15 completed, 4 unknown, 2 withdrawn, 1 active not recruiting. 6 Early Phase 1, 5 Not applicable, 5 Phase 2, 4 Phase 3, 3 Phase 1.
Follow Hyaluronidase: new trials by email Literature Review of Hyaluronidase trials Research Report on Hyaluronidase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Hyaluronidase in Different Doses Added to Bupivacaine on TAB Block Quality During CS Hyaluronidase - Tab Block Qaulity | Early Phase 1 | Not yet recruiting | Benha University | 120 | 2025-03-01 | 2025-02-21 |
| Hyaluronidase Assisted Subcutaneous Infusion hyaluronidase, Placebo - Healthy | Phase 3 | Completed | Shanghai Bao Pharmaceuticals Co., Ltd. | 45 | 2024-03-28 | 2024-09-23 |
| Hyaluronidase Via LADD Scleroderma-induced Microstomia Hyaluronidase, CO2 laser - Microstomia, Scleroderma | Early Phase 1 | Completed | University of Nebraska | 3 | 2024-03-01 | 2026-04-15 |
| Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section Hyaluronidase, Bupivacaine Injection - Pain, Postoperative | Not applicable | Completed | Benha University | 114 | 2023-05-15 | 2025-09-19 |
| Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma Polatuzumab vedotin (PV), Rituximab, Hyaluronidase - Diffuse Large B-cell Lymphoma | Phase 2 | Terminated | UNC Lineberger Comprehensive Cancer Center | 5 | 2023-02-17 | 2026-04-16 |
| Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal Surgeries Dexmedetomidine, Neostigmine, Saline - Vitreoretinal Surgeries, Local Anesthesia | Early Phase 1 | Completed | Ain Shams University | 81 | 2023-01-20 | 2024-07-15 |
| Use of Tranexamic Acid in Facial Fillers Tranexamic acid, Saline, Hyaluronic acid - Injection Site Bruising | Phase 4 | Withdrawn | University of Wisconsin, Madison | 2022-07-01 | 2022-07-26 | |
| Peripheral Modulation of Muscle Stiffness and Spasticity Hyaluronidase, Placebo - Muscle Spasticity | Phase 2 | Active not recruiting | Johns Hopkins University | 56 | 2021-10-11 | 2026-06-30 |
| Effectiveness of Adding Hyaluronidase to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block Hyaluronidase - Postoperative Pain | Phase 2 / Phase 3 | Unknown | Sohag University | 40 | 2021-09-10 | 2021-10-27 |
| Ultrasound Guided Erector Spinae Plane Block in Breast Surgery Local anesthetic, Hyaluronidase - Postoperative Pain | Not applicable | Unknown | Assiut University | 60 | 2018-05-19 | 2020-04-09 |
| Effect of Hyaluronidase on Intraocular Pressure Hyaluronidase - Intraocular Pressure Low | Not applicable | Unknown | Assiut University | 50 | 2017-09-01 | 2017-08-30 |
| ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients Hylase, Insulin, saline - Treatment Resistant Carpal Tunnel in RA Patients | Not applicable | Unknown | Assiut University | 90 | 2017-07-01 | 2018-07-13 |
| Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study Hyaluronidase, Lidocaine, Bupivacaine - Addition of Hyalase to Local Anesthetic in Scalp Block | Early Phase 1 | Completed | Cairo University | 64 | 2017-01-24 | 2018-04-27 |
| The Use of a Recombinant DNA-based Hyaluronidase to Dissolve Fixed Amounts of Hyaluronic Acid Dermal Fillers Hylenex - Dermal Filler | Phase 1 | Completed | Steve Yoelin M.D. Medical Associates, Inc. | 15 | 2016-01-01 | 2017-05-16 |
| Hylenex-Assisted Resuscitation in Kenya (HARK) Trial for the Management of Dehydration Hyaluronic Acid - Dehydration | Phase 2 | Completed | Massachusetts General Hospital | 51 | 2014-10-01 | 2019-03-07 |
| Hyaluronidase Effect on Infusion Set Life Hyaluronidase, Control - Type 1 Diabetes Mellitus | Phase 1 | Completed | Stanford University | 30 | 2014-07-01 | 2019-10-11 |
| Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy ePID closed loop system, hyaluronidase, Lispro-PH20 - Type 1 Diabetes | Early Phase 1 | Completed | Yale University | 13 | 2013-09-01 | 2022-05-24 |
| Reducing and Removing Hyaluronic Acid Filler With Hyaluronidase Hyaluronidase - Drug Safety | Early Phase 1 | Completed | Northwestern University | 5 | 2012-10-01 | 2026-07-01 |
| Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP) Hyaluronidase, Histamine, Saline - Allergic Skin Reaction | Phase 2 | Completed | Amphastar Pharmaceuticals, Inc. | 253 | 2012-09-01 | 2017-01-20 |
| Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics 3.6mL 2% Mepivacaine with 1:100,000 epinephrine, Lower Third Molar Extraction, Hyaluronidase - Cardiac Arrhythmias | Phase 4 | Completed | Mauricio Jose Tornelli | 20 | 2007-10-01 | 2012-11-02 |
Showing 20 of 24. Sign in to see all of them.
Pain, Postoperative (3) · Diabetes Mellitus, Type 1 (2) · Arrhythmias, Cardiac (1) · Cardiovascular Diseases (1) · Cerebral Palsy (1) · Coronary Disease (1) · Dehydration (1) · Diabetes Mellitus (1) · Diabetic Retinopathy (1) · Heart Diseases (1) · Hyperglycemia (1) · Hypersensitivity (1) · Lymphoma, Large B-Cell, Diffuse (1) · Microstomia (1) · Muscle Spasticity (1)
Assiut University (3) · Benha University (2) · Ain Shams University (1) · Amphastar Pharmaceuticals, Inc. (1) · Bausch & Lomb Incorporated (1) · Baxter Healthcare Corporation (1) · Cairo University (1) · Duke University (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Mauricio Jose Tornelli (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Northwestern University (1) · Shanghai Bao Pharmaceuticals Co., Ltd. (1) · Sohag University (1)
United States (9) · Egypt (6) · Brazil (2) · Australia (1) · China (1) · Hungary (1) · Italy (1) · Kenya (1) · Netherlands (1) · Poland (1) · South Africa (1) · Spain (1) · United Kingdom (1)
Ahmed M Afifi, MD (1) · Allan Jaffee (1) · Brett D. Nelson, MD,MPH,DTM&H (1) · Bruce A Buckingham, MD (1) · Christopher Dittus, DO, MPH (1) · Eda Cengiz, MD, MHS (1) · Eugene Braunwald (1) · George E Harb, MD (1) · Gustavo F Prado, PhD (1) · Helena R Tornelli, MD, S (1) · James Willerson (1) · Lisa R Grillone, PhD (1) · Manal Hassanien, MD (1) · Maria A Borsatti, PhD (1) · Murad Alam, MD (1)
PMID 18441312, PMID 19947907, PMID 27222506, PMID 28678057, PMID 29710212, PMID 30219027, PMID 41935547