13 completed, 2 not yet recruiting, 2 terminated, 1 active not recruiting. 7 Phase 3, 4 Not applicable, 4 Phase 2, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 7 |
| Not applicable | 4 | Completed 1, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 4 | 3 | Completed 2, Not yet recruiting 1 |
Follow Estrogen Replacement Therapy: new trials by email Literature Review of Estrogen Replacement Therapy trials Research Report on Estrogen Replacement Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| Effect of Postural Correction Exercises on Pelvic Floor Dysfunction in Postmenopausal Osteoporotic Women Estrogen replacement therapy, General advice, Postural correction exercise program - Osteoporosis, Postmenopausal | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-09-01 | 2026-09-08 |
| An Observational Study to Learn How Mirena and Other Progestogen Treatments Are Used for Endometrial Protection in Women 40+ With a Uterus in the United States Receiving Estrogen Therapy, and Their Respective Health Outcomes Estrogen therapy, Mirena levonorgestrel-releasing intrauterine system, Other progestogen therapy - Estrogen Therapy | Active not recruiting | Bayer | 456000 | 2026-08-31 | 2026-10-19 | |
| Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility estrogen therapy, Sildenafil, Clomiphene Citrate 50mg - Subfertility, Female | Phase 4 | Completed | Beni-Suef University | 148 | 2021-01-15 | 2023-04-28 |
| Estrogen Therapy in Non-severe COVID-19 Patients Estrogen Therapy - Covid-19 | Not applicable | Unknown | CMN "20 de Noviembre" | 44 | 2020-10-01 | 2023-04-05 |
| An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial Cancer Sodium Cridanimod, progestin therapy - Endometrial Cancer | Phase 2 | Terminated | Xenetic Biosciences, Inc. | 25 | 2017-06-14 | 2022-06-07 |
| The Effects of Estrogen on Artificial Endometrium oral estrogen replacement therapy, Estradiol transdermal patch - Infertility | Not applicable | Completed | Memorial Sisli Hospital, Istanbul | 317 | 2017-05-01 | 2018-11-06 |
| ELITE: Early Versus Late Intervention Trial With Estradiol 17B-estradiol, Placebo - Atherosclerosis | Phase 2 | Completed | University of Southern California | 643 | 2004-07-01 | 2023-01-18 |
| Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia Estrogen Replacement Therapy, Zolpidem, placebo - Sleep Initiation and Maintenance Disorders, Depression | Phase 4 | Completed | Hadine Joffe, MD | 86 | 2003-08-01 | 2014-05-26 |
| Alzheimer's Disease: Therapeutic Potential of Estrogen Transdermal estradiol, Medroxyprogesterone, Placebo Patch - Alzheimer Disease | Phase 2 / Phase 3 | Completed | University of Wisconsin, Madison | 42 | 2001-09-01 | 2018-08-23 |
| Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery Estrogen Replacement Therapy, Surgery - Coronary Disease, Cardiovascular Diseases | Not applicable | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 334 | 2001-06-01 | 2016-07-29 |
| Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections Estrogen therapy - Atherosclerosis, Chlamydia Infections | Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 80 | 1999-05-01 | 2008-03-04 |
| Women's Angiographic Vitamin and Estrogen Trial (WAVE) estrogen replacement therapy, estrogens, conjugated, progesterone - Cardiovascular Diseases, Coronary Arteriosclerosis | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1996-08-01 | 2016-07-12 | |
| The Women's Health Initiative Memory Study (The WHIMS Study) Estrogen hormone therapy, Estrogen plus progesterone hormone therapy, Placebo - Dementia Syndromes | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 7525 | 1996-01-01 | 2015-10-19 | |
| Postmenopausal Hormone Therapy in Unstable Angina estrogen replacement therapy, estrogens, progesterone - Angina, Unstable, Cardiovascular Diseases | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1995-07-01 | 2016-02-18 | |
| Women's Estrogen/Progestin Lipid Lowering Hormone Atherosclerosis Regression Trial (WELL-HART) estrogen replacement therapy, hormone replacement therapy, estradiol - Cardiovascular Diseases, Coronary Disease | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1995-03-01 | 2016-07-12 | |
| Estrogen Replacement and Atherosclerosis (ERA) in Older Women estrogen replacement therapy, hormone replacement therapy, estrogens - Cardiovascular Diseases, Coronary Arteriosclerosis | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1994-08-01 | 2016-03-16 | |
| Postmenopausal Estrogen/Progestin Interventions (PEPI) estrogens, conjugated, medroxyprogesterone, progesterone - Bone Diseases, Cardiovascular Diseases | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1987-09-01 | 2016-05-13 | |
| Women's Health Initiative (WHI) hormone replacement therapy, estrogens, progestins - Bone Diseases, Breast Neoplasms | Phase 3 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 2016-04-15 |
Cardiovascular Diseases (8) · Coronary Disease (7) · Heart Diseases (7) · Myocardial Ischemia (5) · Coronary Artery Disease (3) · Osteoporosis (3) · Atherosclerosis (2) · Bone Diseases (2) · Endometrial Neoplasms (2) · Alzheimer Disease (1) · Angina, Unstable (1) · Breast Neoplasms (1) · COVID-19 (1) · Chlamydia Infections (1) · Colonic Neoplasms (1)
National Heart, Lung, and Blood Institute (NHLBI) (9) · Bayer (1) · Beni-Suef University (1) · CMN "20 de Noviembre" (1) · Cairo University (1) · Hadine Joffe, MD (1) · Hospital Universitari de Bellvitge (1) · Memorial Sisli Hospital, Istanbul (1) · University of Southern California (1) · University of Wisconsin, Madison (1) · Xenetic Biosciences, Inc. (1)
United States (8) · Egypt (2) · Mexico (1) · Turkey (Türkiye) (1)
Charles W. Hogue, Jr., MD (1) · Cindy Bandala, MD MSc PhD (1) · Curtis Lockshin, PhD (1) · David Herrington (1) · Hadine Joffe, MD, MSC (1) · Hatem M Hasan, As.professor (1) · Howard Hodis (1) · Howard N. Hodis, M.D. (1) · Joel Verter (1) · Jorge Garcia Fernandez (1)
PMID 23480899, PMID 16467232, PMID 16467233, PMID 16467234, PMID 16481635, PMID 16481636, PMID 16609086, PMID 16880313, PMID 17329508, PMID 17341712, PMID 17405972, PMID 17502530, PMID 17582069, PMID 17925539, PMID 18235052, PMID 18299491, PMID 18319414, PMID 18489937, PMID 18502208, PMID 18640325, PMID 18663162, PMID 19001202, PMID 19005970, PMID 19193613, PMID 19204221, PMID 19221190, PMID 19224775, PMID 19402886, PMID 19403636, PMID 19423530, PMID 19474140, PMID 19767090, PMID 19822825, PMID 19861516, PMID 19996872, PMID 20056625, PMID 20157135, PMID 20160160, PMID 20181812, PMID 20354566, PMID 20433539, PMID 20667078, PMID 20833684, PMID 20884191, PMID 20937929, PMID 20959578, PMID 20980487, PMID 21177798, PMID 21416508, PMID 21467283
K23MH066978 (1), N01HV68165 (1), N01HV68166 (1), N01HV68167 (1), N01HV68168 (1), N01HV68169 (1), N01HV68170 (1), N01WH44221 (1), R01AG017196 (1), R01AG024154 (1), R01HL050839 (1), R01HL064600 (1), U01HL040232 (1), U01HL049488 (1)