9 completed, 8 recruiting, 6 terminated, 6 unknown. 22 Not applicable, 5 Phase 4, 3 Phase 3, 2 Phase 2.
Follow Optimal medical therapy: new trials by email Literature Review of Optimal medical therapy trials Research Report on Optimal medical therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. TricValve System, Optimal medical therapy - Tricuspid Valve Disease, Heart Valve Diseases | Not applicable | Not yet recruiting | P+F Products + Features USA Inc. | 780 | 2026-10-01 | 2026-10-09 |
| Edge-to-edge Mitral Valve Repair in ATTR-CM TEER, Optimal Medical Therapy - Mitral Regurgitation, ATTR-Cardiomyopathy | Not applicable | Recruiting | Medical University of Vienna | 106 | 2024-01-01 | 2026-10-16 |
| Effect of Individualized Exercise in Elderly Patients With Coronary Heart Disease Individual rehabilitation exercise training, optimal medical therapy ：aspirin, clopidogrel, statins. - Coronary Heart Disease | Not applicable | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 200 | 2023-10-17 | 2024-12-31 |
| Effect of PCI on Clinical Prognosis of Chronic Coronary Artery Occlusion PCI, OMT - Coronary Atheroscleroses | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 258 | 2023-09-17 | 2024-12-27 | |
| A Randomized Controlled Trial of InterVapor® in France - The TARGET Trial Treatment plus Optimal Medical Therapy, Optimal Medical Therapy - Emphysema | Not applicable | Terminated | Uptake Medical Technology, Inc. | 3 | 2023-07-21 | 2025-02-27 |
| A Study of Vericiguat in People With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction Vericiguat, Optimal medical therapy - Breast Cancer, Cardiac Dysfunction | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 21 | 2023-07-17 | 2026-08-03 |
| Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation Transcatheter Aortic Valve Implantation, Medical therapy - Aortic Valve Disease | Not applicable | Recruiting | Nanjing First Hospital, Nanjing Medical University | 210 | 2021-05-21 | 2026-04-08 |
| TRISCEND II Pivotal Trial Edwards EVOQUE System, Optimal Medical Therapy - Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency | Not applicable | Active not recruiting | Edwards Lifesciences | 864 | 2021-04-09 | 2026-02-27 |
| COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina Coronary sinus reducer, Optimal medical therapy - Coronary Microvascular Disease, Refractory Angina | Not applicable | Recruiting | Johannes Gutenberg University Mainz | 144 | 2021-04-01 | 2023-09-28 |
| EndovaScular Versus mediCaL mAnagement of Uncomplicated Type B Intramural heMatoma Trial (ESCLAIM) Thoracic endovascular aortic repair plus optimal medical therapy, Optimal medical therapy - Intramural Hematoma | Not applicable | Unknown | Guangdong Provincial People's Hospital | 154 | 2021-03-01 | 2021-06-03 |
| Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. or coronary balloons, drug-coated balloon - Coronary Artery Disease, Coronary Occlusion | Not applicable | Unknown | Beijing Anzhen Hospital | 200 | 2021-02-01 | 2021-02-09 |
| Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial Edwards PASCAL System, Optimal Medical Therapy - Tricuspid Regurgitation, Tricuspid Valve Insufficiency | Not applicable | Recruiting | Edwards Lifesciences | 1270 | 2019-12-11 | 2026-09-14 |
| ISCHEMIA-CTO Trial - Revascularisation or Optimal Medical Therapy of CTO Percuteneous Coronary Intervention, Optimal Medical Therapy - Ischemic Heart Disease, Chronic Total Occlusion of Coronary Artery | Not applicable | Recruiting | Aarhus University Hospital Skejby | 1560 | 2018-11-06 | 2026-01-02 |
| The Role of Willingness of Participation in Cardiology Trials on the Survival of Patients Optimal medical therapy - Myocardial Infarction, Chronic Heart Failure | Unknown | Semmelweis University Heart and Vascular Center | 400 | 2018-10-01 | 2019-02-15 | |
| The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. stents or coronary balloons - Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention | Unknown | Beijing Anzhen Hospital | 240 | 2018-04-10 | 2020-09-01 | |
| Allopurinol and Endothelial Function in Diabetic CAD Patients Allopurinol - Diabetes Mellitus, Coronary Artery Disease | Not applicable | Unknown | University Tunis El Manar | 58 | 2017-12-01 | 2017-12-28 |
| Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF MitraClip, Optimal Medical Therapy, CRT-D - Functional Mitral Regurgitation, Heart Failure | Not applicable | Withdrawn | Montreal Heart Institute | 2016-12-01 | 2020-02-27 | |
| Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death Implantable Cardioverter Defibrillator, Optimal Medical Therapy - Angina Pectoris, Variant, Sudden Cardiac Death | Phase 4 | Recruiting | Kee-joon Choi | 140 | 2016-11-29 | 2026-06-25 |
| Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study Left Cardiac Sympathetic Denervation (LCSD), Optimal Medical Therapy - Dilated Cardiomyopathy, Ischemic Cardiomyopathy | Phase 2 | Suspended | University of Cape Town | 30 | 2016-11-24 | 2021-05-06 |
| The British Heart Foundation SENIOR-RITA Trial Coronary Angiography, Coronary revascularisation, Optimal Medical Therapy - NSTEMI - Non-ST Segment Elevation MI | Not applicable | Active not recruiting | Newcastle-upon-Tyne Hospitals NHS Trust | 1518 | 2016-11-01 | 2024-07-19 |
Showing 20 of 35. Sign in to see all of them.
Coronary Artery Disease (8) · Heart Failure (8) · Cardiovascular Diseases (6) · Coronary Disease (4) · Heart Diseases (4) · Myocardial Infarction (4) · Emphysema (3) · Tricuspid Valve Insufficiency (3) · Cardiomyopathies (2) · Heart Valve Diseases (2) · Mitral Valve Insufficiency (2) · Acute Coronary Syndrome (1) · Angina Pectoris (1) · Angina Pectoris, Variant (1) · Angina, Stable (1)
Beijing Anzhen Hospital (2) · Edwards Lifesciences (2) · The First Affiliated Hospital with Nanjing Medical University (2) · Aarhus University Hospital Skejby (1) · Aeris Therapeutics (1) · Assistance Publique - Hôpitaux de Paris (1) · Clinical Centre of Serbia (1) · Columbia University (1) · Golden Jubilee National Hospital (1) · Guangdong Provincial People's Hospital (1) · Impulse Dynamics (1) · Johannes Gutenberg University Mainz (1) · Kee-joon Choi (1) · Kerckhoff Klinik (1) · Medical University of Vienna (1)
United States (9) · Germany (7) · China (6) · France (4) · United Kingdom (4) · Austria (3) · Italy (3) · Canada (2) · Poland (2) · South Korea (2) · Spain (2) · Sweden (2) · Australia (1) · Denmark (1) · Estonia (1)
Leilei Chen (2) · Allen Anderson, MD (1) · Anita Asgar, MD (1) · Anthony Yu, MD, MS (1) · Charles Davidson, MD (1) · Christian Nitsche, MD, PhD (1) · Claudia Walther, MD (1) · Dr Vijay Kunadian, MBBS MD FRCP (1) · Eric J. Rashba, MD (1) · Eric Rose, MD (1) · Evald Christiansen, MD PhD (1) · Felix JF Herth, MD (1) · Gerhard Hindricks, Prof. (1) · Gian Paolo Rossi, MD, FACC (1)
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R01HL067683 (1), R01HL070011 (1), R01HL072906 (1), U01HL053986 (1)