31 completed, 8 terminated, 2 unknown, 2 withdrawn. 24 Phase 4, 10 Phase 3, 7 Not applicable, 2 Phase 2, 1 Early Phase 1.
Follow IV acetaminophen: new trials by email Literature Review of IV acetaminophen trials Research Report on IV acetaminophen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Acetaminophen and Ketorolac for Pain Management During Extracorporeal Shockwave Lithotripsy IV midazolam, IV fentanyl, IV acetaminophen - Extracorporeal Shockwave Lithotripsy | Phase 4 | Enrolling by invitation | Horizon Health Network | 266 | 2026-04-01 | 2026-04-13 |
| Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption IV Acetaminophen - Post Operative Analgesia, Opioid Consumption, Postoperative | Phase 4 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 140 | 2025-04-28 | 2025-04-11 |
| Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure IV acetaminophen, IV fentanyl - Women Undergoing Oocyte Retrieval Procedures | Not applicable | Completed | Tel-Aviv Sourasky Medical Center | 100 | 2021-12-05 | 2023-03-29 |
| PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients IV acetaminophen, Placebo - Delirium in Old Age, Delirium | Phase 3 | Completed | Beth Israel Deaconess Medical Center | 901 | 2020-08-11 | 2026-10-22 |
| Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval IV Acetaminophen, PO Acetaminophen, Placebo IV Acetaminophen - Infertility, Female, Pain, Postoperative | Phase 4 | Completed | Massachusetts General Hospital | 161 | 2019-09-01 | 2022-05-26 |
| IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients IV acetaminophen, IV placebo, hydromorphone - Acute Pain | Phase 3 | Completed | Albert Einstein College of Medicine | 162 | 2018-11-27 | 2022-03-02 |
| Preoperative IV Versus Oral Acetaminophen IV Acetaminophen, PO Acetaminophen, PO Placebo - Pain, Postoperative | Phase 4 | Completed | TriHealth Inc. | 120 | 2018-04-01 | 2019-05-14 |
| Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery IV acetaminophen, Fentanyl, PO acetaminophen - Emergence Agitation, Pain | Early Phase 1 | Completed | Nemours Children's Clinic | 143 | 2017-10-03 | 2020-01-18 |
| Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH IV acetaminophen, Oral acetaminophen, Oral placebo - Subarachnoid Hemorrhage, Stroke | Phase 4 | Terminated | Milton S. Hershey Medical Center | 3 | 2017-01-05 | 2019-04-10 |
| Pain Control in Elderly Hip Fracture Patients: Is Intravenous Acetaminophen Superior to Oral Administration? IV Acetaminophen, PO Acetaminophen - Hip Fracture | Phase 4 | Terminated | Corewell Health West | 1 | 2016-12-01 | 2023-09-28 |
| Maxigesic IV Phase 3 Bunionectomy Study Maxigesic IV, IV Acetaminophen, IV Ibuprofen - Post Operative Pain | Phase 3 | Completed | AFT Pharmaceuticals, Ltd. | 276 | 2016-10-26 | 2021-07-06 |
| Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain IV acetaminophen, Oral acetaminophen, Morphine - Acute Pain, Postoperative | Phase 4 | Terminated | Mallinckrodt | 1 | 2016-04-27 | 2019-11-19 |
| Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen Oral Acetaminophen, IV Acetaminophen, IV Morphine - Pain | Phase 4 | Completed | Mallinckrodt | 50 | 2016-02-01 | 2020-02-05 |
| IV Acetaminophen in Children Undergoing Palatoplasty IV acetaminophen, Placebo - Cleft Palate | Phase 2 | Withdrawn | Nationwide Children's Hospital | 2015-12-01 | 2016-03-08 | |
| Equality Study of Ofirmev vs Oral Acetaminophen IV acetaminophen, oral acetaminophen - Pain, Postoperative | Phase 4 | Unknown | Babiash, Kimberly H., M.D. | 114 | 2015-12-01 | 2015-01-28 |
| Efficacy of Acetaminophen in Posterior Fossa Surgery IV acetaminophen, normal saline - Arnold-Chiari Malformation, Posterior Fossa Tumors | Phase 2 | Withdrawn | Children's National Research Institute | 2015-11-01 | 2021-04-08 | |
| IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy IV acetaminophen, placebo - Pain | Phase 4 | Completed | University of Pittsburgh | 183 | 2015-02-01 | 2018-06-13 |
| PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement Oral acetaminophen, IV acetaminophen - Post-op Pain | Phase 4 | Completed | Kettering Health Network | 515 | 2014-09-01 | 2017-07-24 |
| Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure IV Ibuprofen, IV Acetaminophen, Intravenous placebo/Intravenous placebo - Symptomatic Uterine Fibroids and Adenomyosis | Phase 4 | Completed | University of California, Los Angeles | 40 | 2014-08-01 | 2018-06-08 |
| Comparison of Exparel to Bupivacaine With Dexamethasone in TAP Block Bupivacaine Extended-Release Liposome Injection (Exparel), Bupivacaine and Dexamethasone Injection, IV Acetaminophen - Pain | Phase 4 | Terminated | Colette Curtis MD | 9 | 2014-07-01 | 2017-08-11 |
Showing 20 of 45. Sign in to see all of them.
Pain, Postoperative (18) · Pain (15) · Acute Pain (4) · Fever (4) · Vomiting (3) · Agnosia (2) · Patient Satisfaction (2) · Adenomyosis (1) · Airway Obstruction (1) · Arnold-Chiari Malformation (1) · Cleft Palate (1) · Constipation (1) · Coronary Artery Disease (1) · Deglutition Disorders (1) · Delirium (1)
Mallinckrodt (9) · TriHealth Inc. (3) · The University of Texas Health Science Center, Houston (2) · AFT Pharmaceuticals, Ltd. (1) · Albert Einstein College of Medicine (1) · Aultman Health Foundation (1) · Babiash, Kimberly H., M.D. (1) · Beth Israel Deaconess Medical Center (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Children's National Research Institute (1) · Colette Curtis MD (1) · Corewell Health West (1) · Gundersen Lutheran Medical Foundation (1) · Halina M Zyczynski, MD (1) · Hartford Hospital (1)
United States (41) · Canada (2) · Israel (1)
Andrew R. Fras, MD (1) · Balachundhar Subramaniam, MD, MPH (1) · Carlos A Archilla, MD (1) · Catrina Crisp, MD, MSc (1) · Cheryl H Hoffman, MD (1) · Christina Lee, B.Sc. (1) · Colette Curtis, MD (1) · Davide Cattano, MD, PhD (1) · Donna Lambers, MD (1) · Elena Farladansky, MD (1) · Eugene Viscusi, MD (1) · Franck Vandenbroucke-Menu, MD (1) · Frank J Overdyk, MD (1) · Gildasio De Oliveira, MD (1)
PMID 21353105, PMID 11472277, PMID 15978146, PMID 21114616, PMID 27182992, PMID 28230615, PMID 28455085, PMID 28542675, PMID 29214506, PMID 30741813, PMID 31447129, PMID 31448420, PMID 32156175, PMID 33692183, PMID 34499349, PMID 34548165, PMID 38883767, PMID 39446661, PMID 40451048, PMID 41980267
2025 (1), R01AG065554 (1)