61 completed, 33 unknown, 26 recruiting, 12 terminated. 121 Not applicable, 16 Phase 2, 7 Phase 1, 5 Phase 4, 3 Phase 3.
Follow Ketogenic diet: new trials by email Literature Review of Ketogenic diet trials Research Report on Ketogenic diet
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot Ketogenic diet, Exogenous Ketone Supplement - PCOS (Polycystic Ovary Syndrome) | Not applicable | Recruiting | Ohio State University | 40 | 2026-12-01 | 2026-05-08 |
| Ketogenic Diet and Neuromodulation in Treatment Resistant Depression Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 60 | 2026-10-21 | 2026-10-28 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| Effects of Ketogenic Diet on Alcohol Intoxication Ketogenic diet - Ketogenic Diet, Alcohol Drinking | Not applicable | Recruiting | University of Pennsylvania | 20 | 2026-05-14 | 2026-08-04 |
| Impact of Ketogenic Diet on Tumor Microenvironment in Patients With Breast Cancer Ketogenic diet - Breast Cancer | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 12 | 2026-04-02 | 2026-05-08 |
| Nutritional Ketosis Marfan Ketogenic diet - Marfan Syndrome, Aortic Dissection | Not applicable | Not yet recruiting | Washington University School of Medicine | 15 | 2026-03-13 | 2026-03-27 |
| Ketogenic Diet for Post-Traumatic Stress Disorder (PTSD) Ketogenic diet - Post-Traumatic Stress Disorder, PTSD | Not applicable | Completed | Bundeswehr University Munich | 6 | 2026-03-12 | 2026-08-13 |
| Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis Ketogenic diet, Carnivore (Lion) Diet - Rheumatoid Arthritis (RA), Crohn's Disease (CD) | Not applicable | Recruiting | Fuller Research Foundation | 160 | 2026-02-17 | 2026-10-05 |
| BEAM-MM - β-Hydroxybutyrate-Enhanced Adaptive Immunity in Multiple Myeloma Ketogenic diet, Ketogenic Drinks - Multiple Myeloma (MM), CAR T Cells | Not applicable | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 45 | 2026-01-30 | 2026-05-04 |
| Evaluation of the Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery Ketogenic diet, Control diet - Postoperative Cognitive Dysfunction | Not applicable | Withdrawn | University of Missouri-Columbia | 2026-01-15 | 2026-06-02 | |
| Ketogenic Dietary Intervention in Men With Mild-to-Moderate COPD Ketogenic diet, Standard Dietary Advice - Chronic Obstructive Pulmonary Disease (COPD) | Not applicable | Completed | Agri Ibrahim Cecen University | 34 | 2026-01-01 | 2026-08-07 |
| Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients? Ketogenic diet, Isocaloric diet, Ketone ester supplementation - Lymphedema, Ketogenic Dieting | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 81 | 2025-10-01 | 2025-12-03 |
| Ketogenic Intervention for Bipolar Depression Ketogenic Diet - Bipolar Depression | Not applicable | Recruiting | Mayo Clinic | 30 | 2025-08-12 | 2026-08-17 |
| Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies Ketogenic diet - Developmental and Epileptic Encephalopathies, Epileptic Spasms | Phase 1 | Terminated | Heather Olson | 1 | 2025-08-11 | 2026-10-14 |
| Managing Pasireotide-associated Hyperglycaemia in Acromegaly With Ketogenic Diet Ketogenic diet, Diabetes Medication - Acromegaly Due to Pituitary Adenoma, Hyperglycemia | Not applicable | Recruiting | Leiden University Medical Center | 30 | 2025-07-29 | 2026-10-08 |
| Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma Ketogenic diet, 2-[18F]FDG PET/CT - Lepidic-Predominant Lung Adenocarcinoma, Lung Adenocarcinoma | Not applicable | Recruiting | Fondazione del Piemonte per l'Oncologia | 30 | 2025-07-03 | 2026-03-20 |
| A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia Whole Food Ketogenic Diet, Whole Food Diet - Idiopathic Hypersomnia, Narcolepsy Type 1 (NT 1) | Not applicable | Recruiting | University of Sydney | 30 | 2025-06-23 | 2025-08-27 |
| Interventions for Weight Regain After Bariatric Surgery Diet, Ketogenic diet, Fasting - Obese Patients With Bariatric Surgery, Obese Patients (BMI ≥ 30 kg/m²) | Not applicable | Completed | Medipol University | 43 | 2025-05-12 | 2025-08-01 |
| The Causal Role of Ketone Bodies in Obesity-associated Disease Prevention - Combining Genetic Epidemiology With a Randomised Trial to Infer Causality Ketone Monoester (KE), Ketogenic diet - Nutrition, Obesity and Overweight | Not applicable | Completed | University of Bath | 69 | 2025-05-06 | 2026-06-15 |
| Single-Center Trial on Ketogenic Diet and Immunotherapy in Advanced Cancer This Study Evaluates the Safety and Effects of a Ketogenic Diet (KD) Combined With Immunotherapy in Adults With Advanced Melanoma, cSCC, or RCC. Ketogenic diet - Cancer, Immunotherapy | Phase 1 / Phase 2 | Not yet recruiting | Rabin Medical Center | 60 | 2025-04-01 | 2025-03-26 |
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Obesity (20) · Epilepsy (13) · Ketosis (11) · Drug Resistant Epilepsy (7) · Glioblastoma (7) · Overweight (7) · Bipolar Disorder (6) · Alzheimer Disease (5) · Fasting (4) · Insulin Resistance (4) · Neoplasms (4) · Non-alcoholic Fatty Liver Disease (4) · Seizures (4) · Brain Neoplasms (3) · Breast Neoplasms (3)
University of Padova (6) · Ohio State University (5) · Johns Hopkins University (4) · Mid-Atlantic Epilepsy and Sleep Center, LLC (4) · University of Roma La Sapienza (4) · Washington University School of Medicine (4) · All India Institute of Medical Sciences (3) · IRCCS National Neurological Institute "C. Mondino" Foundation (3) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (3) · Oslo University Hospital (3) · University of Cologne (3) · Weill Medical College of Cornell University (3) · Mclean Hospital (2) · Shriners Hospitals for Children (2) · University of Alabama at Birmingham (2)
United States (63) · Italy (19) · China (7) · Germany (6) · Norway (5) · United Kingdom (5) · India (4) · Canada (3) · Mexico (3) · Turkey (Türkiye) (3) · Egypt (2) · France (2) · Netherlands (2) · Poland (2) · Australia (1)
Antonio Paoli, MD (4) · Bryan G. Allen, MD, PhD (3) · Pavel Klein, M.D. (3) · Corinde Wiers, Ph.D. (2) · Henry Kranzler, MD (2) · Howard Fine, MD (2) · Laura A Velazquez Villegas, PhD (2) · Ryan W Lee, MD (2) · Virginie-Anne Chouinard, MD (2) · Adrian Soto, Ph.D, MD. (1) · Adrienne C Scheck, PhD (1) · Amr Abbassy, MD (1) · Andrew Cluster, M.D. (1) · Angela Sinner, DO (1)
PMID 40043832, PMID 25156013, PMID 28437190, PMID 33292598, PMID 12724520, PMID 1387700, PMID 15728303, PMID 18456557, PMID 19049574, PMID 20430626, PMID 23217257, PMID 23291218, PMID 23743570, PMID 24291541, PMID 25005809, PMID 25149833, PMID 25232151, PMID 25597016, PMID 25666556, PMID 25806103, PMID 26109579, PMID 26855664, PMID 27245682, PMID 27525031, PMID 28049662, PMID 28446244, PMID 28467922, PMID 28476546, PMID 28877457, PMID 28931850, PMID 29769827, PMID 29874567, PMID 29984492, PMID 30137481, PMID 30174308, PMID 30200193, PMID 30931426, PMID 31228957, PMID 31311141, PMID 31725105, PMID 31737350, PMID 31898518, PMID 32366293, PMID 32437658, PMID 32588435, PMID 32694649, PMID 32761191, PMID 32773571, PMID 32922055, PMID 33367782
R21CA161182 (2), 2018 (1), 2025 (1), K99AA031746 (1), P30CA086862 (1), R21AA031088 (1), U54NS065768 (1)