28 completed, 2 unknown, 1 terminated. 19 Not applicable, 5 Phase 3, 3 Phase 2, 2 Early Phase 1, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 18, Unknown 1 |
| Phase 3 | 5 | Completed 4, Unknown 1 |
| Phase 2 | 3 | Completed 3 |
| Early Phase 1 | 2 | Completed 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 1 | Terminated 1 |
Follow E-cigarette: new trials by email Literature Review of E-cigarette trials Research Report on E-cigarette
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers. E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms - Cigarette Smoking Behavior, E-Cigarette Use | Not applicable | Completed | Thomas Jefferson University | 44 | 2025-08-05 | 2026-10-27 |
| E-cigarette Switching Older Adults E-cigarette, Control/Standard Advice - Tobacco Use, Opioid Use Disorder | Not applicable | Completed | University of Maryland, Baltimore | 36 | 2024-11-25 | 2026-07-10 |
| Effectiveness of Different THR Products in Adult Population E-Cigarette, Nicotine patch - Smoking Cessation | Phase 3 | Unknown | Foundation for a Smoke Free World INC | 258 | 2024-06-01 | 2023-11-21 |
| E-cigarettes as a Harm Reduction Strategy E-cigarette - Smoking | Not applicable | Completed | Prisma Health-Upstate | 30 | 2023-06-20 | 2024-10-31 |
| Quit or Switch: E-cigarette Study e-cigarette, Nicotine patch, Nicotine lozenge - Tobacco Use | Not applicable | Completed | Medical University of South Carolina | 30 | 2022-08-01 | 2024-04-26 |
| Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes E-Cigarette, Financial Incentives - Chronic Obstructive Pulmonary Disease, Chronic Bronchitis | Phase 2 | Completed | University of Vermont | 21 | 2022-04-28 | 2024-02-08 |
| The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette Bupropion, Zonisamide, Placebo bupropion - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 180 | 2021-12-14 | 2026-02-06 |
| The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment E-cigarette - Tobacco Smoking, Psychiatric Disorders | Not applicable | Unknown | Fordham University | 50 | 2020-12-12 | 2023-09-18 |
| Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2 E-cigarette - Electronic Cigarette Use, Cigarette Smoking | Not applicable | Completed | University of Southern California | 461 | 2020-08-25 | 2023-07-25 |
| Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes Zonisamide, Bupropion, Halo G6 e-cigarette - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 26 | 2020-05-27 | 2022-04-13 |
| The Acute Effects of E-cigarette Inhalation on Vascular Function, Microcirculation and Thrombosis e-cigarette - E-cigarette Use, Microcirculation | Not applicable | Completed | Karolinska Institutet | 22 | 2019-12-05 | 2020-03-19 |
| Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction Varenicline, e-cigarette - Smoking Cessation, Harm Reduction | Phase 2 / Phase 3 | Completed | Rose Research Center, LLC | 25 | 2019-11-19 | 2022-02-24 |
| ECigs, Inflammation and Oxidative Stress e-cigarette, empty (-cigarette sham control) - E-cigarettes, Oxidative Stress, Inflammation | Not applicable | Completed | University of California, Los Angeles | 148 | 2019-02-08 | 2023-10-04 |
| Effects of e-Cigarettes on Perceptions and Behavior e-Cigarette - Electronic Cigarettes | Not applicable | Completed | University of Southern California | 45 | 2019-02-01 | 2023-07-11 |
| Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette - Cigarette Smoker, Current Every Day Smoker | Early Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 66 | 2018-09-17 | 2026-04-23 |
| Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants E-cigarette, P4M3-1.7%, P4M3-1.7%LA - Vaping, Nicotine Absorption | Not applicable | Completed | Philip Morris Products S.A. | 15 | 2017-07-11 | 2019-11-22 |
| Vascular Effects of a Single Bout of Electronic Cigarette Use E-cigarette, Nicotine 0%, Menthol Inhalant Product - Arterial Stiffness | Phase 1 | Completed | University of Texas at Austin | 16 | 2017-04-28 | 2018-10-11 |
| E-cigarettes and Cardiovascular Function Electronic Cigarette and behavioural change support., Nicotine-Free Electronic Cigarette and behavioural change support., Nicotine Replacement Therapy and behavioural change support. - Smoking Cessation, Cardiovascular Diseases | Not applicable | Completed | Sheffield Hallam University | 248 | 2017-04-24 | 2021-07-12 |
| Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study E-cigarette, Sham, Hyperpolarized 3-Helium - Pulmonary Disease, Chronic Obstructive, E-cigarettes | Early Phase 1 | Completed | Columbia University | 12 | 2017-03-01 | 2020-10-22 |
| The Appeal and Impact of E-cigarettes in Smokers With SMI E-cigarette - Tobacco Dependence, Schizophrenia | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 240 | 2017-03-01 | 2021-03-29 |
Showing 20 of 31. Sign in to see all of them.
Vaping (20) · Smoking Cessation (9) · Smoking (3) · Tobacco Smoking (3) · Tobacco Use Disorder (3) · Cigarette Smoking (2) · Pulmonary Disease, Chronic Obstructive (2) · Schizophrenia (2) · Tobacco Use (2) · Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome (1) · Bipolar Disorder (1) · Bronchitis, Chronic (1) · Cardiovascular Diseases (1) · Emphysema (1) · Harm Reduction (1)
Rose Research Center, LLC (3) · University of Southern California (3) · Ohio State University Comprehensive Cancer Center (2) · Columbia University (1) · Creighton University (1) · Dartmouth-Hitchcock Medical Center (1) · Fordham University (1) · Foundation for a Smoke Free World INC (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Karolinska Institutet (1) · Medical University of South Carolina (1) · Philip Morris Products S.A. (1) · Prisma Health-Upstate (1) · Queen Mary University of London (1) · Roswell Park Cancer Institute (1)
United States (24) · Sweden (2) · United Kingdom (2) · Italy (1) · New Zealand (1) · Pakistan (1)
Peter Shields, MD (2) · Adam M Leventhal, PhD (1) · Amy J Arouni, MD (1) · Christelle Haziza, PhD (1) · Diann E Gaalema, PhD (1) · Elizabeth Oelsner, MD, MPH (1) · Haruka Minami, Ph.D. (1) · Hirofumi Tanaka, Phd (1) · Jenny A Bosson, MD, PhD (1) · Jin Ho Yoon, PhD (1) · Jonathan Austin, MD (1) · Madeeha Malik, PhD (1) · Markos Klonizakis, DPhil (1) · Martin Mahoney (1)
PMID 26459355, PMID 26941050, PMID 28376818, PMID 31515173, PMID 31531991, PMID 31773209, PMID 32896211, PMID 33857436, PMID 34128486, PMID 34611902, PMID 35363874, PMID 35971150, PMID 36593119, PMID 37230961, PMID 37548804, PMID 38873183, PMID 39142511, PMID 39868569, PMID 40239848, PMID 40394619, PMID 40533223
P30CA016056 (1), P50DA036105 (1), R01DA037446 (1), U01DA045530 (1), U54DA036114 (1)