7 completed, 4 recruiting, 3 active not recruiting, 1 enrolling by invitation. 8 Not applicable, 3 Phase 2, 3 Phase 4, 2 Phase 3, 1 Phase 1.
Follow Electroconvulsive therapy (ECT): new trials by email Literature Review of Electroconvulsive therapy (ECT) trials Research Report on Electroconvulsive therapy (ECT)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide | Not applicable | Not yet recruiting | University of Iowa | 50 | 2026-12-01 | 2025-05-20 |
| Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy Flumazenil, Electroconvulsive therapy (ECT) - Depression - Major Depressive Disorder, Bipolar Disorder (BD) | Not applicable | Recruiting | Anders Jørgensen | 145 | 2026-01-15 | 2026-06-01 |
| Management of Catatonic Features in Adolescents With Profound Autism Intranasal Midazolam (Benzodiazepine Challenge Test), Oral Clonazepam, Electroconvulsive Therapy (ECT) - Autism Spectrum Disorder, Catatonia | Not applicable | Active not recruiting | Tanta University | 30 | 2026-01-01 | 2026-03-27 |
| Effects of Repeated Electroconvulsive Therapy Sessions on Anesthetic Requirements Electroconvulsive Therapy (ECT) - Electroconvulsive Therapy | Completed | Izmir City Hospital | 35 | 2025-12-20 | 2026-10-08 | |
| Treatment Response In ECT Patients Electroconvulsive Therapy (ECT) - Major Depression, Bipolar Affective Disorder | Active not recruiting | Nurdan Sağbaş | 65 | 2025-05-20 | 2026-03-13 | |
| Magnetic Seizure Therapy for Schizophrenia - Trial Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT) - Treatment Resistant Schizophrenia, Schizophrenia | Not applicable | Recruiting | Centre for Addiction and Mental Health | 80 | 2025-04-22 | 2026-02-03 |
| Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD) magnetic seizure therapy (MST), electroconvulsive therapy (ECT) - Bipolar Disorder | Not applicable | Recruiting | Joao L. DeQuevedo | 60 | 2024-08-24 | 2025-12-03 |
| Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan Subanesthetic dose intravenous ketamine (KET), Electroconvulsive therapy (ECT) - Acute Suicidal Depression (ASD) | Phase 4 | Enrolling by invitation | Brigham and Women's Hospital | 1500 | 2023-10-01 | 2025-12-15 |
| Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA Electroconvulsive therapy (ECT) - Depressive Disorder, Major | Active not recruiting | Radboud University Medical Center | 220 | 2022-01-01 | 2026-04-21 | |
| Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD) Electroconvulsive Therapy (ECT) - Alzheimer Dementia, Agitation,Psychomotor | Not applicable | Completed | Brent Forester | 41 | 2021-01-28 | 2026-07-30 |
| University of Iowa Interventional Psychiatry Service Patient Registry Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine - Treatment Resistant Depression, Major Depressive Episode | Recruiting | Mark Niciu | 1000 | 2020-11-02 | 2026-03-03 | |
| Use of Electroconvulsive Therapy to Treat Self-Injurious Behavior in Adults With Autism Spectrum Disorders Electroconvulsive Therapy (ECT) - Autism Spectrum Disorder, Self-Injurious Behavior | Not applicable | Terminated | Eastern Virginia Medical School | 1 | 2019-03-15 | 2021-06-24 |
| Efficacy of Convulsive Therapies for Bipolar Depression Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT) - Bipolar Disorder, Bipolar Depression | Not applicable | Completed | Centre for Addiction and Mental Health | 76 | 2018-09-21 | 2024-11-04 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression Etomidate, Ketamine, Hyperventilation - Depression | Phase 4 | Unknown | University of Manitoba | 48 | 2016-09-01 | 2016-10-21 |
| The Antidepressant Effect of Repetitive Transcranial Magnetic Stimulation (rTMS)Compared to ECT Right prefrontal lowfrequency ( 1 hz) rTMS., Electroconvulsive therapy (ECT) - Depressive Disorder | Phase 2 / Phase 3 | Completed | University of Aarhus | 60 | 2002-05-01 | 2008-07-02 |
| Electroconvulsive Therapy in Clozapine Refractory Schizophrenia Electroconvulsive Therapy (ECT), Clozapine - Schizophrenia | Phase 1 / Phase 2 | Completed | Northwell Health | 39 | 2000-12-01 | 2017-05-15 |
| Comparing the Effects of Four Types of Electroconvulsive Therapy on Mood and Thinking in People With Depression Electroconvulsive Therapy (ECT) - Depression | Phase 4 | Completed | New York State Psychiatric Institute | 180 | 1998-12-01 | 2014-08-18 |
Depressive Disorder, Major (8) · Bipolar Disorder (5) · Depression (5) · Depressive Disorder (3) · Autism Spectrum Disorder (2) · Depressive Disorder, Treatment-Resistant (2) · Mental Disorders (2) · Schizophrenia (2) · Suicidal Ideation (2) · Alzheimer Disease (1) · Catatonia (1) · Dementia (1) · Epilepsy, Rolandic (1) · Hyperventilation (1) · Nervous System Diseases (1)
Centre for Addiction and Mental Health (2) · Anders Jørgensen (1) · Bo Hu (1) · Brent Forester (1) · Brigham and Women's Hospital (1) · Eastern Virginia Medical School (1) · Izmir City Hospital (1) · Joao L. DeQuevedo (1) · Mark Niciu (1) · New York State Psychiatric Institute (1) · Northwell Health (1) · Nurdan Sağbaş (1) · Radboud University Medical Center (1) · Tanta University (1) · University of Aarhus (1)
United States (8) · Canada (4) · Denmark (2) · Turkey (Türkiye) (2) · Egypt (1) · Netherlands (1)
Amit Anand, MD (2) · Brent P Forester, MD, MSc (1) · Daniel Blumberger, M.D., MSc. (1) · Daniel Blumberger, MD, MSc (1) · George Petrides, MD (1) · Georgios Petrides, MD (1) · Harold A. Sackeim, PhD (1) · Ian McIntyre, MD, MSc (1) · Joao L. De Quevedo, MD, PhD (1) · Mark J Niciu, M.D., Ph. D. (1) · Michael Harrington, MD (1) · Nicholas T Trapp, M.D., M.S. (1) · Nicholas Trapp, MD (1)
PMID 19756236, PMID 20351570, PMID 30572160, PMID 34131914, PMID 37224232, PMID 40900112
2025 (1), R01MH035636 (1), R01MH060390 (1)