9 completed, 2 recruiting, 2 unknown, 1 terminated. 8 Phase 4, 4 Phase 2, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 8 | Completed 5, Unknown 2, Recruiting 1 |
| Phase 2 | 4 | Completed 3, Recruiting 1 |
| Phase 3 | 4 | Completed 2, Recruiting 1, Terminated 1 |
Follow Midodrine Hydrochloride: new trials by email Literature Review of Midodrine Hydrochloride trials Research Report on Midodrine Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension Midodrine Oral Tablet - Heart Failure With Reduced Ejection Fraction, Hypotension | Phase 2 / Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 56 | 2026-08-07 | 2026-09-08 |
| Treatment of Orthostatic Hypotension in SCI Midodrine Hydrochloride - Hypotension | Phase 4 | Recruiting | James J. Peters Veterans Affairs Medical Center | 25 | 2023-07-01 | 2026-08-10 |
| Midodrine for the Early Liberation of Vasopressor Support in the ICU Midodrine, Placebo - Critical Illness, Shock | Phase 4 | Completed | University of Alberta | 20 | 2021-03-22 | 2023-10-06 |
| Midodrine Versus Albumin for Prevention of Paracentesis Induced Circulatory Disturbance Midodrine Hydrochloride, Human Albumin 20% - Paracentesis-Induced Circulatory Dysfunction | Phase 3 | Completed | Asian Institute of Gastroenterology, India | 50 | 2021-02-20 | 2022-05-10 |
| RaGuS Trial by Postoperative Patients Midodrine Hydrochloride, Placebo - Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction | Phase 4 | Unknown | Bürgerspital Solothurn | 50 | 2020-09-14 | 2020-06-19 |
| Midodrine Use in Septic Shock Midodrine Hydrochloride, placebo - Septic Shock | Phase 3 | Terminated | University of Virginia | 10 | 2018-11-05 | 2025-09-24 |
| Treatment of Post-SCI Hypotension Midodrine Hydrochloride - Spinal Cord Injury, Autonomic Dysreflexia | Phase 2 / Phase 3 | Completed | James J. Peters Veterans Affairs Medical Center | 66 | 2017-06-01 | 2025-02-21 |
| The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury Midodrine Hydrochloride, Pyridostigmine Bromide, Mirabegron - Spinal Cord Injury, Autonomic Dysreflexia | Phase 2 | Completed | James J. Peters Veterans Affairs Medical Center | 21 | 2016-12-01 | 2024-10-01 |
| Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Midodrine Hydrochloride, Cool Temperature - Tetraplegia, Hypothermia | Phase 4 | Completed | James J. Peters Veterans Affairs Medical Center | 30 | 2015-04-01 | 2025-03-21 |
| Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV midodrine hydrochloride, matching placebo - Vasovagal Syncope | Phase 4 | Unknown | Dr. Bob Sheldon | 134 | 2011-11-01 | 2024-05-09 |
| Body Temperature in Persons With Tetraplegia When Exposed to Cold Midodrine hydrochloride - Tetraplegia, Hypothermia | Phase 4 | Completed | James J. Peters Veterans Affairs Medical Center | 30 | 2011-07-01 | 2016-03-04 |
| A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride Midodrine Hydrochloride - Orthostatic Hypotension, Spinal Cord Injury | Phase 2 | Completed | James J. Peters Veterans Affairs Medical Center | 11 | 2007-01-01 | 2016-10-10 |
| Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Midodrine hydrochloride, Placebo - Hypotension, Orthostatic | Phase 4 | Completed | Shire | 24 | 2004-09-08 | 2021-06-14 |
| A Study for Patients With Neurogenic Orthostatic Hypotension Midodrine Hydrochloride - Hypotension, Orthostatic | Phase 4 | Completed | Shire | 140 | 1997-12-01 | 2021-06-11 |
Hypotension, Orthostatic (5) · Spinal Cord Injuries (5) · Hypotension (3) · Autonomic Dysreflexia (2) · Cognitive Dysfunction (2) · Hypothermia (2) · Quadriplegia (2) · Ascites (1) · Critical Illness (1) · Heart Failure (1) · Shock (1) · Shock, Septic (1) · Syncope, Vasovagal (1) · Vasoplegia (1) · Ventricular Dysfunction, Left (1)
James J. Peters Veterans Affairs Medical Center (6) · Shire (2) · Asian Institute of Gastroenterology, India (1) · Bürgerspital Solothurn (1) · Dr. Bob Sheldon (1) · Ottawa Heart Institute Research Corporation (1) · University of Alberta (1) · University of Virginia (1)
United States (10) · Canada (3) · India (1) · Poland (1)
John P Handrakis, PT, DPT, EdD (2) · Alexandra Kadl, MD (1) · Ian Paterson, MD (1) · Jill M Wecht, Ed.D (1) · Jill M Wecht, Ed.D. (1) · Jill Wecht, EdD (1) · Marcos Delgado, MD (1) · Oleksa G Rewa, MD MSc (1) · William Bauman, MD (1)
PMID 20801263, PMID 21762873, PMID 22610268, PMID 23845791, PMID 24100756, PMID 25531297, PMID 26492477, PMID 26953217, PMID 28327122, PMID 29223724, PMID 31107279, PMID 31334462, PMID 32145658, PMID 32274344, PMID 34339231, PMID 34626828, PMID 35366432, PMID 38712567, PMID 39633467