8 completed, 1 not yet recruiting, 1 unknown. 10 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 8, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 3 |
Follow Nefopam: new trials by email Literature Review of Nefopam trials Research Report on Nefopam
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO) Nefopam, NaCl 0.9% - Total Hip Arthroplasty | Phase 3 | Not yet recruiting | University Hospital, Tours | 546 | 2024-04-01 | 2024-04-05 |
| Role of Nefopam in Rituximab Transfusion Reaction Nefopam ampule, diphenhydramine ampule - Nefopam | Phase 3 | Unknown | Ministry Of Health / Nineveh Health Directorate | 100 | 2022-12-20 | 2022-12-15 |
| Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium. - Analgesia, Critical Illness | Phase 3 | Completed | Cairo University | 60 | 2021-10-01 | 2025-12-19 |
| Nonopioid Analgesics and Cholecystectomy nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol - Cholecystectomy, Pain, Postoperative | Phase 3 | Completed | American University of Beirut Medical Center | 90 | 2021-04-08 | 2023-05-06 |
| Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction nefopam hydrochloride 30mg / paracetamol 500mg X2, Paracetamol 500 Mg Oral Tablet X2, Nefopam HCl 30 MG Oral Tablet X2 - Acute Pain | Phase 3 | Completed | Unither Pharmaceuticals, France | 321 | 2020-02-22 | 2024-11-27 |
| Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section Nefopam 20 MG/ML, "Nefopam (Acupan)" 20 MG/ML Injectable Solution, "Acetaminophen, (paracetamol)" 500Mg Tab - Cesarean Section; Complications, Wound, Infection (Following Delivery), Postoperative Pain | Phase 2 / Phase 3 | Completed | Centre de Maternité de Monastir | 200 | 2015-01-01 | 2018-08-15 |
| Epidural Analgesia for Pancreatitis (Epipan Study) ropivacaine and sufentanil, acetaminophen, nefopam, tramadol, opidoids - Severe Acute Pancreatitis | Phase 3 | Completed | University Hospital, Clermont-Ferrand | 148 | 2014-06-06 | 2026-08-03 |
| Nefopam/Fentanyl Postoperative Intravenous Patient-Controlled-Analgesia Nefopam, Saline - Laparotomy | Phase 2 / Phase 3 | Completed | Seoul National University Hospital | 73 | 2012-10-01 | 2015-11-05 |
| Non Opioid Treatment for Experimental Dyspnea Nefopam - Dyspnea, Pain | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 15 | 2011-09-01 | 2012-12-11 |
| Effects of Nefopam on Hyperalgesia After Cardiac Surgery Nefopam, néfopam, Placebo comparator - Hyperalgesia, Pain, Postoperative | Phase 2 / Phase 3 | Completed | University Hospital, Bordeaux | 90 | 2006-12-01 | 2010-05-28 |
Pain, Postoperative (4) · Pain (3) · Agnosia (2) · Acute Pain (1) · Chronic Disease (1) · Critical Illness (1) · Delirium (1) · Dyspnea (1) · Hyperalgesia (1) · Infections (1) · Pancreatitis (1) · Wounds and Injuries (1)
American University of Beirut Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Cairo University (1) · Centre de Maternité de Monastir (1) · Ministry Of Health / Nineveh Health Directorate (1) · Seoul National University Hospital (1) · Unither Pharmaceuticals, France (1) · University Hospital, Bordeaux (1) · University Hospital, Clermont-Ferrand (1) · University Hospital, Tours (1)
France (5) · Belgium (1) · Egypt (1) · Hungary (1) · Lebanon (1) · Russia (1) · Tunisia (1) · United Kingdom (1)
Capucine Morelot, MD, PhD (1) · Mohammed Gamal Abdelraouf Amer, Pharm D (1) · Sahar Sayyid, MD (1) · Yong Chul Kim, MD., PhD. (1)
PMID 23063945, PMID 27358262, PMID 28554928, PMID 37259157, PMID 40250620