12 completed, 3 not yet recruiting, 1 active not recruiting, 1 recruiting. 6 Phase 2, 5 Not applicable, 5 Phase 4, 2 Phase 1, 2 Phase 3.
Follow Nicorette: new trials by email Literature Review of Nicorette trials Research Report on Nicorette
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| iCanQuit Smoking Cessation Among Hispanic Adults iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch - Cigarette Smoking-Related Carcinoma | Phase 3 | Not yet recruiting | Fred Hutchinson Cancer Center | 854 | 2026-12-01 | 2026-10-29 |
| Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Not yet recruiting | Xianhui Wang | 20 | 2026-11-01 | 2026-10-21 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Completed | San Diego State University | 29 | 2026-03-25 | 2026-10-16 |
| Smoking Cessation Program in the Construction Sector Nicorette, Tobacco Quit-line, Brief Behavioral Counseling - Smoking Cessation, Tobacco Use Cessation | Phase 4 | Active not recruiting | University of Miami | 608 | 2024-04-10 | 2026-08-21 |
| WeChat Quit Coach Pilot Study WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges - Smoking Cessation | Not applicable | Completed | NYU Langone Health | 150 | 2022-02-10 | 2026-07-31 |
| Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon Cinnamon (2 g), Nicotine gum (2.5 mg), Letrozole (2.5 mg) - Interaction Drug Food | Early Phase 1 | Completed | Washington State University | 16 | 2021-12-14 | 2026-08-24 |
| QuitAid Pilot Feasibility Trial Nicotine patch, Nicotine gum, Medication Therapy Management - Smoking Cessation | Not applicable | Completed | University of Virginia | 24 | 2021-08-31 | 2022-12-14 |
| Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling - Tobacco Use Disorder, Homelessness | Phase 4 | Completed | VA Office of Research and Development | 133 | 2014-10-01 | 2022-01-04 |
| A Smoking Cessation Trial in HIV-infected Patients in South Africa Nicotine, Intensive Counseling - Smoking Cessation, HIV | Not applicable | Completed | Johns Hopkins University | 560 | 2014-03-28 | 2019-10-04 |
| Smoking Habits and Smoking Cessation in Young Adults varenicline, Nicotine cutaneous patch 15mg/16h, Nicotine cutaneous patch 10mg/16h - Smoking Cessation, Smoking | Phase 2 / Phase 3 | Completed | Tuula Toljamo | 300 | 2012-05-01 | 2017-06-05 |
| Preliminary Investigation of Novel Methods to Reduce Children's Secondhand Smoke Exposure Nicotine polacrilex, Electronic Cigarette, Dissolvable Tobacco Lozenge - Secondhand Smoke | Not applicable | Completed | University of Oklahoma | 89 | 2012-04-01 | 2026-04-06 |
| Varenicline in Combination With Nicotine Replacement Therapy for Smoking Cessation Varenicline, Nicotine Patch, Varenicline and Placebo Patch - Tobacco Dependence | Phase 2 | Completed | University of Stellenbosch | 446 | 2011-04-01 | 2014-03-26 |
| Effect of Smoking Cessation on Clinical and Microbiological Outcomes of the Non-surgical Periodontal Therapy Smoking cessation counseling, Non-surgical periodontal therapy, Nicotine replacement therapy - Periodontitis | Not applicable | Completed | Claudio Mendes Pannuti | 63 | 2010-08-01 | 2018-11-06 |
| Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine Oral tobacco, Nicotine Gum - Tobacco Use Disorder | Phase 2 | Completed | University of Minnesota | 391 | 2010-04-01 | 2017-12-06 |
| Effect of Daily Nicotine Patch Application on Mechanical Ventilation Weaning in Smoking Patients Nicotine patch, Placebo - Smoking, Mechanical Ventilation | Phase 4 | Unknown | University of Paris 5 - Rene Descartes | 600 | 2010-01-01 | 2010-04-16 |
| Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1 Nicotine Replacement Therapies, Nicotine patch, Folic Acid - Smoking Cessation, Tobacco Use Disorder | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 128 | 2002-04-01 | 2017-01-10 |
Smoking Cessation (8) · Tobacco Use Disorder (5) · Smoking (4) · Cigarette Smoking (2) · Tinnitus (2) · Tobacco Use Cessation (2) · Habits (1) · Harm Reduction (1) · Periodontitis (1) · Smoking Reduction (1) · Substance-Related Disorders (1) · Tobacco Smoking (1)
VA Office of Research and Development (3) · Claudio Mendes Pannuti (1) · Fred Hutchinson Cancer Center (1) · Johns Hopkins University (1) · NYU Langone Health (1) · National Institute on Drug Abuse (NIDA) (1) · San Diego State University (1) · Tuula Toljamo (1) · University of Miami (1) · University of Minnesota (1) · University of Oklahoma (1) · University of Paris 5 - Rene Descartes (1) · University of Stellenbosch (1) · University of Virginia (1) · Washington State University (1)
United States (13) · South Africa (2) · Finland (1) · France (1)
Dorothy Hatsukami, Ph.D. (2) · Xianhui Wang (2) · Claudio M Pannuti, PhD (1) · Didier Journois, M.D. Ph.D. (1) · Elvis M Irusen, MBChB, FCP, PhD (1) · Jean C Beckham, PhD (1) · Jennifer M. Betts, PhD (1) · Jessica Megan Cook, PhD (1) · Jonathan Bricker, PhD (1) · Jonathan Golub, PhD (1) · Melissa Little, PhD (1) · Nan Jiang, PhD (1) · Neal M Doran, PhD (1) · Pentti Nieminen, PhD (1) · Taghrid Asfar, MD (1)
PMID 24794687, PMID 25005652, PMID 37142273, PMID 38409089, PMID 39037756, PMID 40489501
K01MD014165 (1), R01CA135884 (1), R01CA298383 (1), R01DA030276 (1), U54AT008909 (1)