2729 completed, 635 unknown, 430 terminated, 278 recruiting. 4451 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 4451 | Completed 2729, Unknown 635, Terminated 430, Recruiting 278, Withdrawn 162, Not yet recruiting 131, Active not recruiting 70, Suspended 9, Enrolling by invitation 7 |
Follow Placebo: new trials by email Literature Review of Placebo trials Research Report on Placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis | Phase 4 | Not yet recruiting | Region Skane | 1000 | 2028-01-01 | 2026-10-19 |
| Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism Levothyroxine Pill, Placebo - Hypothyroidism | Phase 4 | Not yet recruiting | Spyridoula Maraka | 138 | 2027-10-01 | 2026-08-26 |
| Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 246 | 2027-07-01 | 2026-09-29 |
| Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2027-06-01 | 2026-07-01 |
| ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients After Pelvic Pouch Surgery 5-ASA, Placebo - Ulcerative Colitis (UC), Pouchitis | Phase 4 | Not yet recruiting | University Hospital, Linkoeping | 110 | 2027-04-01 | 2026-08-19 |
| Lorazepam for Delirium Prevention in Critically Ill Patients With High Anttila-Index Lorazepam 1 mg, Placebo - Delirium Confusional State | Phase 4 | Not yet recruiting | University Hospital, Basel, Switzerland | 260 | 2027-03-01 | 2026-02-27 |
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| Naoxintong Capsule for Diabetic Nephropathy With Dampness Retention Pattern: A Multicenter, Randomized, Double-Blind, Placebo-Controlled TrialAcronymNXT-DKD Naoxintong Capsule, Placebo - Diabetic Nephropathy | Phase 4 | Not yet recruiting | Chen Xiangmei | 410 | 2027-03-01 | 2026-07-13 |
| Prevent Wheeze Trial Dexamethasone 0.6 mg/kilogram body weight single dose, Placebo - Lower Respiratory Tract Infection (LRTI), Recurrent Wheezing | Phase 4 | Not yet recruiting | Norwegian University of Science and Technology | 486 | 2027-02-01 | 2026-10-05 |
| Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine Atogepant 60 mg, Placebo - Migraine Disorders, Brain, Healthy Adult Participants | Phase 4 | Not yet recruiting | Konrad Peter Weber | 80 | 2027-01-01 | 2026-09-17 |
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder Delayed-release, extended-release methylphenidate, Placebo - ADHD, Cannabis Use Disorder | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 66 | 2026-11-01 | 2026-09-28 |
| These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment. Doxycycline, Placebo - Leptospirosis, Chemoprophylaxis | Phase 4 | Not yet recruiting | Chulalongkorn University | 1000 | 2026-11-01 | 2026-10-08 |
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management Suzetrigine, Placebo - Pelvic Organ Prolapse (POP), Postoperative Pain | Phase 4 | Not yet recruiting | Aditi Talkad | 48 | 2026-11-01 | 2026-10-02 |
| Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children Amoxicillin, Amoxicillin + Clavulanate, Placebo - Acute Otitis Media, AOM - Acute Otitis Media | Phase 4 | Not yet recruiting | Kuopio University Hospital | 219 | 2026-11-01 | 2026-10-16 |
| Intravenous Dexamethasone for ESP Block Analgesia in Children Undergoing Idiopathic Scoliosis Surgery Dexamethasone (0.1 mg/kg), Dexamethasone (0.2 mg/kg), Placebo - Adolescent Idiopathic Scoliosis (AIS) | Phase 4 | Not yet recruiting | Poznan University of Medical Sciences | 90 | 2026-11-01 | 2026-10-22 |
| Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity Placebo, Tirzepatide - Obese Adults | Phase 4 | Not yet recruiting | Mayo Clinic | 30 | 2026-10-26 | 2026-10-26 |
| Study on Changes in Gut Microbiota, Inflammatory Factors, and Bowel Habits Following Oral Administration of Recombinant B-subunit/Whole Cell Cholera Vaccine in a Community Population Receive recombinant B-subunit/whole-cell cholera vaccine, Placebo - Bowel Habits, Gut Microbiomes | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-14 |
| How Well and Safely Does Lemborexant Work for People Who Wake up at Night to Urinate (LENS) Lemborexant tablets, Placebo - Nocturia | Phase 4 | Not yet recruiting | University of Alberta | 35 | 2026-10-15 | 2026-09-25 |
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Diabetes Mellitus, Type 2 (191) · Pain (149) · Pain, Postoperative (133) · Obesity (124) · Depression (107) · Diabetes Mellitus (105) · Pulmonary Disease, Chronic Obstructive (89) · Hypertension (84) · Attention Deficit Disorder with Hyperactivity (80) · Asthma (77) · Heart Failure (74) · Schizophrenia (73) · Depressive Disorder, Major (70) · Inflammation (69) · Sleep Initiation and Maintenance Disorders (68)
Massachusetts General Hospital (52) · University of California, San Francisco (46) · Eli Lilly and Company (44) · Pfizer (39) · Mayo Clinic (38) · Boehringer Ingelheim (37) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (35) · GlaxoSmithKline (34) · Emory University (33) · Ain Shams University (31) · Novartis Pharmaceuticals (29) · Bayer (28) · University of Texas Southwestern Medical Center (28) · AstraZeneca (26) · University of Pennsylvania (26)
United States (1746) · Canada (259) · China (259) · United Kingdom (194) · Germany (187) · Italy (180) · Denmark (162) · Spain (159) · France (152) · South Korea (146) · Netherlands (124) · Brazil (111) · Egypt (111) · Poland (110) · Belgium (101)
Dong-Xin Wang, MD, PhD (17) · Michael Camilleri, MD (8)
PMID 37142273, PMID 25019647, PMID 37160401, PMID 37811711, PMID 39356039, PMID 22594928, PMID 33283264, PMID 34611902, PMID 35141873, PMID 35229613, PMID 38767196, PMID 39963952, PMID 41744113, PMID 11331334, PMID 15364185, PMID 17964349, PMID 19208350, PMID 21060780, PMID 23058854, PMID 23193746, PMID 23972577, PMID 24471459, PMID 24976224, PMID 25173047, PMID 25478944, PMID 25758058, PMID 25858004, PMID 25980552, PMID 26063677, PMID 26066773, PMID 26414968, PMID 26709542, PMID 27207972, PMID 27338778, PMID 28980198, PMID 29531764, PMID 29763572, PMID 30524702, PMID 31081589, PMID 31277720, PMID 31702015, PMID 32803882, PMID 33000470, PMID 33189083, PMID 33210751, PMID 33293204, PMID 34183490, PMID 34433773, PMID 35012490, PMID 35224730
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