25 completed, 13 recruiting, 4 unknown, 3 active not recruiting. 28 Not applicable, 7 Phase 2, 4 Phase 3, 4 Phase 4.
Follow Medical management: new trials by email Literature Review of Medical management trials Research Report on Medical management
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| REVIVE-FR Registry TAVI-in-SAVR (Valve-in-Valve), THV-in-THV (Redo-TAVI), Surgical Explantation of a Failed Transcatheter Heart Valve - Bioprosthetic Valve Failure, Prosthetic Heart Valve Dysfunction | Not yet recruiting | Institut für Pharmakologie und Präventive Medizin | 200 | 2027-03-15 | 2026-10-21 | |
| FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions Endovascular Thrombectomy, Medical Management - Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion | Recruiting | Penumbra Inc. | 250 | 2026-06-26 | 2026-10-15 | |
| Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well Endovascular Thrombectomy, Medical Management - Acute Ischemic Stroke | Not applicable | Recruiting | Amrou Sarraj | 408 | 2026-04-13 | 2026-07-06 |
| Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis Remote Ischemic Conditioning (RIC) treatment, Medical Management - Acute Ischemic Stroke | Not applicable | Recruiting | First Affiliated Hospital Xi'an Jiaotong University | 1150 | 2025-08-10 | 2025-08-14 |
| Pioneering Advancements in Cardiocerebrovascular Interactions in the Asia pacFIC - Patent Foramen Ovale Study PFO closure using approved PFO closure devices, Surgical PFO closure, Medical management - Ischemic Stroke, Patent Foramen Ovale | Not yet recruiting | National University Hospital, Singapore | 1000 | 2025-07-01 | 2025-05-21 | |
| Rapid Evacuation and Access of Cerebral Hemorrhage Trial Surgical management, Medical Management - Stroke Hemorrhagic | Not applicable | Recruiting | Emory University | 600 | 2025-05-27 | 2026-08-14 |
| StrokeNet Thrombectomy Endovascular Platform Endovascular thrombectomy with any FDA-approved category POL or NRY device, Medical Management - Ischemic Stroke | Not applicable | Recruiting | Medical University of South Carolina | 1600 | 2025-01-31 | 2025-12-04 |
| Endovascular Treatment for eXtra-Large Ischemic Stroke Medical management, Endovascular thrombectomy - Stroke, Acute Ischemic | Not applicable | Recruiting | Zhongming Qiu | 286 | 2024-06-16 | 2025-12-26 |
| The Treatment of Painful Diabetic Neuropathy With Diet Diet, Medical management - Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes | Not applicable | Recruiting | AdventHealth | 40 | 2024-04-23 | 2026-04-30 |
| Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke medical management, endovascular thrombectomy - Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion | Recruiting | Zhongming Qiu | 1000 | 2024-01-20 | 2025-12-31 | |
| Evaluation of Advanced Practice Nurse's Management of Patients With Chronic Myeloid Leukemia APN and medical management, Medical management, Quality of life assessment - Chronic Myelogenous Leukemia - Chronic Phase | Not applicable | Recruiting | Centre Hospitalier Henri Duffaut - Avignon | 60 | 2023-11-29 | 2026-03-04 |
| Treatment With Endovascular Intervention for STroke Patients With Existing Disability Endovascular Stroke Treatment, Medical Management - Stroke, Stroke, Acute | Recruiting | University of Cincinnati | 1060 | 2023-11-16 | 2026-09-02 | |
| Enhanced Clinical Decisions for Management of Benign Prostatic Hyperplasia Using Patient-Reported Outcomes Medical Management, Surgical Management - Benign Prostatic Hyperplasia | Recruiting | Northwestern University | 300 | 2023-06-01 | 2026-08-24 | |
| Ibudilast for Treating Alcohol Use Disorder Ibudilast, Medical management, Placebo - Alcohol Use Disorder (AUD), Alcoholism | Phase 2 | Active not recruiting | University of Pennsylvania | 50 | 2023-01-14 | 2026-06-03 |
| Integrated Digital Intervention for Alcohol Use Disorder Mobile health application, Medical Management - Alcohol Use Disorder | Phase 2 / Phase 3 | Completed | Quit Genius | 242 | 2023-01-01 | 2025-11-20 |
| Efficacy and Safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage Endoscopic surgery, Medical management - Intracerebral Hemorrhage Basal Ganglia | Not applicable | Unknown | Southwest Hospital, China | 560 | 2022-11-18 | 2024-05-10 |
| Naltrexone in AUD Reward Drinkers XR-NTX 380 mg, intramuscular injection, Medical Management, Placebo intramuscular injection - Alcohol Use Disorder, Alcoholism | Phase 4 | Recruiting | University of Pennsylvania | 60 | 2022-03-07 | 2026-01-20 |
| Managing Non-acute Subdural Hematoma Using Liquid Materials：a Chinese Randomized Trial of MMA Treatment Onyx, Burr-hole, Medical Management - Subdural Hematoma, Non-acute | Not applicable | Unknown | Huashan Hospital | 722 | 2021-03-21 | 2024-04-30 |
| The HYsteroscopic Miscarriage MaNagement Trial: A Pilot RCT Investigating a Novel Management Pathway for RPOC Outpatient hysteroscopy, Expectant management, Medical management - Retained Products After Miscarriage | Not applicable | Completed | Birmingham Women's and Children's NHS Foundation Trust | 149 | 2021-01-31 | 2023-08-14 |
| Study on Prevention and Treatment of Atherosclerotic Cerebral Occlusive Disease With Remote Ischemic Conditioning Doctormate®+Medical Management, Medical Management - Cerebral Atherosclerosis | Not applicable | Unknown | Ji Xunming,MD,PhD | 700 | 2020-09-01 | 2020-07-14 |
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Ischemic Stroke (11) · Alcoholism (9) · Heart Failure (4) · Stroke (4) · Atrial Fibrillation (2) · Back Pain (2) · Cerebral Hemorrhage (2) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Emphysema (2) · Intracranial Hemorrhages (2) · Low Back Pain (2) · Lung Diseases (2) · Pathologic Processes (2) · Pulmonary Disease, Chronic Obstructive (2)
University of Pennsylvania (4) · CVRx, Inc. (3) · Abbott Medical Devices (2) · Integra LifeSciences Corporation (2) · Olympus Corporation of the Americas (2) · Zhongming Qiu (2) · AdventHealth (1) · Amrou Sarraj (1) · Avanos Medical (1) · Birmingham Women's and Children's NHS Foundation Trust (1) · Boston Scientific Corporation (1) · Centre Hospitalier Henri Duffaut - Avignon (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Columbia University (1) · DFINE Inc. (1)
United States (33) · Canada (10) · China (6) · Germany (5) · France (4) · Australia (3) · Italy (3) · Netherlands (3) · Spain (3) · United Kingdom (3) · Switzerland (2) · Austria (1) · Brazil (1) · Czechia (1) · Finland (1)
Amrou Sarraj, MD (2) · David Curd, MS (2) · Guangxiong Yuan (2) · Henry R Kranzler, MD (2) · J Mocco, MD, MS (2) · Tudor G Jovin, MD (2) · Abigail R. Smith, PhD (1) · Adnan Siddiqui, MD, PhD (1) · Alan J. Moskowitz, MD (1) · Alejandro Spiotta, MD (1) · Alex Hall, DHSc (1) · Alexander P. Glaser, MD (1) · Allan Brook, M.D. (1)
PMID 15850502, PMID 17962585, PMID 18784099, PMID 19032530, PMID 19953376, PMID 21983306, PMID 22322574, PMID 22439295, PMID 23131884, PMID 23747789, PMID 24268105, PMID 24831647, PMID 25982108, PMID 26011593, PMID 26483097, PMID 26682789, PMID 26758265, PMID 27627782, PMID 27920321, PMID 28065708, PMID 28238522, PMID 28396040, PMID 28465311, PMID 28611126, PMID 28878048, PMID 29129157, PMID 29540927, PMID 29705650, PMID 30538599, PMID 31303153, PMID 31365298, PMID 31563589, PMID 31744425, PMID 31915151, PMID 32562682, PMID 32616150, PMID 33870426, PMID 33992562, PMID 34049101, PMID 34281376, PMID 34282987, PMID 34727737, PMID 34850380, PMID 35122371, PMID 35229945, PMID 35450966, PMID 35739539, PMID 36762865, PMID 37407279, PMID 37526012
1OT2NS129366-01 (1), R01AA023192 (1), R01DA027405 (1), R21AA017503 (1), U01NS051483 (1), U01NS051566 (1)