120 completed, 11 unknown, 10 recruiting, 7 terminated. 59 Phase 2, 48 Phase 3, 36 Not applicable, 24 Phase 1, 14 Phase 4.
Follow Placebo Gel: new trials by email Literature Review of Placebo Gel trials Research Report on Placebo Gel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste Nano Bio-Fusion (NBF) Gingival Gel, Placebo Gel, Commercial fluoride toothpaste - Gingivitis, Healthy Adult | Not applicable | Not yet recruiting | King Abdullah University Hospital | 45 | 2026-10-01 | 2026-10-19 |
| Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis 2% Melatonin gel, Placebo Gel - Periodontal Diseases | Not applicable | Not yet recruiting | Alexandria University | 23 | 2026-09-10 | 2026-09-10 |
| Treatment of Recurrent Genital Warts by Combination of CO2 Laser and Geniwa Gel Geniwa gel, Placebo gel - HPV (Human Papillomavirus)-Associated, Genital Warts | Phase 2 | Recruiting | KTH Biopharma | 70 | 2026-07-16 | 2026-10-20 |
| Adjunctive Subgingival Pomegranate Peel Extract Gel for Stage II-III Periodontitis Pomegranate Peel Extract Gel, Placebo gel - Periodontitis | Not applicable | Recruiting | gehad samy | 32 | 2026-07-01 | 2026-07-24 |
| Biweekly Long-term Occidiofungin Study for Suppression of Mycotic Recurrence OCF001 Intravaginal Gel, Placebo Gel - Candidiasis, Vulvovaginal | Phase 2 | Recruiting | Sano Chemicals Inc | 36 | 2026-06-04 | 2026-06-15 |
| Effectiveness and Safety of a Hydrating Gel Containing Polyvinyl Pyrrolidine, Algin and Hyaluronic Acid Applied After and Without Fractional CO₂ Laser Therapy CO2 Fractional Laser, Hydrogel, Placebo gel - Hydration, Carbon-dioxide Laser | Not applicable | Not yet recruiting | Dr.dr.Irma Bernadette, SpKK (K) | 51 | 2026-06-01 | 2026-06-10 |
| FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL YASO GEL, Placebo gel - Early-phase Safety and PK Study of a Vaginal Gel | Early Phase 1 | Not yet recruiting | Yaso Therapeutics Corporation | 72 | 2026-04-01 | 2025-12-19 |
| Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN) VMD-3866 Gel, Placebo Gel - Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain | Phase 2 | Recruiting | VM Therapeutics LLC | 16 | 2025-12-12 | 2026-10-21 |
| COMPASS - COpenhagen MenoPAuSe Study Triptorelin 11.25 mg, Sodium Chloride 0.9%, Estradiol (E2) - Menopausal Osteoporosis, Bone Markers | Phase 2 | Recruiting | Martin Blomberg Jensen | 192 | 2025-10-02 | 2026-03-02 |
| Effect of a Probiotic Supplement on Gut Microbiota and Glycemic Control in Patients With Type 1 Diabetes (PRODIAB) Probiotic/Prebiotic Supplement, Placebo Gel - Diabete Type 1 | Not applicable | Not yet recruiting | Universidad Católica San Antonio de Murcia | 80 | 2025-09-01 | 2025-07-14 |
| Randomized, Triple-Blind, Vehicle-Controlled Trial of Topical Dapsone Gel 7.5% in Patients With Acne Vulgaris Dapsone 7.5% gel, Vehicle gel - Acne Vulgaris | Phase 4 | Completed | Oya Helin Dundar | 100 | 2025-06-17 | 2026-05-22 |
| Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation Chlorhexidine Gluconate Gel 1%, Chlorhexidine Gluconate 0.5% + Metronidazole 1.5% Gel, Placebo Gel - Plaque Induced Gingivitis | Not applicable | Completed | H.P. Government Dental College and Hospital Shimla | 120 | 2025-05-16 | 2026-08-21 |
| Brimonidine 0.33% for Rosacea-Related Facial Erythema Brimonidine 0.33% gel, Placebo gel - Rosacea, Rosacea Subtype 1 (Erythematotelangiectatic) | Phase 4 | Completed | Istanbul Training and Research Hospital | 45 | 2025-05-01 | 2026-02-24 |
| A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction ARC-001, Placebo gel - Acute Post Operative Pain, Third Molar Extraction Surgery | Early Phase 1 | Recruiting | Arcato Laboratories, Inc. | 30 | 2025-02-26 | 2025-03-11 |
| A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms AMZ001 Diclofenac gel, Placebo gel - Osteoarthritis of Knee, Osteoarthritis, Knee | Phase 3 | Completed | Amzell | 549 | 2025-02-18 | 2026-07-15 |
| Topical Diclofenac for Prevention of Radiation-induced Dermatitis Diclofenac Sodium Gel, Placebo gel - Head and Neck Tumor, Breast Cancer | Not applicable | Recruiting | The Second Affiliated Hospital of Hainan Medical University | 156 | 2025-02-13 | 2026-04-03 |
| A Clinical Trial to Compare the Photoprotective Effects of Cucumber Seed Extract vs Placebo in Filipino Adults by Measurement of Minimal Erythema Dose Placebo gel, 2% cucumber seed gel, 4% cucumber seed gel - Healthy Human Volunteers With Fitzpatrick Skin Type III-V, Sunburn, Erythema | Not applicable | Completed | DOH - Tondo Medical Center | 29 | 2025-01-27 | 2026-07-31 |
| Palatal Mucosa Wound Healing Following Antimicrobial Gel Application Gel containing postbiotics, lactoferrin, aloe barbadensis leaf juice powder and sodium hyaluronate, Placebo gel - Wound Healing, Palate; Wound | Not applicable | Active not recruiting | University of Roma La Sapienza | 13 | 2024-12-22 | 2025-04-23 |
| Effects of Enamel Matrix Derivative in the Treatment of Peri-implant Mucositis Placebo gel, Enamel Matrix Proteins Derivative - Mucositis, Peri Implant Mucositis | Not applicable | Enrolling by invitation | University of Catania | 54 | 2024-12-05 | 2025-06-04 |
| "Comparison of Spirulina Gels for Treating Stage II Grade B Periodontitis" Placebo gel, Spirulina Gel, Spirulina Nanoparticles Gel - Periodontitis Stage II | Not applicable | Enrolling by invitation | Kafrelsheikh University | 15 | 2024-10-21 | 2025-02-11 |
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Pain (11) · Hypogonadism (9) · Chronic Periodontitis (8) · Dentin Sensitivity (6) · HIV Infections (6) · Periodontitis (5) · Wounds and Injuries (5) · Inflammation (4) · Keratosis, Actinic (4) · Osteoarthritis, Knee (4) · Periodontal Diseases (4) · Rosacea (4) · Sexual Dysfunctions, Psychological (4) · Vaginosis, Bacterial (4) · Acne Vulgaris (3)
Government Dental College and Research Institute, Bangalore (6) · Starpharma Pty Ltd (5) · BioSante Pharmaceuticals (4) · National Institute of Allergy and Infectious Diseases (NIAID) (4) · Padagis LLC (4) · University of Washington (4) · Bayer (3) · Kafrelsheikh University (3) · Olatec Therapeutics, Inc. (3) · Universidade Federal do Para (3) · University of Colorado, Denver (3) · AbbVie (prior sponsor, Abbott) (2) · Alexandria University (2) · Assiut University (2) · Behar, Caren, M.D. (2)
United States (69) · Egypt (12) · Germany (9) · Brazil (8) · Canada (8) · Italy (7) · India (6) · China (4) · United Kingdom (4) · Czechia (3) · Denmark (3) · Taiwan (3) · Turkey (Türkiye) (3) · Ukraine (3) · Dominican Republic (2)
Michael C Snabes, MD, PhD (4) · Caren Behar, MD (2) · Janet Benesh (2) · Jeremy Paull, PhD. (2) · Stephanie T Page, MD, PhD (2) · A R Pradeep, M.D.S. (1) · Alexa Kimball, MD, MPH (1) · Amira R AL-Agooz (1) · Amy Degnim, M.D. (1) · Andrea Scribante, DDS, PhD (1) · Andrea Z LaCroix, PhD (1) · Andrew Combs, MD (1) · Anna Wald, MD, MPH (1)
PMID 24361112, PMID 25962554, PMID 31779508, PMID 38224135, PMID 15215482, PMID 17453597, PMID 19186342, PMID 20368766, PMID 21177791, PMID 21330907, PMID 21505316, PMID 22172433, PMID 22395584, PMID 22683276, PMID 22760426, PMID 23000649, PMID 23093256, PMID 23165659, PMID 23218853, PMID 23334506, PMID 23494931, PMID 23839181, PMID 23964752, PMID 24012096, PMID 24106072, PMID 24486592, PMID 24898857, PMID 26044291, PMID 26265463, PMID 26950683, PMID 27172434, PMID 27783532, PMID 28404609, PMID 28731373, PMID 28870177, PMID 29554173, PMID 29738424, PMID 29800026, PMID 30297352, PMID 30410934, PMID 30994576, PMID 314790, PMID 32250330, PMID 32542985, PMID 32940653, PMID 32996096, PMID 33251157, PMID 33367735, PMID 33539256, PMID 33675793
2014 (1), 2015 (1), 2016 (1), 2019 (1), 2025 (1), K23AG027238 (1), K23NS070337 (1), N01CN35157 (1), P30CA060553 (1), R01AG027156 (1), R01AG037603 (1), R01AG049762 (1), R01CA237607 (1), R01HD047722 (1), R44HD118927 (1)