23 completed, 5 terminated, 2 recruiting, 1 unknown. 31 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 31 | Completed 23, Terminated 5, Recruiting 2, Unknown 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel Modafinil (M), 200 mg Microcrystalline Cellulose - Sleep Deprivation, Cold Exposure | Phase 4 | Recruiting | United States Army Research Institute of Environmental Medicine | 33 | 2025-02-18 | 2026-09-21 |
| Investigation of Locus Coeruleus Function in Sustained Attention Modafinil - Attention - no Condition is Being Assessed - Healthy Adults | Phase 4 | Recruiting | University of California, Davis | 40 | 2023-10-01 | 2026-06-18 |
| Cognitive Behavioral Therapy, Modafinil, or Both for Multiple Sclerosis Fatigue Telephone-based Cognitive Behavioral Therapy, Modafinil - Multiple Sclerosis | Phase 4 | Completed | University of Michigan | 343 | 2018-11-15 | 2022-12-27 |
| Modafinil Effects on EEG Biomarkers of Reward and Motivation Modafinil, placebo - Healthy Adults | Phase 4 | Completed | University of California, San Diego | 23 | 2018-10-16 | 2022-04-06 |
| Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea Modafinil, Placebo - Obstructive Sleep Apnea, Delayed Emergence From Anesthesia | Phase 4 | Terminated | Milton S. Hershey Medical Center | 105 | 2016-02-01 | 2019-06-20 |
| Pain Expectations in Subjects With Osteoarthritis Modafinil, Gabapentin, Placebo - Osteoarthritis | Phase 4 | Completed | Wake Forest University Health Sciences | 30 | 2014-07-01 | 2019-03-07 |
| Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil Modafinil, Placebo - Bipolar Disorder | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 18 | 2014-01-01 | 2018-03-21 |
| Antipsychotic Effects on Brain Function in Schizophrenia Aripiprazole, Risperidone, Modafinil - Schizophrenia, Schizoaffective Disorder | Phase 4 | Terminated | University of California, San Francisco | 4 | 2013-04-01 | 2020-04-20 |
| The Efficacy and Tolerability of Modafinil for Fatigue and Daytime Sleepiness in Cancer Patients: Preliminary Study Modafinil - Fatigue | Phase 4 | Unknown | Seoul National University Bundang Hospital | 20 | 2013-03-01 | 2015-03-11 |
| Effect of Nuvigil on Fatigue Armodafinil - Menopause | Phase 4 | Completed | Massachusetts General Hospital | 25 | 2011-10-01 | 2017-03-15 |
| Armodafinil for Patients Starting Hepatitis C Virus Treatment Armodafinil, Sugar Pill - Hepatitis C | Phase 4 | Terminated | Research Foundation for Mental Hygiene, Inc. | 26 | 2011-10-01 | 2017-02-10 |
| Effectiveness of Modafinil in Improving Cognitive Performance of University Students Modafinil - Attention, Memory, Short-Term | Phase 4 | Completed | Universidad de Valparaiso | 128 | 2010-09-01 | 2011-06-03 |
| Efficacy and Tolerability of Armodafinil in Adults With Excessive Sleepiness Associated With Shift Work Disorder Armodafinil, Matching Placebo - Excessive Sleepiness | Phase 4 | Completed | Cephalon | 385 | 2010-03-01 | 2012-06-20 |
| "Pilot Study of Armodafinil in Patients With Dementia With Lewy Bodies" Armodafinil - Dementia With Lewy Bodies | Phase 4 | Completed | Mayo Clinic | 20 | 2009-11-01 | 2013-09-05 |
| Modafinil for the Treatment of Fatigue in Lung Cancer V9.0 Modafinil, Placebo - Carcinoma, Non-Small-Cell Lung | Phase 4 | Completed | University of Oxford | 208 | 2009-02-01 | 2013-08-19 |
| Effects of Modafinil in Methamphetamine Dependence Modafinil, Placebo - Methamphetamine Dependence | Phase 4 | Completed | Medical University of South Carolina | 40 | 2009-02-01 | 2019-06-13 |
| Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance Armodafinil, Placebo - Excessive Sleepiness | Phase 4 | Completed | Cephalon | 40 | 2008-09-01 | 2013-07-19 |
| Effectiveness of Armodafinil for Treating Fatigue in Adults With HIV/AIDS Armodafinil, Placebo - HIV Infections, Fatigue | Phase 4 | Completed | New York State Psychiatric Institute | 70 | 2008-06-01 | 2014-06-12 |
| Modafinil Effects on Cognition in Schizophrenia Patients modafinil (M1, M2, M4) - Schizophrenia | Phase 4 | Completed | University of California, Los Angeles | 29 | 2008-05-01 | 2017-09-29 |
| Modafinil Treatment for Sleep/Wake Disturbances in Older Adults modafinil - Insomnia, Sleep Initiation and Maintenance Disorders | Phase 4 | Terminated | VA Palo Alto Health Care System | 2 | 2008-02-01 | 2019-10-28 |
Showing 20 of 31. Sign in to see all of them.
Fatigue (10) · Schizophrenia (5) · Disorders of Excessive Somnolence (4) · Depression (3) · Psychotic Disorders (3) · Sleep Apnea, Obstructive (3) · Acquired Immunodeficiency Syndrome (2) · Depressive Disorder, Major (2) · HIV Infections (2) · Sleep Initiation and Maintenance Disorders (2) · Alzheimer Disease (1) · Behavior, Addictive (1) · Bipolar Disorder (1) · Carcinoma, Non-Small-Cell Lung (1) · Cognitive Dysfunction (1)
Cephalon (3) · New York State Psychiatric Institute (3) · University of California, Los Angeles (2) · Emory University (1) · Icahn School of Medicine at Mount Sinai (1) · Jazz Pharmaceuticals (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Medical University of South Carolina (1) · Milton S. Hershey Medical Center (1) · North Suffolk Mental Health Association (1) · Northwestern University (1) · Research Foundation for Mental Hygiene, Inc. (1) · Seoul National University Bundang Hospital (1) · State University of New York - Upstate Medical University (1)
United States (27) · Canada (1) · Chile (1) · Germany (1) · South Korea (1) · United Kingdom (1)
Bee Wee, PhD (1) · Bradley F Boeve, MD (1) · Bryan K Tolliver, MD, PhD (1) · Cameron S Carter, MD (1) · Caterina Breitenstein, PhD (1) · Donald Goff, MD (1) · Eva Madrid, PhD (1) · Franco Mascayano, Psychologist (1) · Hadine Joffe, MD, MSc (1) · Inyoung Yoon, M.D., Ph.D. (1) · James C Eisenach, M.D. (1) · Jamie M Zeitzer, PhD (1)
PMID 16880771, PMID 19689921, PMID 20051221, PMID 20492840, PMID 21641776, PMID 21777715, PMID 22104981, PMID 23251870, PMID 24532997, PMID 24778393, PMID 33189083, PMID 37732080, PMID 39424559
R01MH072383 (2), P50AG016574 (1), R01AG015866 (1), R34MH101267 (1)