
| Tegoprazan And Lansoprazole Effectiveness in Bleeding Peptic Ulcer Treatment Tegoprazan, Lansoprazole - Peptic Ulcer Bleeding | Not applicable | Recruiting | Mario Steffanus | 162 | 2025-05-01 | 2025-05-29 |
| Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy Naproxen (Proxen S), Placebo, Esomeprazole 20mg once daily - Bone Pain Flare, Bone Metastasis | Phase 2 | Not yet recruiting | American University of Beirut Medical Center | 385 | 2025-04-01 | 2025-04-04 |
| Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration) - Roux-en-y Anastomosis Site, Marginal Ulcer | Not applicable | Recruiting | Christopher C. Thompson, MD, MSc | 100 | 2025-03-04 | 2026-06-25 |
| Efficacy of Nitazoxanide Based Therapy vs Standard Triple Therapy in H-pylori in Children Nitazoxanide, Metronidazole, PPI - Helicobacter Pylori Infection | Not applicable | Completed | Muhammad Aamir Latif | 66 | 2025-01-01 | 2025-07-25 |
| Fexuprazan for Prevention of Upper Gastrointestinal Bleeding in High Bleeding Risk Patients Receiving Dual Antiplatelet Therapy Fexuprazan 40mg, Lansoprazole 30mg - Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD) | Not applicable | Recruiting | SUK MIN SEO | 200 | 2024-10-24 | 2026-10-19 |
| Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole Tegoprazan, Esomeprazole 40mg - Helicobacter Pylori Infection | Phase 4 | Unknown | Hospital General de México Dr. Eduardo Liceaga | 160 | 2024-04-19 | 2024-03-19 |
| GERD Infant Feeding Therapeutics Trial (GIFT Trial) Omeprazole, AR formula - GERD in Infants | Not applicable | Recruiting | Nationwide Children's Hospital | 369 | 2024-03-14 | 2026-06-23 |
| Shaeer's Vein Ligation-I: Internal Pudendal Vein Sub-Gluteal Ligation For Veno Occlusive Erectile Dysfunction Shaeer-I, PPI - Erectile Dysfunction | Not applicable | Unknown | Kasr El Aini Hospital | 60 | 2024-01-01 | 2023-11-08 |
| Shaeer's Vein Ligation-II: Internal Pudendal Vein Perineal Ligation For Veno Occlusive Erectile Dysfunction Shaeer-II, PPI - Erectile Dysfunction, Erectile Dysfunction Due to Venous Disorder | Not applicable | Unknown | Kasr El Aini Hospital | 60 | 2024-01-01 | 2023-11-08 |
| A Study to Evaluate the Effect of Food, Formulation, and a Proton Pump Inhibitor (PPI) on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-003) Calderasib, PPI - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 56 | 2023-09-20 | 2026-02-11 |
| Emulation of Randomized Clinical Trial in Cardiovascular Disease PPI - Myocardial Infarction, Coronary Artery Disease | Unknown | Samsung Medical Center | 118420 | 2023-05-30 | 2024-03-26 | |
| Delirium Related to Proton Pump Inhibitors Use PPI - Proton Pump Inhibitor Adverse Reaction, Delirium | Completed | University Hospital, Caen | 19081 | 2022-02-09 | 2025-03-26 | |
| The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise NEAA, PPI - Metabolism, Exercise | Not applicable | Completed | University of Limerick | 33 | 2021-09-14 | 2022-06-22 |
| Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy PPI, P-CAB 50 - Coronary Artery Disease, Percutaneous Coronary Intervention | Phase 4 | Recruiting | Duk-Woo Park, MD | 3320 | 2021-05-12 | 2026-08-28 |
| Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial Placebo, Esomeprazole 20mg - Liver Cirrhosis | Phase 4 | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 476 | 2021-04-22 | 2025-04-24 |
| Dietary Supplement With and Without a Probiotic Complex oligosaccharide, Probiotic, PPI - Healthy Adult Subjects | Not applicable | Completed | Prolacta Bioscience | 62 | 2020-03-13 | 2025-03-18 |
Showing 20 of 37. Sign in to see all of them.
Gastroesophageal Reflux (10) · Peptic Ulcer (5) · Coronary Artery Disease (4) · Acute Coronary Syndrome (2) · Erectile Dysfunction (2) · Gastrointestinal Hemorrhage (2) · Heartburn (2) · Liver Cirrhosis (2) · Myocardial Infarction (2) · Peptic Ulcer Hemorrhage (2) · Abdominal Pain (1) · Barrett Esophagus (1) · Cough (1) · Cystic Fibrosis (1) · Deglutition Disorders (1)
Kasr El Aini Hospital (2) · American University of Beirut Medical Center (1) · Capital Medical University (1) · Children's Hospital of Philadelphia (1) · Christopher C. Thompson, MD, MSc (1) · Clinical Research Support Center Kyush (1) · Damascus Hospital (1) · Duk-Woo Park, MD (1) · EndoGastric Solutions (1) · Hospital General de México Dr. Eduardo Liceaga (1) · Incheon St.Mary's Hospital (1) · Ironwood Pharmaceuticals, Inc. (1) · Mario Steffanus (1) · Massachusetts Eye and Ear Infirmary (1) · Merck Sharp & Dohme LLC (1)
United States (11) · South Korea (6) · Egypt (3) · Germany (2) · Indonesia (2) · Taiwan (2) · Canada (1) · China (1) · France (1) · Ireland (1) · Japan (1) · Lebanon (1) · Pakistan (1) · Syria (1)
AiDong Wen, Pro (1) · Ansgar W Lohse, MD (1) · Bassem Youssef, MD (1) · Christopher C. Thompson, MD, MSc (1) · Christopher J Hartnick, MD (1) · Chuan Zhang, MD (1) · Hasan Maulahela, MD, PhD (1) · Heena Raees, FCPS (1) · Johannes Kluwe, MD (1) · Karim Trad, MD, FACS (1) · Ki Hong Choi, MD (1) · Lara Hilal, MD (1) · Lara Lane (1)
PMID 23721547, PMID 25284142, PMID 27289472, PMID 31977454, PMID 32092310, PMID 39414279, PMID 39962947, PMID 40188976, PMID 42277732
2018 (1), 2019 (1), 2023 (1), R01DK136762 (1)