25 completed, 3 recruiting, 3 terminated, 1 active not recruiting. 15 Not applicable, 8 Phase 4, 6 Phase 3, 3 Early Phase 1, 3 Phase 2.
Follow Nicotine Gum: new trials by email Literature Review of Nicotine Gum trials Research Report on Nicotine Gum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| iCanQuit Smoking Cessation Among Hispanic Adults iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch - Cigarette Smoking-Related Carcinoma | Phase 3 | Not yet recruiting | Fred Hutchinson Cancer Center | 854 | 2026-10-15 | 2026-09-21 |
| Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product - Smoking Cessation, Harm Reduction | Phase 3 | Completed | Rose Research Center, LLC | 150 | 2024-08-29 | 2026-02-06 |
| Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product - Smoking Cessation, Harm Reduction | Phase 3 | Terminated | Rose Research Center, LLC | 4 | 2023-12-27 | 2025-03-30 |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Smoking Cessation and Menstrual Cycle Phase Timing of nicotine replacement therapy start date, Nicotine Replacement Therapy Agent - Nicotine Dependence, Tobacco Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 1200 | 2022-11-30 | 2026-03-19 |
| Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex Nicotine gum, Placebo gum - Aging | Early Phase 1 | Completed | University of California, Berkeley | 44 | 2022-06-06 | 2026-07-24 |
| Easy Access to Smoking Cessation for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco Nicotine patch, Nicotine gum, Nicotine lozenge - Smoking Cessation, Substance-Related Disorders | Not applicable | Active not recruiting | Haukeland University Hospital | 266 | 2022-04-07 | 2024-06-28 |
| Using Nicotine to Reverse Age-related Auditory Processing Deficits Nicotine gum, Placebo gum - Auditory Perceptual Impairment, Aging | Not applicable | Recruiting | University of California, Irvine | 48 | 2022-02-01 | 2026-10-19 |
| Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch - Tobacco Use Disorder, Mental Illness | Not applicable | Completed | Wake Forest University Health Sciences | 343 | 2021-09-21 | 2026-10-21 |
| QuitAid Pilot Feasibility Trial Nicotine patch, Nicotine gum, Medication Therapy Management - Smoking Cessation | Not applicable | Completed | University of Virginia | 24 | 2021-08-31 | 2022-12-14 |
| Research and Innovation to Stop E-cigarette/Vaping in Young Adults Nicotine patch, Phone Counseling, Digital Coaching - Nicotine Dependence, E-Cig Use | Phase 4 | Completed | Ohio State University | 508 | 2021-07-28 | 2024-07-29 |
| Studying the Role of Brain Molecules for Decision Making Methylphenidate, Reboxetine, Nicotine gum - Decision Making, Healthy | Not applicable | Completed | University of Zurich | 160 | 2020-12-17 | 2024-05-08 |
| Inpatient Smoking Cessation Pilot Program Nicotine lozenge, Nicotine gum, Nicotine patch - Tobacco Use Cessation | Early Phase 1 | Withdrawn | Johns Hopkins University | 2019-10-01 | 2023-08-15 | |
| United States Pre-Market Tobacco Application Pharmacokinetics Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS - Nicotine Dependence, Nicotine Dependence, Cigarettes | Not applicable | Completed | Juul Labs, Inc. | 67 | 2018-10-19 | 2021-06-14 |
| End Nicotine Dependence Clinic Group Counseling, Individual Counseling, Phone Counseling - Smoking Cessation | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 56 | 2018-01-09 | 2020-04-14 |
| A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers Oromucosal Nicotine Spray (ONS), Nicotine Gum, Cigarette - Healthy | Phase 1 | Completed | Janssen Pharmaceutical K.K. | 24 | 2017-12-22 | 2025-02-03 |
| Treating Smokeless Tobacco Use in Rural Veterans Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management - Smokeless Tobacco, Nicotine Dependence | Not applicable | Unknown | Mark Vander Weg | 123 | 2016-12-01 | 2019-07-24 |
| Changing the Default for Tobacco Treatment Opt Out Treatment Program, Nicotine Replacement Therapy, Opt In Treatment Program - Tobacco Use Cessation | Phase 4 | Completed | University of Kansas Medical Center | 1000 | 2016-09-01 | 2022-12-01 |
| The Effects of Nicotine Chewing Gum in Parkinson's Disease Nicotine gum - Low Blood Pressure, Parkinsons Disease | Not applicable | Completed | New York Institute of Technology | 10 | 2015-05-01 | 2017-07-28 |
| Mobile Contingency Management for Smoking Cessation in Returning US Veterans Nicotine gum, mobile contingency management, Telephone counseling - Smoking, Veterans | Not applicable | Completed | Duke University | 291 | 2015-01-01 | 2020-02-21 |
Showing 20 of 35. Sign in to see all of them.
Smoking Cessation (19) · Tobacco Use Disorder (14) · Harm Reduction (4) · Smoking (4) · Tobacco Use Cessation (3) · Vaping (3) · Substance-Related Disorders (2) · Tobacco Smoking (2) · Tobacco Use (2) · Auditory perceptual impairment (1) · Bipolar Disorder (1) · Hypotension (1) · Ileus (1) · Medication Adherence (1) · Mental Disorders (1)
McNeil AB (4) · Centre for Addiction and Mental Health (2) · Johns Hopkins University (2) · Rose Research Center, LLC (2) · University of Wisconsin, Madison (2) · Case Comprehensive Cancer Center (1) · Creighton University (1) · Duke University (1) · Fertin Pharma A/S (1) · Fred Hutchinson Cancer Center (1) · Haukeland University Hospital (1) · Hospital Authority, Hong Kong (1) · Janssen Pharmaceutical K.K. (1) · Johnson & Johnson Consumer and Personal Products Worldwide (1) · Juul Labs, Inc. (1)
United States (22) · Sweden (3) · Canada (2) · China (1) · Czechia (1) · Japan (1) · Norway (1) · South Africa (1) · Switzerland (1)
Elisabeth Kruse, PhD (4) · Amy J Arouni, MD (1) · David Chao, FHKAM (1) · Dorothy Hatsukami, Ph.D. (1) · Elizabeth G Klein, PhD (1) · Eric T. Moolchan, M.D. (1) · Fan-Gang Zeng, PhD (1) · Jackie Mao (1) · Jessica Cook, PhD (1) · Joanne Donoghue, PhD (1) · Jonathan Bricker, PhD (1) · Jonathan E Golub, PhD MPH (1) · Kimber Richter, PhD (1)
PMID 37335995, PMID 22992296, PMID 28806908, PMID 31619205, PMID 31832719, PMID 35435813, PMID 35978355, PMID 36848129, PMID 37005655, PMID 37639601, PMID 38184633, PMID 38409089, PMID 39665734, PMID 39937506, PMID 40543725
R01AG067073 (2), 1RC1CA144382-01 (1), 2008 (1), 2009 (1), P50CA143188 (1), R01CA135884 (1), R01CA298383 (1), R01DA047301 (1), R01HL131512 (1), U01CA261626 (1)